Cholesterol Overload

My coronary arteries are a mess. I own lots of stents. I envy your low cholesterol. Do you #KnowFH? I do.

[Cholesterol Overload @HeartShapedWoes]

@CatDavisAhmed You’ll never be able to get through to everyone, but you’ve reached more people than you’ll ever possibly know. I’m grateful for all of that medical research and innovation, and I’m equally grateful for people like you.

[Cholesterol Overload @HeartShapedWoes]

@LaraLDLR @TheFHFoundation “No one in my family has to die from this anymore.” — so true! You are giving your little one the gift of a long and healthy life by testing early and treating long before it’s too late. ❤️👍

[Lara @LaraLDLR]

My brave boy!! His first blood draw to find out if he inherited FH from me. Finding out young because #FHCantWait No one in my family has to die from this anymore. #KnowFH @TheFHFoundation #Pediatrics #heartdisease #brave

[Cholesterol Overload @HeartShapedWoes]

@MakiAletha Brave and strong! It’s obvious that #HoFH isn’t going to slow her down.

[Joe @HeartAttackto5K]

#heartattacksurvivor https://t.co/gUwPwROfq9

[Cholesterol Overload @HeartShapedWoes]

@ethanjweiss My zen koan for the day: Prozac is Prozac except when it’s not.

[María J. Díaz Candamio @Vilavaite]

Opposite Day: Drug May Save Lives, So Drugmakers Offer To Cut Price

Praluent
not only reduced the risk of
#heartattack
#stroke
or #chestpain by 15%
but also appeared to ⬇️ risk of dying😲
@Forbes #ACC18 https://t.co/hY8a433Ryz

[ACC Media Center @ACCmediacenter]

“We need to reset our expectations” on small benefits for new drugs when added to already good treatments such as #statins, said #ACC18 Chair @JTKuvin on new Praluent results. @AP @MMarchioneAP https://t.co/8SlaDwZbIb

[Andrew Waxler @arwaxler]

ODYSSEY OUTCOMES shows alirocumab(Praluent) not only reduces adverse CV outcomes but also lowers all-cause mortality: a potential game-changer! Hopefully this will help with #PriorAuth in our high-risk patients @PaChapterACC @PAMEDSociety #ACC18 #PAdocs @Cardiology @CardioNews

[Thomas Dayspring @Drlipid]

Praluent succeeds in major trial; Will insurers pay? Valentin Fuster, who critiqued the trial at the meeting but was not involved in the study, said the data show that what is considered normal LDL-C today may be too high. https://t.co/jmzWt7iJvp @nationallipid

[Cholesterol Overload @HeartShapedWoes]

@AlastairMcA30 When I was growing up it was non-flat 7 UP soda and Saltines (non-Americans may have to look those up). That combo worked wonders. I’m sure it was just a mom-influenced placebo effect, but who cares? If a placebo effect helps you from puking your lungs out, good enough for me!

[Cholesterol Overload @HeartShapedWoes]

@CMichaelGibson This is a trick question. I want the medication that is most effective at lowering my cardiovascular risks, improving the quality of my life and extending my lifespan. Price may be a barrier to the most effective medicine, but how do I put a price tag on my own life?

[Sek Kathiresan MD @skathire]

New oral LDL-C lowering drug: bempedoic acid
New mechanism, possibly ATP citrate lyase inhibitor
~25% lower LDL-C
Outcomes trial 12K planned
? receive FDA approval based on LDL-C lowering

Due to cost PCSK9i, are we headed to statin + ezetimibe + bempedoic acid ahead of PCSK9i? https://t.co/9gSEYvKG2g

[Cholesterol Overload @HeartShapedWoes]

Feb. 28 was wheels-up day after five years in Hong Kong. My family has officially moved back to the U.S. Thanks to jet lag and a wide-awake 18-month-old, I got 10,000 steps in before 6 a.m. on my first night back in America. 🙂❤️ #KnowFH

[Cholesterol Overload @HeartShapedWoes]

@Toaster_Pastry I love it when exercise and commutes collide. 🙂👍❤️

[Cholesterol Overload @HeartShapedWoes]

@DrMarthaGulati @ThanassoulisMD @Drlipid Important point. Similar to how many drugs lower LDL (or raise HDL) but have shown little CV benefit. For LDL & CV benefits, statins work beyond doubt. Initial evidence suggests PCSK9i works. Other drugs: results mixed. I plan same caution for Lpa-lowering drugs. Await evidence.

[George Thanassoulis @ThanassoulisMD]

@HeartShapedWoes @Drlipid If your lp(a) is high:
1. Consider PCSK9i as they lower lp(a) as well as LDL (if not already on these)
2. Important for your family. FH is a serious disease but FH with high lp(a) appears to be worse.
3. You could be eligible for a Lp(a) lowering trial.

[Cholesterol Overload @HeartShapedWoes]

@Drlipid P.S.: I do plan to get my Lp(a) tested. I just don’t know what I’m supposed to do with the results.