https://t.co/Lqs1Xi1z2A
A paradigm shift in overall approach to Cystic Fibrosis, from biological & therapeutic POV. ENAC sodium influx - NLRP3 inflammasome priming in CF. Also CF shares many features with SAIDs, IL-1/IL-18/IL-1Ra signature, innate immune dysreg - periodic attacks
I am happy to share another publication from our group. Congratulations to @ScamblerThomas and @Heledd_6 for this outstanding finding. We are cracking the basic mechanism causing inflammation in cystic fibrosis.
@cftrust@LeedsCFSRC @cf_medicine
🗞️https://t.co/ONPSCwoxHm
Our latest paper demonstrating how ADAM10 shedding of the prion protein reduces amyloid-beta binding and toxicity is now available https://t.co/CKCgynUx58 😀 well done @Heledd_6 @DrNicki_c @h_a_rowland @ghowell2812@KateKellett1
Leeds SRC at the University of York attending the Yorkshire Immunology Group Symposium, @SamuelLaraR is presenting his work on the unfolded protein response in CF.