Bode Lab

Run by members of the Bode Lab. Doing all things related to natural products.

[Bode Lab @HelgeBode_Lab]

Happy to announce the first steps into NRPS/PKS engineering thanks to the work from Leonard and collaborations with the labs from Markus Kaiser and Michael Groll:
Bioengineering of syrbactin megasynthetases for immunoproteasome inhib... https://t.co/cW6McEJ4au

[Bode Lab @HelgeBode_Lab]

Leonard has applied the XUT NRPS engineering technology to solve the biosynthesis of the potent antibiotic odilorhabdin in collaboration with the Rolf Müller lab at @Helmholtz_HIPS. See his paper in @angew_chem: https://t.co/xurgMX9zr6

[Bode Lab @HelgeBode_Lab]

@mpi_marburg @HannahJeckel @IMPRS_Mic @knutdrescher Congratulations Hannah and Nadya! Well deserved!!!

[Bode Lab @HelgeBode_Lab]

CRISPR now also available for Xenorhabdus and Photorhabdus for easy access to natural products and manipulation of their biosynthesis: Please see the paper from Alexander in Microbial Cell factories: https://t.co/rt8ZKPpLGb

[Bode Lab @HelgeBode_Lab]

And here is another cool story about trans-AT PKS engineering in the same issue https://t.co/JdAOqTuDYK from the @piel_lab. Congratulations!!

[Bode Lab @HelgeBode_Lab]

Finally! After a long journey our latest NRPS engineering story is out at https://t.co/E77e2L7gn1 thanks to the hard work of several members from the @HelgeBode_lab

[Bode Lab @HelgeBode_Lab]

With our newest preprint on engineering NRPS we succeeded in optimizing our first-of-its-kind biocombinatorial technology. Read more here:

Guidelines for Optimizing Type S Non-Ribosomal Peptide Synthetases https://t.co/9lcuW9camI

[Bode Lab @HelgeBode_Lab]

The latest update for NRPS engineering, based on a evolutionary breakpoint within thiolation domains is out: https://t.co/WnNeC6imB0

[Papenfortlab @papenfortlab]

Next round in "the many things that regulatory RNAs can do" - this time: controlling natural-product synthesis. Fantastic collaboration with the Bode lab (@HelgeBode_Lab) published today in @NatureMicrobiol https://t.co/3gFliZ7b3T

[Bode Lab @HelgeBode_Lab]

An awesome addition to polyketide biosynthesis. TE disguises itself as KS
catalyzing branched polyketide formation. Read about Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide Gregatin A https://t.co/XFS5DMUlGZ

[Bode Lab @HelgeBode_Lab]

Luckily, despite severe jet lag, Helge’s given a clear, nice talk @SIMB_Microbio #NaturalProducts on NRPS engineering with a more efficient approach. Showing the advantages of artificial docking domains in splitting and reconstructing the megasynthetases

[Bode Lab @HelgeBode_Lab]

Finally... more than a module! Great NRPS work from the Schmeing lab: Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility https://t.co/WJkQuDaB7r

[Bode Lab @HelgeBode_Lab]

Who makes antibiotics and how do NRPS work? See the Grininger/Bode group performance for kids here: https://t.co/Z0edJU6OyU

[Bode Lab @HelgeBode_Lab]

🤔 could have submitted more

[J Org Chem/Org Lett @JOC_OL]

JOC invites you to take a look at this Note from first-time corresponding author Helge Bode & coworkers: (±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 https://t.co/OTj8m9bxqz

[Piel Lab @piel_lab]

We have new, hypermodified peptides for you! Check out our aeronamide (from Microvirgula) & polygeonamide (from deep-rock metagenome🤘🎸) story at @NatureChemistry https://t.co/OwFWyBRhMu #RiPPs

[Bode Lab @HelgeBode_Lab]

Natural products go RNA: The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation https://t.co/ORLrfqD8si

[Piel Lab @piel_lab]

Read Jörn‘s @nature #behindthepaper on how we developed the TransATor, a web tool for de novo structure predictions of trans-AT polyketides & why you need it https://t.co/LGaEsmP5ec

[Piel Lab @piel_lab]

The long-awaited TransAtor paper is out in @nchembio! TransAtor is a web application enabling de novo structural predictions of trans-AT PKS-derived polyketides. https://t.co/pmbV8MtOFG

[Bode Lab @HelgeBode_Lab]

First time to achieve peptide ligation in water, offering a chemical perspective of chicken-and-egg problem for the origin of life https://t.co/Or0oMjpnaI

[Bode Lab @HelgeBode_Lab]

Nice work by the Stanley-Wall lab: Pulcherrimin formation controls growth arrest of the Bacillus subtilis biofilm https://t.co/cWTUZvEc91