HighlanderLab

Research on managing and improving populations at @RoslinInstitute & @TheDickVet. Led by the chief Highlander @GregorGorjanc. Also on fediscience dot org

[HighlanderLab @HighlanderLab]

A free online course on "Breeding Programme Modelling with AlphaSimR" will launch this summer on @edXOnline!


Discover how breeding and genetics can contribute to #sustainable food production 🌽🥕🍎🐟🐮🐣🐝🐛


Register at https://t.co/mV0IZ7cyqH


Read the 🧵!


@wcgalp2022

[Gregor Gorjanc @GregorGorjanc]

New preprint: "Genomic models for accurate estimation of breeding values in Sitka spruce (Picea sitchensis Bong. Carr)" from the Sitka Spruced project https://t.co/lUa2WNjqYp

[Gregor Gorjanc @GregorGorjanc]

AlphaSimR course https://t.co/4vOmBP2HKl Week 3 opens with a discussion on genetic variation between relatives, with a focus on siblings. While mutation is the ultimate source of genetic variation (by introducing new alleles), recombination shuffles it through meiosis.

[Irene De Carlos @Ireneee_dc]

New preprint: “Modelling the impacts of imports of non-native honey bees into the native Apis mellifera mellifera population in Ireland”. We used stochastic simulations to study how non-native genes spread over time and affect fitness and honey production. https://t.co/ayXOoL4B9n

[Midlothian Science @MidlothScience]

Four professors from the Centre for Tropical Livestock Genetics and Health and the Roslin Institute will share their career and research journeys so far at an inaugural lecture showcase marking ten years of science at CTLGH.
Free and open to all. Please register ⬇️

[Gregor Gorjanc @GregorGorjanc]

Please share: Registration is now open for EUCARPIA Biometrics in Plant Breeding 2025 https://t.co/pcMg79ssjv

[Gregor Gorjanc @GregorGorjanc]

* Imprinting / gametic models on simulated and real beef data David Lopez Carbonell
* Selection for stability in plant breeding Dominic Waters
* Tracking inheritance of alleles within a dog pedigree Rosalind Craddock
* EUCARPIA Conference organisation https://t.co/D1Rnd0hAYg

[Gregor Gorjanc @GregorGorjanc]

I feel blessed & hyped after another fantastic HighlanderLab meeting covering:
* Selective breeding of artemia Bruna Santana
* Selection index (Smith-Hazel, desired gains, economic weights, …) @dantolly19

[HighlanderLab @HighlanderLab]

It can be tricky to visualise large #pedigrees. We have develped 'randPedPCA' for running #PCA on large pedigrees (can be >1M individuals). Check out our preprint https://t.co/k8qjR3q9GV and the R package https://t.co/5jgxkzYhem @GregorGorjanc @epigenci @hannes_becher

[Gregor Gorjanc @GregorGorjanc]

Lastly I gave a short course on Stochastic simulations of breeding programmes with AlphaSimR - a teaser for our free on-line course https://t.co/ca88zQ6VDf

[Gregor Gorjanc @GregorGorjanc]

@janaobsteter presented the work of Laura Strachan on Optimizing pedigree reconstruction and patriline determination in honeybees (with Jernej Bubnič and Janez Presern)

[Gregor Gorjanc @GregorGorjanc]

@Ireneee_dc presented her work on Modelling the Impact of Non-Native Honey Bee Importation on Native Apis mellifera mellifera Populations (with Laura Strachan, Grace McCormack, Jana Obšteter)

[Gregor Gorjanc @GregorGorjanc]

I presented the work of Letícia Lara on Evaluation of selective breeding programme designs for black soldier fly larvae body weight (with María Martínez Castillero, Thiago Oliveira, Ivan Pocrnić, Jana Obšteter)

[Gregor Gorjanc @GregorGorjanc]

Last week some of us attended the 1st @EAAPofficial Insect Genetics Workshop, which was organised with COST InsectIMP @CA22140 Action action by @beegirl_nz and @janaobsteter . We presented

[Gregor Gorjanc @GregorGorjanc]

In cross-validation for yield prediction, the ARG-based branch relationship matrix (BRM) demonstrated higher predictive ability than the standard site-based relationship matrix (SRM) when combining both subspecies.

[Gregor Gorjanc @GregorGorjanc]

GWAS hits with SRM (A) and BRM (B) were similar

[Gregor Gorjanc @GregorGorjanc]

(A) The standard site-based relationship matrix (SRM, VanRaden’s) and (B) the ARG-based branch relationship matrix (BRM) revealed similar population structure, with highly correlated (C) diagonal and (D) off-diagonal elements, though on different scales.

[Gregor Gorjanc @GregorGorjanc]

The age distributions for (A) nodes (ancestors), (B) mutations, and (C) SNP sites (i.e., first mutation at each site) were heavily right-skewed towards the present (as expected).

[Gregor Gorjanc @GregorGorjanc]

The ARG encoded genomic data more efficiently than the standard VCF: the tree sequence file for all chromosomes was 62 MB, compared to 228 MB for the VCF—nearly four times smaller!

[Gregor Gorjanc @GregorGorjanc]

Local trees from two genomic regions showed distinct patterns: (A) revealed deep separation between indica and japonica, linked to the DST gene associated with panicle length in japonica. The (B) region segregated in both subspecies and was linked to panicle traits in both.

[Gregor Gorjanc @GregorGorjanc]

After building the ARG, we demonstrated it captures biological signals using genealogical nearest neighbors (GNN) - it clearly distinguished indica and japonica rice subspecies and effectively represented population structure.