Houseley Lab

We study molecular mechanisms of genetic and epigenetic adaptation. @BabrahamInst, Cambridge, UK. Main funding @wellcometrust and @BBSRC. Views are our own.

[Houseley Lab @HouseleyLab]

We're winding down our Twitter account and moving to BlueSky

Find us at @houseleylab.bsky.social

We'll still post a few announcements here though...

[Houseley Lab @HouseleyLab]

Great work lead by Hanane Hadj-Moussa and Megan Ulusan

Babraham Institute @BabrahamInst

@BBSRC @UKRI_News

[Houseley Lab @HouseleyLab]

Is healthy ageing possible on a normal diet?

Our latest Preprint describes metabolic re-engineering of yeast to avoid senescence

The A2A mutant we created is super-fit late in life even on a rich high glucose diet

https://t.co/P15dgUtkq9

[Houseley Lab @HouseleyLab]

AMPK orchestrates responses to low nutrient availability from yeast to humans…

…including regulation of fatty acid synthesis through phosphorylation of the same enzyme

This conserved regulatory system presents an unexplored target for healthy ageing research across Eukaryotes

[Houseley Lab @HouseleyLab]

Congratulations to Hanane for her interview 🎉🎉

[Babraham Institute @BabrahamInst]

❄️ It has been chilly here recently, but what happens to animals that decide to freeze over the winter? Hanane, a Marie Curie Fellow in the Houseley lab spoke about this on Curious Cases (at 11:55)
Listen now: https://t.co/etJxDClXpt

[Houseley Lab @HouseleyLab]

Congratulations Hanane!

[British Society for Research on Ageing @BSRAgeing]

We're looking back on #BSRA2024 this week, and some of our amazing ECR members.

The Korenchevsky Prize was awarded to Hanane Hadj-Moussa from @HouseleyLab @BabrahamInst. BSRA's goals including supporting members careers to build capacity in the UK - https://t.co/HZtB56V6uD

[Houseley Lab @HouseleyLab]

@PaolaGarran @baptiste_piguet And last but not least: congratulations to Kieron for his talk on how defective DNA replication could drive drug resistance in lung cancer 🫁

And for winning the prize for the best 3rd year PhD students poster 🏆

We are proud of our lab's achievements this year 💪

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[Houseley Lab @HouseleyLab]

At @BabrahamInst, we recently held our annual Lab Talks, during which awesome science was discussed. In this #Thread, we are highlighting the accomplishments of our members this year🏆

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[Houseley Lab @HouseleyLab]

@PaolaGarran @baptiste_piguet Triple congratulations to @baptiste_piguet for his nomination at this year's Public Engagement Prize, for winning the prize of the best 1st year PhD students poster and for presenting his work at a 3-min flash talk 🥳🎉🏆

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[Houseley Lab @HouseleyLab]

@Xin_Ge_ @RoychoudhuriLab @DrTregoning @LintermanLab Congratulations Xin Ge

[Houseley Lab @HouseleyLab]

Join us at this year's BSRA meeting to discuss all things ageing!

We have some great speakers from academia and industry

Abstract deadline extended to June 14th

https://t.co/n8oXg7sLZi

[Houseley Lab @HouseleyLab]

Great work from @GabrielePicco2 @Garnettlab showing how WRN inhibitors can selectively target MSI cancer cells

[Garnett Lab @Garnettlab]

Our work 'Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells' is published today in @CD_AACR (https://t.co/gRWorXovlw). Using genetic tools, in 2019 @DepMapSanger and others reported WRN as a synthetic-lethal target in MSI cell line. 1/5

[Houseley Lab @HouseleyLab]

Looking forward to your comments 👩‍🔬 #ResearchMilestones #GeneticHeterogeneity #Transcription #PhDachievement

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[Houseley Lab @HouseleyLab]

🧪 We are proud to present our newest paper, entitled "Transcription as a source of genetic heterogenity in budding yeast" 🧬

Which is part of a series by @Yeast_Journal, named "Gene Transcription in Yeast" https://t.co/eacs2WIYFT

Read it at https://t.co/qbEUSSGXY9

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[Houseley Lab @HouseleyLab]

Finally, we propose that TRCs induce mutagenesis usually when replication is already perturbed, particularly during Break-Induced Replication, which would explain the role of transcription in gene copy number variation and the formation of extrachromosomal DNA circles.

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