Huichun Zhan, M.D.

Hematology physician and scientist, studying MPN neoplastic hematopoiesis and cardiovascular complications.

[Alex Rampotas @ARampotas]

1/ 🧵 So delighted to share our new paper, out today in Science Translational Medicine @ScienceTM. We built a CAR-T cell therapy that selectively depletes the disease-driving mutant calreticulin (mutCALR) cells in myelofibrosis — while sparing healthy blood stem cells👇

https://t.co/zfwYYSqT9h

[Dr. Anthony Letai @NCIDirector]

I’ve heard concerns about @theNCI funding in FY26—especially about the number of awards issued so far. Here’s some context. 🧵

[Hematopoiesis News @Hema_News]

.@sbudeptofmed's Dr. Huichun Zhan led this study identifying #megakaryocytes (MKs) as active immune regulators in myeloproliferative neoplasms, with JAK2V617F mutation and aging synergizing to reprogram MKs into inflammatory, immunemodulatory niche cells.

@Haematologica | https://t.co/orlBCYqE00

[Huichun Zhan, M.D. @HuichunZ]

Congratulations to all the Young Investigator Awardees @CAHON_hemonc

[BBC Breaking News @BBCBreaking]

Scientist James Watson, co-discoverer of the structure of DNA, dies aged 97 https://t.co/mKKkONkukL

[Huichun Zhan, M.D. @HuichunZ]

Mid-Autumn. Happy Moon Festival

[The Nobel Prize @NobelPrize]

Mary Brunkow and Fred Ramsdell – who have been awarded the 2025 Nobel Prize in Physiology or Medicine – gained decisive insights into how autoimmune diseases arise.

Brunkow and Ramsdell made a key discovery in 2001, when they presented the explanation for why a specific mouse strain (named scurfy) was particularly vulnerable to autoimmune diseases.

The medicine laureates had discovered that the mice have a mutation in a gene that they named Foxp3. They also showed that mutations in the human equivalent of this gene cause a serious autoimmune disease, IPEX.

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

[The Nobel Prize @NobelPrize]

This year’s medicine laureate Shimon Sakaguchi discovered a new class of T cells.

Sakaguchi was swimming against the tide in 1995, when he made a key discovery. At the time, many researchers were convinced that immune tolerance only developed due to potentially harmful immune cells being eliminated in the thymus, through a process called central tolerance.

Sakaguchi showed that the immune system is more complex and discovered a previously unknown class of immune cells, which protect the body from autoimmune diseases.

#NobelPrize

[Dana-Farber @DanaFarber]

Congratulations to @DrTonyLetai on being named the new director of @theNCI. An internationally renowned researcher and oncologist, Letai has helped shape our understanding of cancer through his study of cell death. His appointment is a testament to our continuing commitment to innovation and collaboration.

Learn more: https://t.co/0dkpwnamrh

[Zihai Li, MD, PhD @Zihai]

Tell me one contemporary biomedical scientist whose work has not been impacted by Dr. David Baltimore - such a towering figure in the field. RIP! https://t.co/unBS0KFrXf

[Tesla @Tesla]

Once you start letting FSD Supervised drive for you, doing a long-distance trip without it will feel like going back to the Dark Ages

[Martín E. De Simone @desimonemartin]

🚨 New working paper!

Can ChatGPT or generative AI transform education in low-resource settings? We ran a randomized controlled trial in Nigeria to find out.

The results? Powerful learning gains at a low cost.

👇

[𝗧𝗶𝗺𝗲𝗹𝗲𝘀𝘀 𝗠𝘂𝘀𝗶𝗰 ✨🎵 @Hoang_HQ]

How to play "Happy Birthday" Like Beethoven, Chopin, Brahms, Bach and Mozart Piano by Nicole Pesce

[Love Music @khnh80044]

Hungarian Dance No. 5 meets the timeless brilliance of Charlie Chaplin—moving flawlessly to the rhythm of the music. A true masterpiece of movement and melody! 😍✨

[Huichun Zhan, M.D. @HuichunZ]

Diminishing Objectivity in the Residency Application Process. JAMA. 2025;333(12):1034-1035. doi:10.1001/jama.2024.28397

[Wonder of Science @wonderofscience]

Testing teapots to see how well they pour. The best designs create laminar flow, minimizing drips and turbulence.

📽: zishahu2021

[European Hematology Association @EHA_Hematology]

At #EHA, we are thrilled to kick off the 2025 EHA-ASH Translational Research Training in Hematology (TRTH) spring Course! This immersive program brings together early-career researchers from around the world for a year-long journey of mentorship, collaboration, and skill-building in translational hematology research.

The TRTH workshop is designed to empower researchers with the tools they need to become a principal investigator in the field.

Wishing all participants an inspiring and productive start to the course!
Curious to learn more? Check out our TRTH-dedicated page: https://t.co/zzg0YhCCSI 

#TRTH2025 #HematologyResearch #TranslationalScience #ResearchTraining #EHA #ASH

[Robert Brodsky @DocsDock200]

Out in NEJM Evidence today. KEY TAKEAWAYS
•Of 42 people with severe SCD who had the procedure , 95% were alive at 2 yrs, and 88% are considered cured.
•Most people with SCD are eligible, which costs a fraction of the price of gene editing/therapy
#casgevy @ASH_hematology

[The Weather Channel @weatherchannel]

Punxsutawney Phil sees his shadow and predicts six more weeks of winter! #GroundhogDay

[The Figen @TheFigen_]

Skills from Football Managers