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The underlying cause of narcolepsy is the loss hypocretin-producing neurons in the hypothalamus. Although hypocretin levels are low in pt's w/ narcolepsy many therapies available do not target hypocretin production, if not hypocretin, then whats the target?
Let’s find out
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While the main problem in narcolepsy is decreased hypocretin, treatments mainly utilize stimulants or sedatives. It is important to remember how detrimental a lack of sleep can be to an individual, and thus proper treatment of narcolepsy is a crucial field of study.