Hunter Williams

Former @wakefb LB. Author. Hormone educator.
Peptides. Testosterone. Recovery. Performance.

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[Hunter Williams @HunterEsoteric]

Link to study here: https://t.co/mOH1Rq7Qlr

[Hunter Williams @HunterEsoteric]

The first randomized trial of resistance training on tirzepatide is here.

Researchers in Western Australia put 120 adults between 50 and 70 on tirzepatide for 40 weeks.

Half of them lifted weights three times a week, and the other half went about their normal lives. At the end, both groups had lost almost exactly the same amount of weight, roughly 22 kilograms each.

The group that lifted lost 25% less lean tissue.

Their strength went up 10 to 18%. The group that didn’t lift got 6 to 9% weaker over the same stretch.

To be fair, lifting reduced lean loss but didn’t eliminate it. The training was supervised, attendance was 91%, and most people won’t hit that on their own.

At the end of the day, Tirzepatide is a remarkable tool for taking fat off the body. However, a tool only does what it was built to do, and protecting your muscle was never its job.

That part falls on you!

Three days a week under a bar. Consider it part of the prescription.

[Hunter Williams @HunterEsoteric]

Your pituitary made about 2 IU of growth hormone a day at 25. By 60 you are down to roughly a quarter of that.

Peptides push the system for a while. Eventually all roads lead to HGH.

My full masterclass. Free.

00:00 Why this one took so long
03:07 What HGH actually is
05:58 Hormones, peptides, and proteins
09:58 The GH system explained
12:07 Why IGF-1 is what matters, not GH
14:11 Why it declines with age
18:13 Who it is actually for
25:07 Dosing and the IU ladder
29:02 Why the low end wins
38:03 Do you need to cycle it
42:32 Sequencing with the GH peptides
47:18 Mixing and injection
50:07 What to track
53:07 Stacking with testosterone and GLP-1s
57:10 Troubleshooting
1:01:01 The questions I get most
1:06:19 Where the field is heading
1:07:44 My verdict

[Hunter Williams @HunterEsoteric]

If you're in perimenopause and trying to figure out where a GLP fits, ask me here.
https://t.co/TtpUvyyfwb

[Hunter Williams @HunterEsoteric]

Perimenopausal women are getting put on GLPs before anyone checks their hormones.

Then it "doesn't work." Or they drop 10 pounds in two weeks and can't walk up the stairs.

The GLP usually isn't the problem. The body isn't ready for it.

Get the hormones checked first. Get the blood work in a better place. A lot of the time the weight starts coming off before a GLP ever enters the picture.

When it does make sense, newest isn't always best. Everyone wants reta. Tirzepatide is often the better place to start, and you can always move up.

Half a pound to a pound a week is a great pace. It feels slow. Do the math over a year.

And a GLP doesn't replace the work. It raises the stakes on it. Lift heavy. Eat enough protein. Stop starving yourself and then wondering why it stopped working.

Stephanie Gambetta breaks it all down here.

[Hunter Williams @HunterEsoteric]

If you've got questions about peptides, come ask me here
https://t.co/TtpUvyxHGD

[Hunter Williams @HunterEsoteric]

Are COA's a cottage industry to give people warm, fuzzy feelings?

The vial that got tested isn't the vial you're injecting.

I get why they exist. I think they're probably even necessary. They're just way overemphasized.

Here's what I actually trust instead.

[Hunter Williams @HunterEsoteric]

If you want to dig into your own GLP questions with me, come hang out here
https://t.co/TtpUvyxHGD

[Hunter Williams @HunterEsoteric]

A lot of people blame glucagon for the heart rate bump on reta.

That's definitely true.... BUT, Mazdutide hits glucagon too, but the numbers I've seen look a lot closer to tirzepatide.

Taylor and I have been testing it. Here's what we're finding, and who it might actually be for.

[Hunter Williams @HunterEsoteric]

If you're deciding between Reta, tirzepatide or getting your hormones sorted first, ask me here.
https://t.co/TtpUvyxHGD

[Hunter Williams @HunterEsoteric]

I was wrong about retatrutide.

I used to think it beat tirzepatide in almost every case.

It's still the king of fat loss. But I'm now seeing people do worse on it, especially women in their 40s and 50s.

Here's who it backfires on.

[Hunter Williams @HunterEsoteric]

Saturday Morning Coffee Talk 10/17/26 https://t.co/wVQ77sPhvb

[Hunter Williams @HunterEsoteric]

Saturday Morning Coffee Talk 10/3/26 https://t.co/kKmicIxuPY

[Hunter Williams @HunterEsoteric]

Saturday Morning Coffee Talk 9/5/26 https://t.co/ObZZAEBeaZ

[Hunter Williams @HunterEsoteric]

Saturday Morning Coffee Talk 8/22/26 https://t.co/PebXt88WcF

[Hunter Williams @HunterEsoteric]

Most people think DSIP is just a sleep peptide.

A 2003 study showed it cut tumor incidence 2.6 fold and extended maximum lifespan by 24% in mice.

Full episode on 20+ peptides and cancer here 👇
https://t.co/bT1bG68Bam

[Hunter Williams @HunterEsoteric]

Saturday Morning Coffee Talk 8/8/26 https://t.co/SlDHIueYlm

[Hunter Williams @HunterEsoteric]

Also available on 👇

YouTube: https://t.co/z7vIOxgeR8

Spotify: https://t.co/u2XKyVLNrL

Apple: https://t.co/SpjsyBCstH

[Hunter Williams @HunterEsoteric]

Most people take DSIP expecting a peptide version of Ambien. That is why they write it off.

My full masterclass on it. Free.

00:00 Why DSIP gets misused
03:26 What DSIP is and is not
06:38 Sleep architecture and the stress axis
08:24 How DSIP actually works
10:58 Who it helps and who should skip it
14:20 The three dosing tiers
22:06 Pairing with Epitalon
25:38 Stacks that work and what to avoid
34:30 My verdict on DSIP

[Hunter Williams @HunterEsoteric]

Saturday Morning Coffee Talk 7/25/26 https://t.co/1Yequ3EGv0