Institute of Innate Immunity

Excited about innate immune receptors, signaling and functions in health and disease

[Dagmar Wachten & lab @DagmarWachten]

Thrilled to announce that our #SFB1454 got funding @UniBonn @IIIBonn #Metaflammation

[Dagmar Wachten & lab @DagmarWachten]

Come and visit our exhibition! This is a great project jointly coordinated by the #SFB1454 #MuseumKoenig #UnistiftungBonn @UniBonn @ImmunoSens @IIIBonn

[Institute of Innate Immunity @IIIBonn]

Excellent short video from @IIIBonn and @bernardo647 postdoc Ibrahim on his recently published paper!

Thanks to @ImmunoSens for the production!

Manuscript link here: https://t.co/BKEjV7Dibw

[ImmunoSensation @ImmunoSens]

🎬 Episode 10 of #SpotOnScience is out!

👨‍🔬 This time, Ibrahim Hawwari (@IIIBonn @UniklinikBonn @UniBonn) introduces his work revealing that platelets modulate the immune response of human monocytes.

#Immunology #Research

https://t.co/axhxj0jrGN

[Dagmar Wachten & lab @DagmarWachten]

Preprint from our #optogenetics team: novel photoswitch that allows an up to 400-fold induction of target gene expression by blue light! Perfectly suited to express biotherapeutics! Great collaboration @IIIBonn @MoeglichLab #ningaloobiosystems https://t.co/KdURxaWnUB

[Dagmar Wachten & lab @DagmarWachten]

Teaching the next generation of scientists all about what we do in the lab #TürenaufmitderMaus – big thank you to my whole lab and, in particular, Fabian @IIIBonn @for5547 #sfb1454 @ImmunoSens

[FISchmidtLab @FISchmidtLab]

Ever wondered why there is so little #microscopy of #GSDMD pores? Check out how Lisa Schiffelers used #Nanobodies to stabilize monomeric GSDMD in the plasma membrane, to dissect the steps of pore formation, and to develop some new ideas for therapy.
https://t.co/DmCnqN8Chl

[ImmunoSensation @ImmunoSens]

Dear Cluster members and associated scientists,

the abstract submission for the Cluster Science Days 2024 is open! Please submit your abstract by September 26th. We are thrilled to feature your interesting research and can't wait to offer you an exciting program.

[Radek Nowak @RPNowak]

We are hiring! Looking for a #postdoc to join the team in the Nowak Lab to focus on chemical biology in cells and recombinant systems. Excited about protein degradation, small molecule proximity? get in touch!
#TPD #InducedProximity #ChemicalBiology
https://t.co/SYxOT8RwCi

[ImmunoSensation @ImmunoSens]

🚨 Open position. The group of Eva Kiermaier at the LIMES Institute at the University Bonn ist offering a

PhD position in Cellular Immunology!

You can apply until October 15th.

[ImmunoSensation @ImmunoSens]

Join the Flow Cytometry Day 2024! The Flow Cytometry Core Facility at the UKB hosts an all-day theoretical course on flow cytometry September 3rd at the BMZI at the UKB. Beginners and advanced students are welcome to join the lectures.

Register here: https://t.co/aJjAZvGoLv

[EMBO Mol. Medicine @EmboMolMed]

Our August issue is online !
The cover highlights the article by I. Hawwari, L. Rossnagel, B. Franklin et al. & illustrates a novel intercellular communication mechanism between #platelets & #monocytes 👉https://t.co/t7Wb6nC1NX

Scientific illustration by Salie Maasewerd @IIIBonn

[Jonathan Schmid-Burgk @schmidburgk]

1/8 How can we enrich cells with a defined transcriptional state, but without killing them? Please read on!
https://t.co/PggrPRg75L

[Nature Metabolism @NatMetabolism]

RESEARCH | @DagmarWachten @Kornfeld_JanW et al. (@IIIBonn, @NATSDU):

Truncated version of adenylyl cyclase 3 acts as a cold-induced rheostat during long-term brown #adipose tissue activation 🥶

https://t.co/Io24OPsK7w

[Institute of Innate Immunity @IIIBonn]

Congrats to @bernardo647 and all authors!! 🎉💫
Very happy to see this out!
Excellent summary thread below ⬇️

[Institute of Innate Immunity @IIIBonn]

Congrats to @DagmarWachten and all collaborators on your new paper in @NatMetabolism

[Dagmar Wachten & lab @DagmarWachten]

Thrilled that our huge team effort with @Kornfeld_JanW is out in @NatMetabolism 🥳 supported by @TRR_BATenergy A huge thank you to all collaborators! If you want to know how a truncated AC3 isoform regulates #BAT function, have a look here https://t.co/sOZAersi2D

[Institute of Innate Immunity @IIIBonn]

Matt made it onto the CSHL board! He'll present his most recent work later this morning #cshlimmune

Link to his preprint below!

[Institute of Innate Immunity @IIIBonn]

@biorxivpreprint #2 from Matt newly identifies increased cytosolic sodium as a common activator of the #NLRP3 inflammasome in human macrophages.

Endo/lysosomal damage results in Na+ driven cell swelling which causes K+ efflux, and inhibits trafficking

https://t.co/GX3NevPogS

[Institute of Innate Immunity @IIIBonn]

Finally, Prof. Eicke Latz will present brand new data on NLRP3 and NLRP1 signalling on Thursday afternoon!

Good luck to all the attendees and have a great meeting!

[Institute of Innate Immunity @IIIBonn]

The @IIIBonn is being represented this week @TOLLconference #TOLL2024

P-189 Theresa Wagner: Sphingomyelin d18:1/14:0 as Endogenous Ligand of Toll-Like Receptor 4

P-182 @Roisin_McManus_ : SPHINGOMYELIN 14:0 – A DRIVER OF NEUROINFLAMMATION DURING OBESITY

1/n

[Institute of Innate Immunity @IIIBonn]

P-054 Marta Lovotti: PALMITOYLATION INFLUENCES NLRP3 SIGNALING

P-018 Jen Würth: THE NLRP1 INFLAMMASOME – A NOVEL PLAYER IN THE PHLEBOVIRUS-HOST ARMS RACE

2/n

[Dr Róisín McManus @Roisin_McManus_]

Excited to share our review on NLRP3 #inflammasome signalling in #Alzheimer’s disease with @eickelatz. Check it out to learn the latest on NLRP3 activation, the inhibitors in #clinical trials and new NLRP3-targeted therapies under development

https://t.co/sdj0TWifRD