This evidence-based guide breaks down the Surviving Sepsis 2026 bundle: from fluids and vasopressors in the first hours to antibiotics, source control, and adjunctive thresholds every clinician needs to know.
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Delighted to present our clinical case report at the National Kidney Foundation Spring Clinical Meeting 2026! Inspired by the ground breaking research transforming kidney care!
#NKFSCM2026@nkf
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Today, I presented a case of pyogenic liver abscess with transdiaphragmatic extension and concurrent lung abscess due to Streptococcus intermedius. Was nervous but excited to talk through such a cool case!
🏠 Take-home:
1. Echo gives a PASP estimate, not a diagnosis
2. Use ESC probability (Low/Intermediate/High)
3. Normal echo does NOT rule out PH if suspicion is high
4. RHC is required to confirm dx, measure PVR, and classify hemodynamic profile
🫁 Your patient has dyspnea on exertion. The echo report says "PASP 52 mmHg - consider pulmonary hypertension."
But does that mean they have PH?
Not necessarily. Here's what echo can (and cannot) tell you. 🧵 #MedEd#Cardiology#Pulmonary
PH is classified into 5 WHO Groups:
1️⃣ PAH (idiopathic, CTD, drugs)
2️⃣ Left heart disease ← common
3️⃣ Chronic lung disease/hypoxia
4️⃣ CTEPH
5️⃣ Multifactorial
Why does this matter? Because Group 2 & 3 do NOT get PAH therapy. Getting the group right changes everything
So, what do you do with an abnormal echo?
Clinical suspicion → 🔬 TTE → Low prob: look for alternatives → Intermediate/High: V/Q scan → ➡️ Right Heart Catheterization
Echo probability guides who goes to cath - not whether PH exists.
The overdiagnosis problem is real.
When borderline elevation on echo is compared to invasive mPAP?
~50% correlation.
High PASP on echo alone ≠ PH diagnosis. It's an indication to look further - not a diagnosis to hang your hat on.
Fisher MR https://t.co/zwZcEdlglK PMID 19164700
However, Echo lies. Here are some of the ways how:
❌ No TR jet in ~30% of patients → can't calculate PASP (absence ≠ no PH)
❌ IVC-based RAP overestimates by up to 10–15 mmHg
❌ Non-parallel Doppler beam → underestimates TRV
❌ PASP ≠ mPAP - they diverge as PVR rises
The 2022 ESC/ERS Guidelines moved away from a single TRV cutoff.
Now we use echo probability categories (TRV + signs):
✅ TRV ≤2.8 + no signs → Low
🟡 TRV ≤2.8 + signs OR 2.9–3.4 → Intermediate
🔴 TRV ≥3.4 → High
"Signs" = RV dilation, D-septum, TAPSE <17mm, PA dilation