Running a lab at Kyushu University, studying how membrane abnormalities are linked to diseases. 九州大学医学部で、細胞膜の異常と疾患との関わりを研究する研究室を主宰しています。大学院生を募集中です。研究室見学も歓迎します。
Our work has been published in PNAS.
We identified a previously unrecognized membrane structure formed at the base of expanding blebs, which we named the “sub-bleb invagination (SBI).”
https://t.co/us4Fk9xU1B
We coined this mechanism CODE (CaMKII-based Osmotically-driven Deformation).
This work was spearheaded by Yuki Fujii, a 3rd-year PhD student,
and highlights CaMKII as a physical scaffold modulating cytoplasmic properties during blebbing.
We’re excited to share that our paper
“CaMKII nucleates an osmotic protein supercomplex to induce cellular bleb expansion”
has been published today in The EMBO Journal!
🔗 https://t.co/6kHkU3ySAJ
These CaMKII-based assemblies are excluded from actin meshwork and accumulate inside blebs,
creating a local protein concentration gradient.
With Dr. Yuji Sakai (Yokohama City University),
we show this gradient produces enough osmotic pressure to drive bleb expansion.
本日、私たちの論文
「CaMKII nucleates an osmotic protein supercomplex to induce cellular bleb expansion」
が The EMBO Journal に出版されました。
🔗 https://t.co/6kHkU3ySAJ
細胞の運動に関わるブレブを、「CaMKIIの発揮する浸透圧」の観点から捉え直した研究です。
A new paper demonstrating that EMT-associated changes in lipid metabolism contribute to chemotherapy resistance in cancer cells has now been officially published as the Version of Record in eLife. https://t.co/o7ksUYVa5j
上皮間葉転換(EMT)に伴う脂質代謝の変化が、がん細胞の化学療法抵抗性に関与することを示した論文が、eLife に Version of Record として出版されました。本研究は、当研究室の松本助教と愛知医科大学の猪子先生を中心に多くの共同研究者との連携によって実現した成果です。https://t.co/o7ksUYVa5j
Led by Dr. Kenji Matsuzawa (Kyushu Univ.) and Assoc. Prof. Makoto Suzuki (Hiroshima Univ.), we identified a novel molecular mechanism by which epithelial cells sense tensile forces from neighboring cells, and revealed its role in neural tube closure.
https://t.co/EFLE4utfvS