INDUCTION trial

[INDUCTION trial @InductionTrial]

Hey, INDUCTION Trial is about to start!
This is a Phase III study evaluating efficacy and safety of a single-dose regimen of liposomal amphoteticin B as induction therapy of disseminated histoplasmosis in aids
#ambisome #histoplasmosis #aids
#ClinicalTrials #mycoses

[INDUCTION trial @InductionTrial]

🦠 A histoplasmose é mais comum nas regiões Norte, Nordeste, Centro-Oeste e parte do Sudeste do 🇧🇷.
O fungo Histoplasma capsulatum vive no solo e pode afetar gravemente pessoas imunossuprimidas.
🌍 Informação e vigilância salvam vidas!
#Histoplasmose #SaúdePública

[INDUCTION trial @InductionTrial]

No Induction Trial, usamos o DOOR (Desirability of Outcome Ranking) para avaliar os desfechos de forma ampla: cura, efeitos adversos, reinternações e mais.
Um olhar centrado no paciente para doenças negligenciadas.
Inovação brasileira! 🇧🇷🔬
#InductionTrial #Histoplasmose #DOOR

[INDUCTION trial @InductionTrial]

📍 Em 18/08, o Dr. Alessandro Pasqualotto apresentou na Duke University os avanços do Induction Trial sobre histoplasmose em pessoas com HIV/AIDS. Mais de 150 pacientes já incluídos. Ciência brasileira ganhando destaque internacional!
#Histoplasmose #HIV #InductionTrial

[INDUCTION trial @InductionTrial]

O maior estudo clínico sobre histoplasmose está em curso no Brasil! O INDUCTION TRIAL já incluiu 155 pacientes e avalia a eficácia de uma dose única de anfotericina B em pessoas com AIDS.
🚨 Impacto direto no SUS e nas diretrizes da OMS!
#HIV #SUS #Histoplasmose

[INDUCTION trial @InductionTrial]

Histoplasma PCR is useful to monitor patients receiving induction therapy.
Better performance than Histoplasma Antigen testing.
@a_alanio @AudeSturny

https://t.co/0HzZS2pIWk

[INDUCTION trial @InductionTrial]

Evaluation on implementation of Histoplasma antigen testing as a package of care in advanced HIV disease - a qualitative study

https://t.co/yTM8zbLeOE

[Sociedade Brasileira de Infectologia @SBInfectologia]

A SBI e a SGI lançaram o Guia de manejo de infecções relacionadas a desastres climáticos como parte das ações da Força-tarefa em prol do Rio Grande do Sul.

Acesse o Repositório de Emergência do Rio Grande do Sul no site da SBI (https://t.co/eUslWOmoSv) e faça o download.

[INDUCTION trial @InductionTrial]

@modernHealthMe Disseminated histo

[INDUCTION trial @InductionTrial]

DOOR scale will be used as a secondary endpoint, as follows:
(i) Death within the first 2 weeks
(ii) Death within 10 weeks
(iii) Grade 4 lab abnormalities in the first 2 weeks
(iv) Grade 3 lab abnormality in the first 2 weeks
(v) Survival at week 10

[INDUCTION trial @InductionTrial]

Patients will be randomized to two study arms: single high dose of L-AmB (10 mg/kg) vs. standard of care (3 mg/kg for 2 weeks).

Estimated sample size is 279 patients.

Overall survival at week 2 will be the primary endpoint for the study.

[INDUCTION trial @InductionTrial]

A single high dose (10 mg/kg) of liposomal amphotericin works pretty well as induction therapy for cryptococcal meningoencephalitis.
Why wouldn’t be the case for histoplasmosis? A phase II trial was recently published with exciting results in CID.
#histoplasmosis #AIDS

[INDUCTION trial @InductionTrial]

Picture taken during kick off meeting for the Indiction Trial in Porto Alegre, South of Brazil (March 23, 2024)

[INDUCTION trial @InductionTrial]

https://t.co/uJexNGQiFC NCT05814432