I'm thrilled to share this literature review with you all regarding Post Inflammatory Polyps (PIPs) and Colorectal Cancer in Inflammatory Bowel Disease.
@PeterLakatos, @TBessissow , @panuwetwittayakhlang, @mcgillu, @cusm_muhc
doi: https://t.co/al6VUOY1oD
Twelve principles to guide therapy in Crohn's disease
1/ Crohn's disease is progressive
With long-term, irreversible bowel damage, disability and poor quality of life the result.
- -
2/ Diagnostic delay is associated with worse outcomes
Ensure effective systems are in place to mitigate against this.
- -
3/ Disease complications can be prevented with effective therapy
This may involve over-treating a few patients to avoid under-treatment the majority.
- -
4/ Starting effective therapy early results in the best outcomes
Effective therapy means an advanced therapy - anti-TNF or anti-IL12/IL23 or anti-integrin or JAKi
- -
5/ There is a disconnect between symptoms and inflammation
Use non-invasive monitoring tools like faecal calprotectin and intestinal ultrasound
- -
6/ Biosimilar anti-TNFs are the most cost effective drugs; they work, are accessible, and allow for rapid dose escalation
This might be infliximab plus azathioprine or adalimumab (+/- AZA) and next year also ustekinumab
- -
7/ Early ileo-caecal resection for offers excellent long-term outcomes for many
This should be offered to all newly diagnosed patients with limited terminal ileal disease.
- -
8/ 5-ASA compounds do not work effectively in Crohn's disease
They only work at the mucosal level and Crohn's is a transmural disease.
- -
9/ Steroids do not heal the mucosa in Crohn's disease
Do not (over)use them.
10/ Dietary therapy is important in Crohn's disease
Use exclusive enteral nutrition in place of steroids for small bowel disease. It works in adults as well as kids. Use low residue diet for stricturing disease, and Mediterranean for everyone else.
- -
11/ The psychological harm associated with Crohn's disease is high
It starts early in the disease course and includes suicidal ideation and completed suicide. Do not underestimate this.
- -
12/ Use a multi-disciplinary team
IBD specialist nurses, dietary support, smoking cessation, psychological support, effective monitoring, radiologists, pathologists, surgical involvement, and a holistic approach.
It was truly an honour and pleasure hosting @IvannaCandel 🇦🇷 and Kang Chao 🇨🇳 for a clinical observership in our IBD unit during the summer @UZLeuven@KU_Leuven! Grateful to #ECCO and #AOCC for their support in making these fellowships possible !! #unitedwestand#globalIBD🌎
Un poco de lo qué pasó en el segundo día del IBD Update 2023.
Muchas gracias @mariamaguas por tu profesionalismo y dedicación.
#janssen#Telemedicine#IBD