Iwase Laboratory

Official account of the Iwase Lab research group @umich. We study chromatin dynamics in the brain & rare disease.

PI @brainchromatin

[Iwase Laboratory @Iwase_Lab]

In honor of the @KARESFoundation 5K race this weekend, we're highlighting #KDM5C all week. Over the next 5️⃣ days we'll share a 🧬 fun fact, 🥳 major milestone, or 🤓 research review about one of our favorite genes. Stay tuned! Follow #KARES5K & this thread for all the details ⬇️

[Iwase Laboratory @Iwase_Lab]

Thanks for following along as we shone a spotlight on the #KDM5C gene in support of the 2025 @KaresFoundation #KDM5C5K race 👟🏃‍♀️👩‍🦽🤸‍♂️

If you missed any fun facts, major milestones, or research reviews take a peek at the thread below to catch up! 👇🤓

[Iwase Laboratory @Iwase_Lab]

In honor of the @KARESFoundation 5K race this weekend, we're highlighting #KDM5C all week. Over the next 5️⃣ days we'll share a 🧬 fun fact, 🥳 major milestone, or 🤓 research review about one of our favorite genes. Stay tuned! Follow #KARES5K & this thread for all the details ⬇️

[Iwase Laboratory @Iwase_Lab]

@KaresFoundation Tomorrow @KARESFoundation #KARES5K race weekend begins!

🧬 Fun fact! Did you know #KDM5C is one gene in a family of genes? Why do so many genes have similar jobs? What are their roles in brain development & function? Read more about why we study this https://t.co/uHgj04ntfn

[Iwase Laboratory @Iwase_Lab]

In honor of the @KARESFoundation 5K race this weekend, we're highlighting #KDM5C all week. Over the next 5️⃣ days we'll share a 🧬 fun fact, 🥳 major milestone, or 🤓 research review about one of our favorite genes. Stay tuned! Follow #KARES5K & this thread for all the details ⬇️

[Iwase Laboratory @Iwase_Lab]

@KaresFoundation We’re proud to support the @KARESFoundation #KARES5K race.

Today we share another #KDM5C research review 🤓 Human research is key to understanding the broad phenotypes in the human population. 2 KDM5C-specific human studies are underway. Learn more https://t.co/EdjE7VxvFl

[Iwase Laboratory @Iwase_Lab]

📢ATTN #KDM5C researchers!
🧬Funding opportunity from @KaresFoundation to support KDM5C research
📅 LOI due 9/30
⬇️ Details!

[National Organization for Rare Disorders (NORD) @RareDiseases]

The @KaresFoundation is offering grants up to $40K to support research on #KDM5C genetic variants. Submit a 1–2 page Letter of Intent (LOI) to [email protected] by Sept 30.

LOI should include:
- Scientific aims
- Rough timeline
- Rough budget
- Direct impact on KDM5C community

Select applicants will be invited to submit full proposals due Nov 2025. Questions? ➡️[email protected]
https://t.co/JFX1O5FXDH
#ResearchGrant #Genetics

[Iwase Laboratory @Iwase_Lab]

This paper was lead by former postdoc (now professor!) Dr. Takao Tsukahara. Special thanks to our colleagues in the Iwase and Sutton labs. Read it in @CellReports https://t.co/5Zru0vKNnj

[Iwase Laboratory @Iwase_Lab]

Why are there 6️⃣ writer & 6️⃣ eraser enzymes for H3K4me in mammals? We identify an instructive role for H3K4me in controlling 🧠 synapse function & a division of labor among the KMT2 writers in regulating homeostatic synaptic scaling.

[Iwase Laboratory @Iwase_Lab]

This research was lead by former MD-PhD student Dr. Robert Porter, with contributions from Iwase lab mates and wonderful collaborators. Read it in @CellReports https://t.co/BVOalNWjrR

[Iwase Laboratory @Iwase_Lab]

Earlier this year we uncovered 🧠 neuron-specific splicing events for 14 chromatin regulators 🧬 including H3K4 demethylase #LSD1 and reader #PHF21A. Alternative splicing of ubiquitously-expressed chromatin regulators, therefore, can exert neuron-specific function.

[Iwase Laboratory @Iwase_Lab]

We are proud to support the @KaresFoundation and #KDM5C 5k race!

[Kares Foundation @KaresFoundation]

📌 Our 5K funds help make real impact—both in the lab and in life.

Your generosity helps provide:
✨ Travel stipends for families
🎉 A special community outing
🤝 Meaningful connections between families and scientists, and more!

Give today: https://t.co/sKQmb8Tl4z

[Iwase Laboratory @Iwase_Lab]

Work lead by former postdoc Dr. Masayoshi Nagai with great contributions from Iwase lab mates and collaborators. https://t.co/P97YlF0ecQ

[Iwase Laboratory @Iwase_Lab]

#PHF21A is in the spotlight! Last year we published that neuronal PHF21A isoform expression precedes neuronal LSD1 expression during human neuron differentiation & mouse brain development. Mouse models show Phf21a neuronal splicing prevents excess synapse formation.

[Bing Ye @byneuron]

Tenure-track assistant professor position in neuroscience or physiology at University of Michigan LSA Molecular, Cellular, and Developmental Biology (MCDB) https://t.co/T6zxidYd9p

[Iwase Laboratory @Iwase_Lab]

@MicheleLabUM @CellReports @UMPhysiology Thanks for sharing our work, Dan!

[Iwase Laboratory @Iwase_Lab]

@KaresFoundation We are excited to meet the families & researchers that can make it to the #KDM5C @KARESFoundation Family & Science Conference in Ann Arbor, MI June 26-28, 2026. Learn more at https://t.co/8gIHhoTMfz

[Iwase Laboratory @Iwase_Lab]

In June PhD candidate Ilakkiya presented at the @KaresFoundation #KDM5C Awareness Day event. She shared the mission of our lab and her work on #KDM5C in a heartfelt and impactful talk. Ilakkiya says, "I'm grateful to be serving this community!"

[Iwase Laboratory @Iwase_Lab]

This work was lead by PhD candidate Cecilia Gavilan, with contributions from multiple Iwase lab members. Check it out online! https://t.co/KDSOKRFYtM

[Iwase Laboratory @Iwase_Lab]

New paper alert! 📣 A #PHF21A variant reduces splicing efficiency of PHF21A isoforms while maintaining DNA binding capability. Reduced dosage rather than impaired DNA binding likely contributes to the cognitive impairments seen in the individual with this variant.