Journal of Cell Biology

The Journal of Cell Biology (JCB) publishes peer-reviewed research on all aspects of cellular structure and function. Est. 1955 - @RockUPress

[Journal of Cell Biology @JCellBiol]

Li Liu and David E. Levin demonstrate that heat shock activates the #yeast high-osmolarity glycerol pathway SAPK Hog1 and the cell wall integrity pathway SAPK Mpk1 sequentially through the formation of a novel protein complex. https://t.co/9WTbFLJLWo

[Journal of Cell Biology @JCellBiol]

.@yasuhhirano17, @tatsuofukagawa1 @UOsaka_en and colleagues reveal the molecular organization of functional #kinetochores in living cells via FCS-calibrated molecular counting. https://t.co/q8hpLe1trL

#CellCycle #CellDivision #Biophysics

[Journal of Cell Biology @JCellBiol]

Auditory and balance information is transmitted from hair cells to the brain by statoacustic sensory neurons. Rumbo, Bañón et al. identifed the chemokine cxcl14 as a novel guidance cue for inner ear pioneer axons, relevant for circuitry establisment. https://t.co/DbVI1amS38

[Journal of Cell Biology @JCellBiol]

Weronika E. Stachera, Jeffrey B. Woodruff et al. reveal that the E3 ligase TRIM37 recognizes a C-terminal domain, called IDR+ASH8, on the #centrosome scaffold protein Cep192. The IDR+ASH8 motif is sufficient to transform EB1 and GFP into TRIM37 substrates. https://t.co/E9C9tilvX6

[Journal of Cell Biology @JCellBiol]

Developmental elimination of electrical synapses by UNC-51/UNC-76–mediated vesicular transport. New study from Hao Huang, Yuzhi Yang, Lingfeng Meng and collegaues (Zhejiang University-University of Edinburgh Institute) https://t.co/LIVkX0vvWJ

#Development #CellSignaling

[Journal of Cell Biology @JCellBiol]

Bayazid, Bock et al. show that Rac1 deletion in mice causes postnatal cystic dysplasia resembling human multicystic dysplastic kidney disease. Rac1 organizes #actin to enable primary #cilia formation & tubular maturation in response to mechanical stress https://t.co/mLNnNqfFMP

[Journal of Cell Biology @JCellBiol]

Explore recent #Tools papers published in JCB. These papers describe new methods for segmentation & quantitation of electron #microscopy data, expansion microscopy that reveals interactions between #organelles, & in vivo mapping of #peroxisome dynamics 👉 https://t.co/6GFTGXpTIA

[Journal of Cell Biology @JCellBiol]

Alström syndrome is a #cilia-related disorder caused by loss of ALMS1, a proximal #centriole protein. Phan, Reiter et al. show that ALMS1 protects centriole integrity to enable #centrosome-directed trafficking during cilia formation and maintenance. https://t.co/4AGedoGuY9

[Journal of Cell Biology @JCellBiol]

Dubenko et al. show that securin stabilized in response to #DNADamage signaling excessively accumulates during longer G2/M arrests. Upon commitment to #mitosis, completion of securin degradation is delayed, causing aberrant divisions and cell death https://t.co/bm1od4Efs3

[Journal of Cell Biology @JCellBiol]

Our November issue is here! https://t.co/CBDvFj2bnK
🔬 The cover shows a live L4-stage #Celegans showing the small GTPase RAL-1 (red), the elaborate dendritic arbor of PVD mechanosensory neurons (green), and epithelial nuclei (blue). From Wu and Reiner: https://t.co/TyhXD2PRFO

[Journal of Cell Biology @JCellBiol]

Chi Zhang, Jorge D. Calderin, Rutilio A. Fratti et al. @MCB_Illinois show that Saccharomyces cerevisiae produces PI(3,4,5)P3 via Vps34 activity on vacuoles to regulate homotypic fusion. https://t.co/n97LX3q88t

#Biochemistry #Membrane #lipid #Organelles #BuddingYeast

[Journal of Cell Biology @JCellBiol]

Taylor and Cabernard @UW describe how proteins outside and inside the nucleus work together to control the position of centromeres: https://t.co/kGGJgi2x78

See the original study here: https://t.co/DFTB6aUN2I

[Nagaraj Balasubramanian @AdhesionLab]

Part of this wonderful collection @JCellBiol
https://t.co/iXW8n64Sqb

[Journal of Cell Biology @JCellBiol]

Sebellin, @CPToret, Kaksonen et al. @unige_en identify Ldb17 as the endocytic #actin on-switch in #BuddingYeast that is controlled by the coat protein Sla1 through separate recruitment and activation steps, a regulation lost in #FissionYeast. https://t.co/VZ0L66teC6

[Journal of Cell Biology @JCellBiol]

New Viewpoint: Yannick Frey and Hesso Farhan @Hesso_F_Sci discuss why competing ER export models persist and argue that vesicles, tubules, and tunnels are alternative outputs of a flexible ER export machinery. https://t.co/HlJRE7zu3p

[Journal of Cell Biology @JCellBiol]

Marco Geymonat, Marisa Segal et al. dissect a multistep phosphorylation program enforcing the confinement of Lte1 to the bud compartment of S. cerevisiae so that chromosomal segregation & #CellDivision are correctly coordinated in time and space. https://t.co/261CdyxRAT

[Journal of Cell Biology @JCellBiol]

#Optogenetic and chemical genetic tools for rapid repositioning of #vimentin intermediate filaments, developed by Milena Pasolli, Joyce Meiring (@psychescope), Anna Akhmanova and colleagues: https://t.co/IbiiW6HH13

📕 From our #Tools collection: https://t.co/IjNtEaZ4vk

[Journal of Cell Biology @JCellBiol]

Viewpoint: Zhiqi Tian, Yujie Sun, and Jiajie Diao discuss how #mitochondria supply protons to acidify #lysosomes through direct membrane contacts, and consider implications for mitochondrial quality control, aging, and disease therapeutics. https://t.co/XclU69FLHk

#Biophysics

[Journal of Cell Biology @JCellBiol]

A Biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells. New tools developed by Anoop Kumar Yadav, Abhijeet Jadhav, Jakub Svenda, @HanaSedlackova1 and colleagues https://t.co/y6ldKqhj4x

📕 From our #Tools collection: https://t.co/Nxmtkxlr53

[Journal of Cell Biology @JCellBiol]

“One of the things I like best about being an editor at the JCB is the partnership between professional and academic editors.”— Mark Peifer, University of North Carolina at Chapel Hill.

JCB is your partner for peer review. Learn more 👉 https://t.co/k3eIsUc7He