Jim Heins

LifeSci and Healthcare Comms, Kayak enthusiast, Sleep-deprived Dad Opinions expressed are my own.

[RTW Investments, LP @RtwLp]

🍄 What's found in mushrooms might be the key to defeating depression.

Chief Business Officer @stephaniesirota and Senior Research Analyst Connor Williams break down the latest in psilocybin and how perspectives are shifting from taboo recreational use to cutting-edge clinical treatment in this RTW Podcast episode: https://t.co/CBwp1vTQsJ

[Rod Wong, MD @docrodwong]

only a wk after asco and we get a glimpse of another likely breakthru for pancreatic cancer patients. tango reported that in 39 mtap deletion patients (~40% of pancreatic cancer), adding tango's vopi to revmed's daraxon or zoldon doubled the response rate u typically see with rasi alone to 64%. the daraxon combo was especially jaw dropping, with 92% n=11/12 of patients responding. the waterfall is esp pretty, only 1 patient's tumor didn't shrink. amazing leap from chemo's ~10% response rates.

https://t.co/ootOyKwOax

[RTW Investments, LP @RtwLp]

Gene therapy and gene editing: what's the difference?

Learn more in this RTW Podcast episode featuring CBO @stephaniesirota and @BeamTx CEO John Evans: https://t.co/rnruJjSu1O

[Rod Wong, MD @docrodwong]

here’s how real life trials work. take cancer. assume a drug reduces death by half (very few drugs can do that). lets say patients die in 1yr. u will want to enroll 3-400 patients, that’ll probably take 2yrs and then u’ll wait another yr for data. most cancer trials today enroll more bc 30% is often viewed as really meaningful. this works for most cancer bc it is common. now just think thru a rare disease. can’t or takes yrs to enroll that many patients. what if the disease kills u in 10yrs? trial takes a decade. k find surrogate endpoints, but what’s a universal endpoint for a disease with little data bc of how rare it is (no tumor to shrink here), might take a couple decades of failed trials just to find a good endpoint. that is the real journey patient advocacy groups and drug developers have lived, many over decades. many experienced and caring regulators lived it with them and it led to the natural conclusions - flexibility based on common sense - single arm trials, surrogates, real world evidence. real example - some enzyme replacement therapies for lysosomal storage diseases are in fact cures, completely restore normal functioning. despite that because those diseases kill u over 10+yrs several 100 patient trials failed on the best endpoints people could come up with - often how far kids could walk. imagine asking a kid to walk and then comparing that 6-12mos later. kid is tired that day, doesnt want to listen, sick etc. now imagine if the disease affects the kids brain and there is lower iq. imagine if some kids walk fine but others are in wheelchairs. this is real life in drug dev. i went to ivory tower schools, took plenty of stats (and now teach it sometimes), but u only learn judgment in real life.

[Jim Heins @JWHeins]

RT @docrodwong: here is link to release announcing new follow-up letter from rare disease coalition focused on restoring regulatory flexibi…

[RTW Investments, LP @RtwLp]

Chief Business Officer @stephaniesirota and @BeamTx CEO John Evans delve into the intricacies of next-gen gene editing in this RTW Podcast episode. Listen here to learn about Beam's work in treating diseases like Alpha-1 antitrypsin deficiency (A1AD), and more. https://t.co/BQD6ut1T6M

[Jim Heins @JWHeins]

Just got back from a two-week trip to London and Paris arranged by my better half. Saw the sights, spent time with her extended family, endured 90+ degree heat in Paris, and unexpected crowds in the Cotswolds. Overall, a great trip.

[Sanford Health @SanfordHealth]

Sanford Lorraine Cross Award winner Dr. @carlhjune says taking home the honor is like a dream. He’s grateful Sanford Health is taking the time to educate the public about achievements in medical sciences. https://t.co/2sSAybqY7B

[Jim Heins @JWHeins]

@sxbegle I am deeply sorry for your loss. Sharon was a class act and a consummate professional. I always found her reporting tremendously engaging and informative. She’ll be missed.

[Stephen King @StephenKing]

COVID has gotten entirely lost, even though it's killing 4,000 a day. We're talking about Lauren fucking Boebert and Jim Jordan instead of Joe Biden. It's still all Trump, all the time. Tell you what, the lunatics are running the asylum.

[Jo The Artist 🇳🇬🇺🇸 @joliartist]

Interesting that Alibaba founder & Chinese Tycoon Jack Ma is missing after criticising Chinese financial regulators & here in the states, @Jack Dorsey, founder of Twitter, has the freedom to suspend a government official for violating the terms of his platform.
America IS great.

[Jim Heins @JWHeins]

Dear ⁦@BetsyDeVosED⁩. A good read for you

Opinion | I see no choice but to resign from this Death Star as it begins to explode - The Washington Post https://t.co/DzqZvjHm7H

[Jim Heins @JWHeins]

@LindseyGrahamSC @senatemajldr https://t.co/CiII7eOLCO

[Keith Boykin @keithboykin]

The Trump fanatics are bad.

But Ted Cruz, Lindsey Graham, Marco Rubio, Susan Collins, Nikki Haley, Kevin McCarthy, Mike Pompeo, Rand Paul, Rick Perry, Kellyanne Conway and Kayleigh McEnany are worse.

They knew Trump was dangerous and enabled him anyway.

[Jim Heins @JWHeins]

@Kenny_Sowellfan @FoxNews Seriously? the WH’s Caputo tried to censor CDC mortality and morbidity reports on the spread of COVID. That, sir and FoxSpews, is government censorship. Twitter is a private company with terms of use, which Trump violated. BTW people are dead in case you missed it.

[Jim Heins @JWHeins]

@NikkiHaley @GovMikeHuckabee https://t.co/CiII7eOLCO

[Keith Boykin @keithboykin]

The Trump fanatics are bad.

But Ted Cruz, Lindsey Graham, Marco Rubio, Susan Collins, Nikki Haley, Kevin McCarthy, Mike Pompeo, Rand Paul, Rick Perry, Kellyanne Conway and Kayleigh McEnany are worse.

They knew Trump was dangerous and enabled him anyway.

[Jim Heins @JWHeins]

@marcorubio https://t.co/CiII7eOLCO

[Keith Boykin @keithboykin]

The Trump fanatics are bad.

But Ted Cruz, Lindsey Graham, Marco Rubio, Susan Collins, Nikki Haley, Kevin McCarthy, Mike Pompeo, Rand Paul, Rick Perry, Kellyanne Conway and Kayleigh McEnany are worse.

They knew Trump was dangerous and enabled him anyway.

[Keith Boykin @keithboykin]

The Trump fanatics are bad.

But Ted Cruz, Lindsey Graham, Marco Rubio, Susan Collins, Nikki Haley, Kevin McCarthy, Mike Pompeo, Rand Paul, Rick Perry, Kellyanne Conway and Kayleigh McEnany are worse.

They knew Trump was dangerous and enabled him anyway.

[Corey Ryan Forrester - WeLoveCorey.com @CoreyRForrester]

Hey Proud Boys and MAGA “Patriots”... what the fuck is it that this country hasn’t given you?