In this paper published today @MolecularCell, we described an experimental platform that combines single-molecule fluorescence and optical tweezers to visualize RNA polymerase transcribing DNA, which allowed us to study the dynamics of transcription elongation and termination 1/n
In this preprint, we developed a single-molecule platform to visualize individual RNA polymerases traveling on DNA, which enabled us to delineate a transcription termination process driven by polymerase collisions. Traffic jams can be useful, at least on a molecular highway!