PD-L1 blockade further restored antitumor activity.
Published in Immunobiology (Elsevier, 2026).
π https://t.co/ofW0FT8zv2
Currently based on preclinical research; clinical validation is ongoing.
#JYBioMed#LiverCancer#HCC#GammaDeltaTCells#TaiwanBiotech
Most liver cancer patients are diagnosed at late stage β when options run out.
Existing immunotherapies face challenges in the liver's naturally immune-tolerant environment.
JY BioMed is exploring Ξ³Ξ΄ T cells as a potential approach.
Ξ³Ξ΄ T cells engage cancer cells without needing specific antigen recognition.
Unmodified. No genetic engineering. Preclinical observations: cytotoxic activity against HCC cell lines, tumor growth inhibition in mouse models, no significant systemic toxicity noted.
ππ Congrats SL Science Holding (Nasdaq: SLBT) on ringing the Nasdaq bell! JY BioMed's GDT platform, licensed for glioblastoma's global clinical development, is proud to be part of this milestone.
Still preclinical, not yet approved.
https://t.co/toRE0xK5S6
We remain focused on advancing our Gamma Delta (Ξ³Ξ΄) T cell platform across scientific, academic, and regulatory fronts β exploring its potential as a complementary approach to cancer treatment.
π Read the full press release: https://t.co/VQje7wa1IR
Still in preclinical research, not yet approved by any regulatory authority. Safety and efficacy not established.
π Read more:
πhttps://t.co/pm0otR3U3t
Biotech Glossary: What is a DMF?
Before a drug enters clinical trials, the FDA reviews a document detailing raw material manufacturing and quality, called a Drug Master File (DMF).
#JYBioMed
JY BioMed has filed FDA DMFs for its UC-MSC platform and its derived exosomes, building a fully traceable quality framework from raw material to product.
#DMF#BiotechGlossary
Aug 21 marks National Senior Citizens Day. Frailty is a growing challenge in global aging care. JY BioMed's UC-MSC platform is in Phase 1 trials for frailty under FDA/TFDA oversight, backed by dual FDA DMF filings for UC-MSC and its exosomes.
#JYBioMed
Last time we introduced the three gates in our brain cancer Ξ³Ξ΄T cell research: reach, survive, maintain function. Today, digging into gate three. Why do cells struggle to hold on after breaking in? π§
Another key concept: off-the-shelf cell therapy. Ξ³Ξ΄T cells recognize tumors without matching, meaning they could be pre-manufactured and ready when needed, crucial for patients racing against time.
Because tumors actively create a low-oxygen, low-glucose, immunosuppressive environment, like a fortress built on purpose. Even immune cells that break in often lose their fighting power.
JY BioMed unveils a GDT cell therapy framework for glioblastoma, building a new paradigm for cell therapy in Taiwan. GBM is one of the most aggressive brain tumors in adults, with survival still limited. We're taking it on with Ξ³Ξ΄T immune cells. π§
Chairman Dr. Ethan Shen and CMO Dr. Benjamin Zhang, with Taipei Medical University's neurosurgery team, proposed a complete clinical development framework, published in the journal Biomedicines.
Ξ³Ξ΄T cells recognize tumors without matching, ideal for off-the-shelf therapy. The real challenge: three gates. Reaching the tumor, surviving inside it, maintaining function in a low-oxygen, low-glucose environment.
August 1 is World Lung Cancer Day. Non-smokers get lung cancer too, and not in small numbers. Lung cancer is the world's leading cause of cancer death, claiming about 1.8 million lives in 2022 alone. π«