I think there needs to be more scientific nuance here. GLP-1 receptor activation is known to dampen the midbrain dopamine system. I would hypothesize that people who have significantly faster dopamine clearance via the Val158Met polymorphism in the COMT gene (20-30% of the population are homozygous) might be more affected by the shift in dopaminergic tone and experience more than just a reduction in “food noise”. This dynamic has already well documented with anti-depressants, anti-psychotics, and stimulants.
@FBallAnalysisYT I was fully prepared for us to drag ourselves to wins *in spite of* Trevor this year.
Liam Coen has straight-up worked magic — now we’re winning *because of* him. Trevor’s cooking and it feels so good 😭🔥 #Jaguars
@KingOfVitamins The fatigue even on 1mg was crippling for me. Could barely stay awake throughout the day even with plenty of fluids, electrolytes, and at or above my maintenance calories. Everyone says it goes away after a few weeks but I couldn’t afford to find out.
@RoyalCaribbean my iPhone is getting spammed with your test notifications — I feel like I’m beta testing your next cruise! Why are these dev messages hitting my prod environment? 🚢
@heyalexfriedman I love Marc but it was cringe, to no fault of his own. I blame whoever booked him. They should’ve known that Google I/O nerds have no idea who he is or what his schtick is.
“free markets” drive progress - sellers compete with each other because buyers demand lower prices.
“captured markets”, where the government is the primary financier on the buy-side (usually at the political urging of some group of sellers), distort prices higher because the opposite is true - no matter how expensive something gets, the government will provide funding to buy it, if legislated to do so. this only yields anti-progress.
and is true in pharma and healthcare (medicare has no price negotiation incentive), education (federal student loans are handed out indiscriminately regardless of quality or performance or relative cost of education), and housing (tax credits and the federal housing loan programs, which assume home prices will always go up).
while the moral and policy intentions of these programs are sound - they provide supportive access to those in need - they are inevitably and universally inflationary which eventually makes the services LESS accessible to those in need.
no easy solution to this problem. but market incentives matter. cognizance of, and accountability for, pricing distortions should be the primary role of any agency overseeing a government service that risks these effects.