@MerseyFire We've had to cose the windows over the Mersey here in Birkenhead,
We are 4 miles away from South Liverpool, there is a significant smoke smell coming into the building since 8.30pm.
My brother sent me 'smokey-skies' photos, stretching down the east side of the Wirral
Our Fire Control operators are receiving a high volume of calls relating to smoke in the South Liverpool area.
The origin of this is wildfires in North Wales and Manchester respectively.
We would advise nearby residents and businesses to close windows and doors.
For many patients with resistant hypertension, recurrent atrial fibrillation, type 2 diabetes, heart failure, or chronic kidney disease, clinicians often respond by escalating medications, adjusting treatment targets, or adding specialists. One contributor to persistent cardiometabolic disease that clinicians may overlook is obstructive sleep apnea (OSA).
The diagnostic challenge is that many patients with OSA do not present with the classic symptoms clinicians often associate with the disorder — snoring and excessive daytime sleepiness. Instead, they may show up with difficult-to-control blood pressure, nighttime symptoms, fragmented sleep, or worsening cardiovascular disease.
“Many of these patients are not sleepy,” said Sogol Javaheri, MD, associate physician in the Division of Sleep and Circadian Rhythm Disorders at Brigham and Women’s Hospital in Boston. For patients with high blood pressure, nocturia, or disrupted sleep, “doing a home sleep test is a great next step,” she said. https://t.co/LIdtaH17CH
Beyond managing blood sugar and driving metabolic weight loss, glucagon-like peptide-1 receptor agonists are reshaping the understanding of the brain's reward pathways. Growing clinical evidence suggests these medications alter dopamine signaling to curb complex appetites, showing potential in reducing compulsive shopping, smoking, and gambling. As the therapeutic landscape expands, researchers are analyzing how modulating these neurological circuits can serve as a key adjunct to behavioral treatments. https://t.co/6Mvnm3dZF6
Watching two souls heal each other is a gift. So happy Benny found his forever home with Walter. Adoption saves more than just dogs. It saves hearts. 🐶❤️
Do you need electrolytes? .. /.How to stay hydrated in a heatwave
Andrew, I request yr help in comments of Joel's article: life endangering situation for vulnerable residential home residents overheating + dehydrating in constant day/night temperature of 30°c
@AndrewSparrow
Joel, there's a reader in the comments section of your article today requesting you, or Andrew Sparrow, or a different journalist investigate something very important.
I hope you can do so, thanks @JoelSnape
A new shot literally regrows knee cartilage.
Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).
The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.
In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.
This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.
The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.
Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.
Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.
[Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]
I’ve submitted my plan to stop fox hunting.
It closes legal loopholes used to kill wildlife:
🦊Removing exemptions from the Hunting Act
🦊Using a foreseeability test so hunts can’t hide behind smokescreens.
🦊Making it an offence to order dogs to flush out foxes
Back my Bill.
Social media trends have turned the world’s most beautiful places into endless bathroom lines at a concert, where everyone waits for hours just to take the same photo to show to people who couldn’t care less 🌎📸
Nothing captures the shallow decay of our time better than this
Barack: You told me all those years ago that you couldn’t promise me the world, but you could promise me an interesting life. Of course, you outdid yourself and managed to give me both.
Eight years in the crucible, and not once did you melt from the heat. Not once did you let it harden you. Instead, you used it to reveal your truest essence: your stubborn optimism and unflinching courage, your dazzling brilliance and unpretentious decency, your ferocious work ethic and absolutely unshakable moral fiber.