Jason Szafron

Asst Prof at CMU BME | Parker B. Francis Fellow | Interested in cardiovascular growth and remodeling, pulmonary hypertension, and engineering vasculature

[CMU College of Engineering @CMUEngineering]

.@cmu_bme's Jason Szafron recently discussed his research in computer modeling that can predict how cardiovascular disease progresses over time and how treatment can be improved.

https://t.co/3fYaBfzPLn

[CMU_BME @cmu_bme]

We are thrilled to announce the Invited Speakers for the 2024 Carnegie Mellon Forum on Biomedical Engineering! Join us on September 20, 2024 with no registration fees—just pre-register to secure your spot. Don’t miss out—register today at https://t.co/1zfGFSrbkX!

[Jason Szafron @JasonSzafron]

Forgot to tag my excellent collaborators @AleGiudici92 @abhay_br!

[Jason Szafron @JasonSzafron]

A fun project that I got to mostly work on with pen and paper! We looked at the potential for mechanical instabilities when simulating vascular smooth muscle contraction and found potential issues with simple constitutive models:
https://t.co/LCxz7lGNau

[Jason Szafron @JasonSzafron]

Excited to share our review on biomechanics in vascular graft failure! We cover both fluid and solid mechanics, as well as grafts in coronary, peripheral, and congenital heart disease applications.

[Elbert Heng, MD @ElbertHeng]

Our latest review on the hemodynamics and wall mechanics of vascular graft failure is now online! @atvbahajournals @JasonSzafron @MarsdenStanford
https://t.co/WH6VLOFpec

[Jason Szafron @JasonSzafron]

@kurt_prins @mark_toshner @jeanlucvachiery @bmprii @RRVdpool @RyanTedfordMD @GiessenPh It's also helpful to think about Fontan patients with PA remodeling. That flow is basically steady, which could also be the cause of PA remodeling. Average WSS may not be high or low but its temporal profile is different.

[Jason Szafron @JasonSzafron]

@kurt_prins @mark_toshner @jeanlucvachiery @bmprii @RRVdpool @RyanTedfordMD @GiessenPh Olufsen/Chesler have nice unsteady flow papers. I would think in CTEPH or PPAS, there could be distal remodeling with less wave propagation down the PA tree so the variance in WSS across the cardiac cycle would change.

[Jason Szafron @JasonSzafron]

@mark_toshner @jeanlucvachiery @bmprii @RRVdpool @RyanTedfordMD @GiessenPh And it looked like differences in WSS between large and small vessels could explain differential remodeling in proximal vs distal vessels. Without heterogeneity in the stimulus for remodeling, the proximal vessels didn’t tend to dilate that much, even with decent pressure rise.

[Jason Szafron @JasonSzafron]

@mark_toshner @jeanlucvachiery @bmprii @RRVdpool @RyanTedfordMD @GiessenPh In early stages of idiopathic PAH, we don’t really know. I tried to simulate initiation/progression with a multiscale model of the PA tree:
https://t.co/Qr1NglMp09

[Jason Szafron @JasonSzafron]

@mark_toshner @jeanlucvachiery @bmprii @RRVdpool @RyanTedfordMD @GiessenPh Also, depends on pruning, which we haven’t modeled. Presumably narrower vessels get pruned first, so their flow gets redirected into bigger vessels, which then increases their flow rates/WSS as more and more vessels get pruned.

[Jason Szafron @JasonSzafron]

@mark_toshner @jeanlucvachiery @bmprii @RRVdpool @RyanTedfordMD @GiessenPh Once CO starts to go down with RV failure, WSS will start to decrease but may/may not still be elevated from healthy levels depending on the relative narrowing vs flow changes.

[Jason Szafron @JasonSzafron]

@CheslerLab @RRVdpool @James_West_PhD @mark_toshner @kurt_prins @jeanlucvachiery @bmprii @RyanTedfordMD @GiessenPh One of the authors here who did flow modeling! Agree with Rebecca and Naomi on this. We were looking at PAH originating from increased flow (e.g. ASD). With increased flow and decreased radius in distal vessels, WSS increases. Becomes more complicated with other types of PH

[Jason Szafron @JasonSzafron]

We'll be studying growth and remodeling in the cardiovascular system, including pulmonary and engineered vessel evolution. Come find me at BMES this week if interested in graduate research positions at CMU!

[Jason Szafron @JasonSzafron]

Very excited to be starting as an assistant professor in Biomedical Engineering at Carnegie Mellon University (@cmu_bme) in January! Huge thanks to all my mentors (@MarsdenStanford), colleagues, and collaborators who made this possible.

[Marsden Lab @MarsdenStanford]

Our latest work from postdoc @JasonSzafron introduces a computational growth and remodeling framework for pulmonary arterial hemodynamics - just out in BMMB! Joint work with the Rabinovitch lab @StanfordBASE @StanfordChild https://t.co/zaqXUO2TA5

[Jason Szafron @JasonSzafron]

Excited to share our latest work:
A Computational Growth and Remodeling Framework for Adaptive and Maladaptive Pulmonary Arterial Hemodynamics https://t.co/THwoMaUFqK

[Vinicio de Jesus Perez, MD FAHA FCCP ATSF @Viniciodjperez]

Announcing the 2023 Keystone Meeting on Pulmonary Hypertension in New Mexico from June 25-28. The abstract deadline is March 23. For registration and agenda details, click below:
https://t.co/jpRv1HBZ0O