Dr. William Makis (MD)

Relocation to FLORIDA. Cancer Researcher

[William Makis @MakisMedicine]

NEW ARTICLE: IVERMECTIN, FENBENDAZOLE, HBOT Testimonial - 70 year old NEW ZEALAND man with Stage 4 Pancreatic Cancer given 2-3 months to live, reports after 1 year - NED! No chemo, radiation or Oncology.

Ivermectin Cancer Revolution is catching on in beautiful New Zealand! 🇳🇿😃

STORY:
70 year old NEW ZEALAND man with Stage 4 Pancreatic Cancer given 2-3 months to live

In May 2025 he started Ivermectin, Fenbendazole, HBOT.

No Oncology treatment

Results after 12 months: No Evidence of Disease (NED)

There are now dozens of testimonials of Stage 4 Cancer patients becoming NED without any conventional Oncology treatment.

These are the cases where the repurposed drug skeptics simply go silent, because they have no explanation to offer.

I always encourage Cancer patients to work with their Oncologist and consider all mainstream Cancer Treatments. Always.

But if we believe in bodily autonomy, a concept most doctors today don't believe in, there is not only a "Right to Try", but also a "Right to Choose".

Cancer patients have the right to make decisions about their treatments and their own bodies.

I have helped over 9000+ Cancer patients with repurposed drugs: Ivermectin, Mebendazole and Fenbendazole in the largest Ivermectin Project in the world.

We are bringing this Project to Florida! 😃

Please be patient during our move, as all consultations are currently halted. Our waitlist is in the thousands and growing daily.

No one else is posting repurposed drug success stories because they don't have any.

Many companies are trying to get on the Ivermectin and Mebendazole train after 2 years of my hard work, but they don't actually see or help cancer patients.

Stay away from those who are selling overpriced Ivermectin and Mebendazole kits!

[William Makis @MakisMedicine]

NEW ARTICLE: RESEARCH: NICLOSAMIDE in CANCER and other diseases - 2025 Review Paper from Henan, China

NICLOSAMIDE was approved by FDA in 1982 for treating tapeworm infections, and was designated an essential drug by WHO.

NICLOSAMIDE in CANCER Mechanisms:

1. Mitochondrial uncoupling - this is its major anti-cancer mechanism

Niclosamide acts like a mild “leak” in the mitochondrial membrane, letting protons slip across without making ATP. This increases oxygen use, lowers ATP levels, raises AMP/ATP ratio & activates AMPK (energy sensor) to inhibit mTOR (slows down cancer cell growth).

Cancer cells, which often rely on inefficient energy pathways (Warburg effect), are especially vulnerable.

This can lead to inhibition of ATP synthesis, exhausting cellular energy reserves, metabolic stress, and cell death.

2. Signal pathway modulation - It inhibits several “pro-cancer” pathways, including:

- Wnt/β-catenin (important in cancer proliferation, especially colorectal).
- mTOR (controls cell proliferation, growth and metabolism).
- Notch pathway (controls proliferation, growth, angiogenesis and cellular migration)
- STAT3, NF-κB, etc. (cancer survival, proliferation).
- Promotes apoptosis (programmed cell death) and reduce inflammation.

3. Combination with existing chemotherapies

4. Addresses Multi-Drug Resistance - by enhancing production of reactive oxygen species.

OTHER DISEASES - beyond cancer, Niclosamide’s versatility includes:

Anti-bacterial - strong in vitro activity against resistant gram-positive bacteria.

its antibacterial activity involves altering bacterial morphology, reducing intracellular ATP, and inhibiting α-HL secretion (Staph Aureus)

it inhibits all three toxins of Clostridium difficile by targeting a host process essential for toxin entry into colonocytes. In a mouse model, it reduced both primary disease and recurrence without affecting gut microbiota diversity

it demonstrates marked inhibition of vancomycin-resistant Enterococcus faecium (VRE)

It effectively eliminates H. pylori adhesion/invasion

Anti-Fungal - demonstrates impressive antifungal effects in vitro and in vivo niclosamide effectively disrupted and removed biofilms of drug-resistant Candida albicans and Candida auris by targeting mitochondrial respiration

Anti-Viral - Niclosamide could have action against SARS-CoV, MERS, Zika, Hepatitis C, Ebola, EBV

Niclosamide inhibits viral replication by reducing mTOR activation and prevents viral entry

inhibits virion production in EBV-infected cells while showing cytotoxicity and inducing cell cycle arrest

demonstrates strong activity against RSV in vitro, with a 94 % inhibition rate

suppresses Hepatitis C replication and reduces viral load

Metabolic disorders (e.g., Type II Diabetes, fatty liver): Mitochondrial effects and AMPK activation can improve energy balance and reduce fat accumulation.

Diabetes: modulates metabolic pathways, improves insulin sensitivity

Fatty liver (NASH, NAFLD) - reduces hepatic inflammation

Neuropathic Pain - reduces inflammation by inhibiting NF-kB, STAT3

alleviates pain and nerve damage

Rheumatoid Arthritis - inhibits NF-kB activation
reduces secretion of IL-6 and other inflammatory cytokines,

blocks migration and invasion of RA fibroblast-like synoviocytes.

Psoriasis - inhibits keratinocyte hyperproliferation and reduces inflammation by downregulation of STAT3, NF-kB.

Airway Diseases (Asthma, Cystic Fibrosis, COPD)

Niclosamide inhibits certain Ca-activated Cl channels involved in mucus hypersecretion & bronchoconstriction (reduces mucus production & secretion.

it blocks release of mucus and inflammatory mediators which reduces bronchoconstriction.

anti-fibrotic agent for lung fibrosis - Niclosamide downregulates expression of collagen proteins and inhibits pro-fibrotic cytokines.

Endometriosis - Niclosamide targets STAT3 and NF-kB, reduces proinflammatory cytokines and reduces endometriotic lesion growth.

ALS
In vivo experimentation involving two ALS mouse models demonstrated slowed disease progression, enhanced survival rates, and reduced motor neuron loss and muscle atrophy.

At the molecular level, niclosamide inhibited dysregulated pathways such as STAT3 and mTOR, reduced gliosis, and dampened inflammatory signaling

niclosamide has shown remarkable potential by efficiently inhibiting the expression of S100A4, a Ca2+-binding protein frequently upregulated in reactive microglia and astrocytes in ALS models. This inhibition contributes to reduced microglial reactivity, cytoskeletal changes & inflammation in ALS

Systemic Sclerosis - inhibits STAT3, AKT, and Wnt/β-catenin pathways

reduced immune cell activation

reversal of skin and lung fibrosis and reduced rate of inflammation

CONCLUSION:

Ivermectin, Mebendazole and Fenbendazole are leading the repurposed drug revolution

but Niclosamide is the most promising of the other anti-parasitics!

[William Makis @MakisMedicine]

NEW ARTICLE: IVERMECTIN and FENBENDAZOLE Testimonial - 54 year old California woman with Stage 4 NSCLC Lung Cancer 6.4x5.3cm with soft tissue metastases reports after 8 months: 93% lung mass tumor shrinkage!

STUNNING Ivermectin Cancer Testimonial! 😃

(please note that no one else posts Ivermectin Cancer success stories)

STORY:
54 year old California woman with Stage 4 NSCLC Lung Cancer with soft tissue metastases

In August 2025 she started:
Ivermectin, Fenbendazole, Tagrisso

Results after 8 months:

6.4x5.3cm Lung mass shrunk to 2.9x2.1cm = 93% Tumor Volume loss

Lung mass SUVmax 9.5 reduced to SUVmax 2.4 (resolved to background level)

Intrathoracic lymph node metastases up to 3.4cm = 100% resolved. All lymph node tumors are gone.

Soft tissue metastases = 100% resolved

For anyone who knows what Stage 4 NSCLC Lung Cancer metastatic to soft tissues is, this is a STUNNING RESULT!! 😃

The 6.4cm lung cancer mass shrunk to a metabolically inactive 2.9cm tumor that may be only a scar at this point...

and extensive lymph node and soft tissue metastases resolved completely.

When Lung cancer is metastatic to soft tissues, that's extremely advanced...

But adding repurposed drugs to conventional therapy like Tagrisso, can still reverse this very advanced disease!!

I have helped over 9000 Cancer patients with Ivermectin, Mebendazole and Fenbendazole in the largest Ivermectin Cancer Project in the world!!

We are moving this world-leading Ivermectin Cancer Project to FLORIDA!

Please be patient while we move, consultations are currently halted but the Clinic is coming soon!

God Bless...🙏

[William Makis @MakisMedicine]

NEW ARTICLE: IVERMECTIN and FENBENDAZOLE Testimonial - 71 year old Canadian man with Stage 4 Pancreatic Cancer reports after 3 months: CA19 drops 522 to 36, liver mets shrinking!!

Canadian Oncologist tells Pancreatic Cancer patient to continue Ivermectin and Fenbendazole!! 😃

(I won't disclose his location as Chinada 🇨🇦🇨🇳 authorities would throw him in a gulag and never let him out again)

STORY:
71 year old Canadian man with Stage 4 Pancreatic Cancer

In November he started:

Ivermectin, Fenbendazole, Chemo

Results after 3 months:

1. Liver metastases are shrinking

2. No metabolically active pancreatic mass (PET scan March 2026)

3. CA19-9 dropped 522 to 36

Oncologist:
“things look good, things are going in the right direction, keep doing what you’re doing”

Canadian Oncologist encourages Cancer patient to continue Ivermectin and Fenbendazole!!

This is progress, as Alberta Premier Danielle Smith recently criminalized "Right to Try" with Ivermectin and other repurposed drugs, in her unprecedented attack on terminally ill cancer patients.

I have helped over 9000 Cancer patients with Ivermectin, Mebendazole and Fenbendazole in what is the largest Ivermectin Cancer Project in the world.

We are moving this entire "Right to Try" Project to FLORIDA! New Cancer Clinic coming soon!!😃

Please be patient while we move and avoid those who are trying to imitate what we've done. There are many looking to take advantage of Cancer patients, selling overpriced Ivermectin Wellness kits, ripping people off.

Every cancer patient should be on my sub.stack, link and details are in my X bio, as is my contact info.

God bless...

[William Makis @MakisMedicine]

NEW ARTICLE: IVERMECTIN, MEBENDAZOLE and FENBENDAZOLE Testimonial - 31 year old man in POLAND with ASTROCYTOMA Anaplastic Grade 3 - reports after 3 months: STABLE!!

Ivermectin Cancer Revolution sweeps into POLAND
🇵🇱 😃

STORY:
31 year old man in POLAND with ASTROCYTOMA Anaplastic Grade 3

In December 2025 he started Ivermectin and Mebendazole (with chemo)

Results after 2.5 months:

“lesions showed slight reduction in size”

“stable size and metabolic activity”

Anaplastic brain tumors are extremely aggressive, rapidly growing and often resistant to treatment.

Did you know that Johns Hopkins was quietly issued a patent for Mebendazole in 2021 for treatment of Glioblastoma brain tumors?

I bet you didn't see that in the news.

Most Oncologists have no idea. Why? They don't read.

How many lives could have been saved since 2021?
Instead, they kept it quiet. Well, NO MORE.

The Ivermectin and repurposed drug revolution is sweeping the globe. 🇵🇱

We have helped over 9000 Cancer patients with Ivermectin, Mebendazole and Fenbendazole in the largest Ivermectin Cancer Project in the world!

This project is coming to Florida, please be patient as there are people who are trying to undermine this revolutionary work...

Don't worry, we won't let them 😉

God bless...

[William Makis @MakisMedicine]

BREAKING NEWS: Big Pharma is now posting FAKE Ivermectin, Mebendazole and Fenbendazole testimonials, using bots based in Africa!

Don't be fooled! 🤦‍♂️

Cancer patients who are exercising their "Right to Try" with cutting edge repurposed drugs like Ivermectin are under attack by Big Pharma.

Big Pharma is using bots based in Africa (often Nigeria) to post fake testimonials with fake emails. If you email them, they will steal your medical information and funds if you send them any.

Here are 8 examples.

Always check where these accounts are based. Almost all of them are based in Africa, or specifically Nigeria.

Because I have helped over 9000 Cancer patients with Ivermectin, Mebendazole and Fenbendazole in the largest and most successful Ivermectin Cancer Project in the world...

I am being heavily targeted by these Big Pharma bots! Their intent is to harm cancer patients.

Use discernment, these are all bots, scams, frauds.

Why would anyone do this?
To divert cancer patients away from real help.
To steal their medical information
To steal their funds
To burn them so they don't want to try repurposed drugs again.

ALSO:

Every website that uses my name is a FRAUD
Every Facebook account is a FRAUD
Every Telegram account is a FRAUD
Every WhatsApp, Messenger conversation is a FRAUD

Never buy Ivermectin & Mebendazole "Wellness" or "Parasite" medication kits, especially from anyone or any company on X.

[William Makis @MakisMedicine]

NEW ARTICLE: IVERMECTIN and FENBENDAZOLE Testimonial - 59 year old woman from BRAZIL with Stage 4 Breast Cancer who failed Kisqali after 12 months, reports after 2 months: Remission!!

BRAZIL 🇧🇷 embraces the Ivermectin Cancer Revolution!! 😃

STORY:
59 year old woman from BRAZIL with Stage 4 Breast Cancer first diagnosed in 2018. In 2024 her cancer spread to liver and gallbladder.

She took Kisqali for 1 year but progressed with cancer growth in the liver.

In November 2025 she started:

Ivermectin + Fenbendazole + Enhertu

Results after 2 months: REMISSION!!

This is an incredible story of repurposed drug synergy with Targeted Therapy!

The Ivermectin Cancer Revolution is sweeping the globe. There is no stopping it.

I have helped over 9000 Cancer patients with Ivermectin, Mebendazole and Fenbendazole in the largest Ivermectin Cancer Project in the world

We are moving this Ivermectin Cancer Project to FLORIDA, where New Cancer Clinics will be established very soon!! 🙏

God Bless...

[William Makis @MakisMedicine]

NEW ARTICLE: RESEARCH: MEBENDAZOLE in Cancer - 2025 Iran Paper - How Mebendazole overcomes Cancer Drug Resistance!

2025 Aliabadi et al - Critical dysregulated signaling pathways in drug resistance: highlighting the repositioning of mebendazole for cancer therapy

Cancer drug resistance significantly reduces the effectiveness of current anticancer treatments

This highlights the need for developing new multi-targeting drugs that are more cost-effective, have fewer side effects, and remain effective against cancer.

Drug repurposing offers a promising solution over expensive targeted therapies.

Repurposing Mebendazole: it’s already been given to millions of people at high doses with a very good safety record, repurposing it for cancer is much faster and cheaper than inventing a brand-new drug.

How MEBENDAZOLE Fights Cancer and Cancer Drug Resistance.

This review breaks down six key ways Mebendazole attacks cancer.

Mebendazole hits all of them at the same time, which is why it may overcome resistance better than single-target drugs:

1. Disrupts the cancer cell’s skeleton (microtubules)

MBZ binds to the same spot on tubulin that the cancer drug colchicine uses. This stops cancer cells from properly dividing (they get stuck in the G2/M phase of the cell cycle and eventually die).It’s similar to some existing chemotherapies but appears safer.
Starves the tumor of blood supply (anti-angiogenesis)

2. Tumors need new blood vessels to grow and get nutrients. MBZ blocks a key signal called VEGFR2, so the tumor can’t build those vessels.

3. Triggers programmed cell death (apoptosis)

MBZ tips the balance of proteins inside the cell (raising “death-promoting” ones like Bax and p53, lowering “survival” ones like Bcl-2 and XIAP). This activates enzymes called caspases that make cancer cells commit suicide in an orderly way.

4. Forces cells to “eat” themselves (autophagy)

Autophagy is the cell’s recycling system. MBZ can ramp it up so cancer cells digest their own damaged parts until they die or become easier to kill.

5. Mebendazole wakes up the immune system

It shifts immune cells called macrophages from a “tumor-friendly” state (M2) to a “tumor-killing” state (M1 type). It also increases signals that attract other immune attackers and works especially well when combined with radiation.

6. Stops cancer from spreading (anti-metastasis and MMP inhibition)

Cancer cells use enzymes called matrix metalloproteinases (MMPs) to chew through surrounding tissue and travel around the body.
MBZ blocks them.

Additionally, MBZ calms down several overactive growth pathways that cancers use to survive and resist drugs (examples: Hedgehog, ERK/MEK, MYC, NF-κB, AKT, etc.).

What the evidence shows

Lab dishes (in vitro): Very low concentrations (often under 1–5 micromolar) kill or slow down breast, colon, lung, stomach, ovarian, melanoma, and brain cancer cells. MBZ works even better when paired with standard chemo or radiation.

Mice (in vivo): Oral doses (10–50 mg/kg) shrink tumors, reduce the number of polyps in colon cancer models by up to 90 %, slow metastasis, and improve survival. Tumors weighed far less (e.g., one study: ~2 g vs. 12 g in untreated mice).

Humans (early clinical trials): Small studies in brain tumors (Glioblastoma) and gastrointestinal cancers showed it is safe even at high doses (up to 4 g/day).

One glioma trial reported median survival around 21 months when combined with standard treatment.

The main practical challenge (and the fix)

MBZ doesn’t dissolve well in water and isn’t absorbed very efficiently from the gut into the bloodstream or tumors.

The review discusses new “drug delivery” solutions that researchers are testing:

polymeric nanoparticles
nanostructured lipid carriers
micelles
nanosuspensions

These make Mebendazole more soluble, help it reach the tumor, and may let doctors use even lower doses.

Main Takeaways from the Paper:

Mebendazole is a strong candidate for drug repurposing in cancer because it:

1. attacks cancer from many angles at once (great for beating resistance),

2. is already proven safe and cheap,

3. works in many different cancer types in the lab and in animals,

4. shows early promise in people,

5. and can be combined with existing treatments.

CONCLUSION:

Overall, the paper is optimistic: Mebendazole could become a low-cost, low-toxicity addition to the cancer-fighting toolbox, helping patients whose tumors have stopped responding to standard therapies.

In short, this review makes a detailed, evidence-based case that an old “worm pill” might help solve one of the toughest problems in modern cancer treatment - drug resistance - by hitting the cancer where it hurts in multiple ways at the same time.

[William Makis @MakisMedicine]

Governor DeSantis is also fighting for Cancer patients

and has taken actions to turn FLORIDA into a global leader for Cancer Innovation and Cancer Research.

This will become International news over the coming months and years as Americans will witness advancements in Cancer in Florida that other States and countries can only dream of.

I agree with @RWMaloneMD, Governor DeSantis is a brilliant mind and a visionary and Florida will soon become the epicenter of revolutionary Cancer Care and medical freedom in general.

[William Makis @MakisMedicine]

BREAKING NEWS: Mayo Clinic is offering me an "Executive Director" position for up to $400k 😃

Oh and they're not the only one. My email inbox is suddenly filling up with Executive job offers from several big Pharmaceutical companies.

So this is what I get for helping 9000+ Cancer patients with Ivermectin & Mebendazole and leading the largest Ivermectin Cancer Project in the world?

After talking about a New Florida Cancer Clinic? 🤔

If they can't sabotage me, they'll just buy me out? 💵

I have to admit, it is mildly amusing.
Ten years ago, I may have jumped at something like this. It's almost tailor made for me.

But at this stage of my life...can't say I felt even a hint of temptation. They really don't know me very well 😃

Sorry, Mayo Clinic.
I'm building a Cancer Center in Florida.
It's going to be a bit different from yours. 😉