Jacek Jemielity

Professor of bioorganic chemistry at University of Warsaw.

[Ella Marushchenko @Ella_Maru]

New Cover from Ella Maru Studio!
Advanced mRNA Cap✊

This paper describes AvantCap - a chemical modification of messenger RNA 5' end that confers superior translational properties to mRNA. The design of AvantCap was inspired by a naturally occuring modification of mRNA cap - so called m6Am mark. @JoannaK_UW, @JemielityLab, @JeffMugridge from @UniWarszawski and @UDelaware found that mRNAs carrying AvantCap produce more protein in vivo than reference mRNAs, while mRNAs encoding tumor antigens show superior activity in therapeutic settings as anticancer vaccines. Therefore, AvantCap has tremendous potential to advance the therapeutic mRNA field.

Learn more: https://t.co/iJv0SeJbc4

#RNAbiology #mRNA #RNA #vaccines #molecular_biology #ella_maru_studio #journalcover #phdlife #phd #sciencegirl #scicomm #womaninscience #medicalartist #sciencegirl #biology #chemistry #sciart

[Jacek Jemielity @JemielityLab]

Biology-inspired modification of the 5' end of mRNA with high therapeutic potential. Probably the most important research in my life so far.

[J. Am. Chem. Soc. @J_A_C_S]

Trinucleotide mRNA Cap Analogue N6-Benzylated at Site of Posttranscriptional m6Am Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo | JACS @UniWarszawski @DominikaNowis @JemielityLab @JoannaK_UW #RNA https://t.co/xkT9nArpLi

[Jacek Jemielity @JemielityLab]

@SteDziembowski @adamgendzwill Jak widzisz ambicje są raczej umiarkowane :) Ale dzięki, będę pamiętał

[Jacek Jemielity @JemielityLab]

A good home for our joint research! Thank you again for the exciting collaboration! @NatureChemistry @BaranLabReads @UniWarszawski @JoannaK_UW

[Baran Lab @BaranLabReads]

The final version of this study has appeared today in @NatureChemistry : https://t.co/c8UHok5gVz

[Jacek Jemielity @JemielityLab]

A summary of our research on therapeutic mRNA published in Accounts of Chemical Research. Topics very timely lately :). Congratulations to @kkariko and @WeissmanLab !!!
https://t.co/B3zeXkF4ys
@UniWarszawski @JoannaK_UW

[Jacek Jemielity @JemielityLab]

Thank you @JeffMugridge for your visit and sharing with us the great science!

[Jeff Mugridge @JeffMugridge]

I had a great time visiting our amazing collaborators @JemielityLab, @JoannaK_UW, and their teams at @UniWarszawski recently! Looking forward to more science and hopefully seeing more of Warsaw on future visits! Thanks for hosting me!

[Jacek Jemielity @JemielityLab]

Proud of exploRNA team

[Business Insider Polska 🇵🇱 @BIPolska]

Polska spółka biotechnologiczna ExploRNA Therapeutics otrzymała finansowanie od Fundacji Billa i Melindy Gatesów na dalszy rozwój swojej autorskiej technologii modyfikacji mRNA. Pozwala ona na opracowanie nowych terapii, takich jak szczepionki… https://t.co/QxI8SSfiPw

[Jacek Jemielity @JemielityLab]

Thanks Phil and the team for a great collaboration! @JoannaK_UW @BaranLabReads

[Baran Lab @BaranLabReads]

The utility of such constructs is exemplified through the extraordinary work of our collaborators whom we are honored to work with: Profs. Jacobson (NIH), Müller (UBonn), Kowalska (UWarsaw), and Jamielity (UWarsaw)

[Baran Lab @BaranLabReads]

Today in @ChemRxiv (https://t.co/cKhuyQGCzu): Democratized access to stereo pure thioisosteres of life's building blocks with promising translational potential in medicine. New reagents and a completely different strategy coupled to some amazing collaborators enabled this study.

[Rodrigo Reis @Rodrigo_S_Reis]

2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion
NAR
https://t.co/LWPVZ80JGf

[Joanna Kowalska @JoannaK_UW]

The recruitment is open one more week. Don't forget to apply!

[Jacek Jemielity @JemielityLab]

We published in JOC a procedure for modifying commercially available building blocks for synthesis of oligonucleotides. The method provides quick access to tools for studying post-transcriptional modification of RNA. @JoannaK_UW, @UniWarszawski @JOC_OL
https://t.co/2OKVIjSpk7

[Joanna Kowalska @JoannaK_UW]

We are looking for two post-docs to work on an exciting project aimed at finding new ways to improve therapeutic mRNAs! If you would like to join our https://t.co/LGwqajbZVg group, please apply.
https://t.co/7sygtZyJtD
Retweets appreciated.
@PostdocP @PostdocJobs @JemielityLab

[J Org Chem/Org Lett @JOC_OL]

The first nucleosides for the SuFex reaction – useful tools in chemical biology and drug discovery published in #OL by @JemielityLab. Learn more here: https://t.co/L1FygK9Xjo

[ChemEurJ: Chemistry - A European Journal @ChemEurJ]

Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties (Jemielity, Kowalska et al.) @JemielityLab @JoannaK_UW #OpenAccess https://t.co/kboE4TGmPc

[Joanna Kowalska @JoannaK_UW]

We are looking for post-docs interested in working on novel therapeutically relevant mRNA modifications in our https://t.co/MtcMeJhOyh group. Retweets appreciated! https://t.co/udDWuTtnga

[Pharmaceuticals MDPI @Pharmaceut_MDPI]

We have #RecentlyPublished an #aricle by Dorota Kubacka and her associates: #Substrate-Based Design of Cytosolic Nucleotidase IIIB #Inhibitors and #Structural Insights into Inhibition Mechanism

Full text is available at:
👉https://t.co/tT3gz8Y59x

@UniWarszawski @MPI_Biochem

[Pharmaceutics MDPI @MDPIpharma]

#MDPIPharmaceutics 📗
"Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′ cap Analogs: Synthesis and Evaluation as Modulators of Translation" by Radoslaw Wojcik et al.

Full paper at：https://t.co/P4z0BaLqut

[FNP Foundation for Polish Science @FNP_org_pl]

Fundacja na rzecz Nauki Polskiej i Nagrody FNP mają 30 lat! Gratulujemy tegorocznym laureatom z @PAN_akademia i @UniWarszawski i kontynuujemy naszą misję wspierania najlepszej nauki w Polsce. #30latFNP, #NagrodyFNP, szczegóły na stronie:👉https://t.co/ETKwdUYYwQ

[Jacek Jemielity @JemielityLab]

Our method for efficient double labeling of mRNA and its diverse in vitro and in vivo applications published in Nucleic Acids Research. I am very proud of this work.
https://t.co/ee0IIe35GW