“Protected time” for clinical investigators in medical oncology: The persistent gap between expectation and reality - Sedrak - 2026 - Cancer https://t.co/mjjblGpRJQ
1/ Thanks @BloodPortfolio for this Point-Counterpoint with @JanakiramMurali. Open access!
How do we decide on cilta-cel vs bsAbs at first relapse in myeloma?
My abbreviated arguments in favor of CAR-T:
1️⃣ CAR-T works very well in CD38-refractory dz (see RW data from @hhashmi87 et al, or as-treated CARTITUDE-4)
2️⃣ Long-term QOL advantage, with ⬇️ long-term time tox with CAR-T vs bsAbs ± dara + continuous IVIG
3️⃣ PFS2 of CAR-T to bsAbs likely will still beat bsAbs to CAR-T sequencing-wise unless bsAbs are time-limited
Of course decision-making needs to be individualized!
JNJ-5322 (BCMAxGPRC5DxCD3 trispecific) in MM: @richaparikh36 (@WinshipAtEmory) shows 100% ORR & ≥CR 88.9% at 18-mo FU; 12-mo PFS 95%; median PFS not reached; prophylactic tocilizumab cuts CRS to 20% with no ICANS; MRD-neg 100% - promising next-gen T-cell engager. #DAVAWhistler
My thoughts on the selection of the best therapy for a myeloma patient experiencing a first relapse: cilta-cel versus teclistamab plus daratumumab?
#mmsm https://t.co/pFlmtXi9AJ