Our new paper @AJPLung provides a lentiviral toolkit to monitor airway epithelial cell differentiation using bioluminescence. @Jess0rr developed these during her PhD @lungsforliving... 🧵(1/5)
https://t.co/yyCO8gzTvK
🚨 New preprint!
With @lungsforliving and @UKRMP_ECE colleagues, we performed phenotypic screening to identify compounds that might promote lung regeneration by inducing primary airway basal cell proliferation.
https://t.co/TtGlDCsJSO
Here's a 🧵 breaking down our findings:
Our new paper @MolTherapy provides proof-of-concept for a combined cell and gene therapy for airway epidermolysis bullosa (EB).
With colleagues @GreatOrmondSt, we investigated airway disease in EB, a group of rare genetic disorders involving defective cell adhesion 🧵... (1/8)
Delighted to share this work!
We also created an editable construct if you’d like to track other cell type-specific gene expression in your own cell culture system 👩🔬
🧵 The preprint for our work using lentiviruses to monitor airway epithelial cell differentiation using bioluminescence is now available on @biorxivpreprint! (1/5)
Absolutely delighted to share our paper published today in @SciImmunology in collaboration with @teichlab. Huge congratulations to amazing co-first authors @DrJoBarnes, @masahiroy15, @PengHeCam! Team science!
https://t.co/748YBPXk0o
'A New Climate: Why we need to act, and what we need to do'. Professor Hugh Montgomery
https://t.co/EE20jfxjnm @uclmedsci@domearlycareers @SustainableUCL
RESEARCH: New work with @paolodecoppi and @Dr_ClaireSmith@UCLchildhealth out @Biomaterials_. We perform decell and recell of rat lungs with human airway basal cells, creating a novel RSV infection model. Introducing human neutrophils to the system is also feasible. 1/2
We may be biased, but this takes some beating for the location for a conference dinner! Cruising on the Spirit of Ethan Allen on Lake Champlain. #networking#VTStemcell2023
With @SwantonLab, we've developed a new python package - PATHOverview - to semi-automatically compile #digitalpathology#NanoZoomer images into publication ready figures: https://t.co/fvm9iFL2Ot
The first output was published today @FrontOncology: https://t.co/A7tGOez5iY
Thank you @DoM_UCL for the prize for best PhD poster at the UCL Division of Medicine Retreat!🏅Was great to share the project with the fantastic researchers at #domretreat2023
👏🏼👏🏼Congratulations to @DrPujaMehta1 and @OliviaBracken1 (best PhD and Postdoc oral presentations) and to @Jess0rr and @peppeercoli (best PhD and Postdoc poster presentations) at the #domretreat2023 today!
Great being able to share this work with @Dr_ClaireSmith@soichishibuya@ElvassoreL@robhynds@lungsforliving Fabio Tommasini, Federica Michielin, Alessandro Pelegatta, and many others Lung viral infection modelling in a bioengineered whole-organ https://t.co/nXcbLB6RYH
PRE-PRINT: @robhynds’s postdoc work on lung cancer patient-derived xenograft models is up @biorxivpreprint. @SwantonLab demonstrate the potential of multi-region PDX derivation to recapitulate intratumour heterogeneity in model systems #PDXmodels