BioCheLa - UNAM

A research group led by Dr. Arturo Jimenez Sánchez, developing small molecule fluorescent probes for imaging intracellular communication at UNAM in 🇲🇽

[BioCheLa - UNAM @JimenezLab1]

AztecBleb probes revolutionize the study of bleb dynamics & integrin-ECM interactions! 🔬 Real-time visualization unlocks new insights into cytoskeleton-ECM interplay during migration & blebbing processes. #CellBiology #Microscopy #BlebDynamics

[BioCheLa - UNAM @JimenezLab1]

That kind of PI…

[BioCheLa - UNAM @JimenezLab1]

@EdenMoralesNar1 @iquimicaunam Gracias Eden 🙏

[BioCheLa - UNAM @JimenezLab1]

I have received so many heartfelt words from students and the chemistry community at the @iquimicaunam It has been an incredible honor to be part of this 85 Aniversary and to strive to live up to the standards of such an amazing institute. A place I proudly call home. ❤️

[BioCheLa - UNAM @JimenezLab1]

@coincoalquiler 3… single “cholesterol tag.”

Which leads to the question that still fascinates me: is there really such a thing as a genuine chemical vector for lipid droplets, or are we always exploiting physicochemical partitioning instead?

[BioCheLa - UNAM @JimenezLab1]

Happy to share our collaborative work on cholesterol-derived NIR Aza-BODIPY probes for lipid droplets. Given the lack of well-established chemical vectors for LDs targeting, this remains a field with significant opportunities and a long road ahead. https://t.co/2BD7hUeOp5

[BioCheLa - UNAM @JimenezLab1]

@coincoalquiler 2. the Aza-BODIPY core, molecular conformation, lipophilicity/partition coefficient, and probably the geometry of the interactions all contribute to the final intracellular distribution. In other words, it’s an emergent property of the complete molecule rather than a…

[BioCheLa - UNAM @JimenezLab1]

@coincoalquiler 1. Great question! Actually, we don’t think cholesterol itself is the targeting vector. Free cholesterol is quite promiscuous and traffics through multiple membrane systems. Our view is that LD localization emerges from the whole molecular architecture: the cholest fragment…

[BioCheLa - UNAM @JimenezLab1]

@Cfata_Unam @avila_remy @EdenMoralesNar1 @mota_josue @RicardoAncheyta @AlvaroRuz15 Muchas felicidades Eden! Es un reconocimiento muy merecido. Enhorabuena

[Centro de Física Aplicada y Tecnología Avanzada @Cfata_Unam]

Nuestro investigador ha sido reconocido como ScholarGPS® Top Scholar en la especialidad de Biosensores, colocándose entre el 0.5% de los mejores expertos a nivel mundial 🌍
👏 ¡Enhorabuena!
🔗 https://t.co/ixXWY2SDkV

[BioCheLa - UNAM @JimenezLab1]

@TripletStateGuy @Adriperez3108 @Richard47981678 @iquimicaunam Gracias Ricardo! Abrazo grande

[BioCheLa - UNAM @JimenezLab1]

Happy to share our paper on Selective lysosomal H2O2–ROS imaging - was published on RSC Advances. Thanks to @Adriperez3108 @Richard47981678 and Nitzya. @iquimicaunam BioCheLa https://t.co/kwv4vS3UVf

[Eden Morales-Narvaez @EdenMoralesNar1]

🚀 Our paper on smartphone-based colorimetric sensing is now a Highly Cited Paper (top 1% in Chemistry, Web of Science) 🎉📱 We show that using CIELAB color space enables reliable, illumination-invariant sensing—no bulky setups needed.
https://t.co/XkNZTXAJLg
@Cfata_Unam

[BioCheLa - UNAM @JimenezLab1]

Excited to share our new Perspective: “Molecular Probes for Tracking Reactive Oxygen Species at the Organelle Interface.” Exploring how chemical design enables precise ROS mapping across subcellular boundaries. @Daniela_Avce @iquimicaunam
https://t.co/jiBRrUCch8

[Wei Gao @WeiGaoLab]

New in Nature Sensors, we report EBClite, an ambient light-powered smart mask for continuous and sustainable biochemical sensing in exhaled breath. Cheers to @Heng_Wenzheng @Caltech @NaturePortfolio
https://t.co/QN8H5pannb

[BioCheLa - UNAM @JimenezLab1]

@MolinaGroup 🤣

[BioCheLa - UNAM @JimenezLab1]

Excited to share our new review, now out in Biosensors and Bioelectronics: X! The convergence of advanced probe chemistry, optics, and machine learning is opening a new era in precision medicine. @iquimicaunam https://t.co/8QBlwI8J4L

[BioCheLa - UNAM @JimenezLab1]

@WichoBelmonte @ChemPhotoChem @Navarro0502 Felicidades José Luis

[BioCheLa - UNAM @JimenezLab1]

Happy to share our recent contribution from on Erlotinib APIs Conjugates Revealing Dual Compartment Access and Targeted EGFR Suppression | ACS Chemical & Biomedical Imaging. 💪BioCheLa 💪@iquimicaunam @UNAM_MX https://t.co/y9iOEATO1C

[BioCheLa - UNAM @JimenezLab1]

@EdenMoralesNar1 @ACSPublications Gracias Eden! Pásala chévere!!

[BioCheLa - UNAM @JimenezLab1]

Christmas acceptance news! Our manuscript “Lysosome-Directed Erlotinib Conjugates Reveal Dual-Compartment Access and Targeted EGFR Suppression” is now accepted in Chemical & Biomedical Imaging @ACSPublications
DOI: 10.1021/cbmi.5c00208
Onward to smarter targeted imaging &therapy