Friend of mine told me today that I seem "easily manipulated by dogs" which is one of the most ice-cold insults I've ever received. This was because I gave her dog a treat
Oooooohhhhh - nice paper reinforcing the complexities of PD-1 blockade and impact on Treg populations in cancer. Part of an expanding landscape that highlights that Tregs are T cells too - and subject to regulation. @JoeFlowImmuno
https://t.co/Kbw5mb8hnC
Happy to share the newest paper from our lab. Led by technician extraordinaire Aidan Tousley (soon to be an MD/PHD student!), this manuscript details our attempts to reimagine the structure of CARs to improve their specificity and efficacy. https://t.co/EKzcX4JaFP
Tregs are T cells too!
IL-10 secreting effector Treg cells express the immune checkpoints PD-1 and CTLA-4, and proliferate with combination blockade compared to non-Tregs - without changes in IL-2!
https://t.co/FrTlIt9Zwx
Maybe not everyone thinks about what limits Treg cell populations. Its more than just IL-2 availability. @JoeFlowImmuno shows PD-1 and CTLA-4 exert additive control of effector regulatory T cells at homeostasis https://t.co/Qn1IlkM1mC
This thread is for people with stiff or painful necks.
The most vital step to relief is finding and addressing the root causes.
Here are six potential sources fuelling your problem: