José Manuel

Proyectos de salud y ejercicio físico

[Iñigo San Millán @doctorinigo]

🚨 🔬RIGHT OUT OF THE OVEN!. Our last study published today!.

Even in apparently healthy people, sedentarism was associated with a major impairment in mitochondrial function.

We used skeletal muscle biopsies, high-resolution mitochondrial respirometry, metabolomics, proteomics, targeted mitochondrial lipidomics including cardiolipin analysis, ROS assessment and ¹³C tracer-based oxidation flux analyses to examine how sedentarism affects mitochondrial function, substrate oxidation and cellular fuel metabolism.

1) One of the key findings was an almost 50% reduction in MPC1 (the mitochondrial pyruvate carrier) that allows pyruvate to enter the mitochondria and be oxidized.

Our data suggests that glucose dysregulation could happen at the mitochondrial level, years before insulin resistance happens at the surface level, leading to type 2 diabetes. I call this an "inside-out" theory of glucose dysregulation.

2) The second important finding is that we can also correlate the mitochondrial dysfunction, metabolic flexibility and decrease in MPC1 with cardiopulmonary exercise testing (CPET) plus lactate testing, which I call "CPELT" -cardiopulmonary exercise lactate testing. With this test we could indirectly assess in a non-invasive way, mitochondrial dysfunction in healthy people years before metabolic disease shows up and intervene with specific exercise prescription and nutrition.

Link to the study here!👇
https://t.co/338KE6plE5

#Mitochondria #MetabolicHealth #PhysicalActivity #Sedentarism #MPC1 #Metabolism #Healthspan #Longevity #DiabetesPrevention #HealthyAging

[Pablo Malo @pitiklinov]

Esta carta de Rod Wilson al Wall Street Journal sobre el tema de las prohibiciones de redes a los jóvenes me parece de lo más sensato que he leído al respecto. La pongo entera porque es cortita:

La prisa global por prohibir el acceso de los adolescentes a las redes sociales es emocionalmente comprensible -y estratégicamente miope (“Las prohibiciones de redes sociales para jóvenes ganan impulso en todo el mundo”, Portada, 19 de febrero).

Las prohibiciones parecen contundentes, pero evitan la verdad más dura: el entorno digital no es temporal y la adolescencia no puede posponerse hasta que resulte conveniente para los adultos. No estamos criando niños para un mundo sin algoritmos. Los estamos criando para un mundo moldeado por la inteligencia artificial, la visibilidad pública y la comparación constante. Eliminar el acceso no construye resiliencia, juicio ni autorregulación. Solo retrasa el momento en que esas habilidades serán necesarias, a menudo hasta que la influencia parental ya se ha debilitado. La historia demuestra que la prohibición rara vez genera madurez.

Los adolescentes necesitan adultos dispuestos a establecer límites claros, aplicar consecuencias, enseñar alfabetización digital y modelar ellos mismos un uso disciplinado de la tecnología. Necesitan escuelas que enseñen la atención como una habilidad. Necesitan responsables políticos que exijan transparencia y barreras de protección a las plataformas que monetizan el engagement adolescente.

El verdadero problema no es si los adolescentes tienen acceso a las redes sociales. El problema es si estamos dispuestos a hacer el trabajo de criarlos dentro de ese entorno. Una prohibición traslada la responsabilidad hacia fuera, a gobiernos y empresas. Pero la atención, la disciplina y el juicio se aprenden en casa. Si queremos adultos que contribuyan en lugar de dependientes digitales, deberíamos centrarnos menos en proteger a los adolescentes del mundo moderno y más en formarlos para navegarlo.

Rod Wilson

[Dustin @r0ck3t23]

For centuries, two things determined your economic fate.

What you knew. And how much capital you controlled.

The entire architecture of professional value built on those two pillars.

Pal: “Everything we’ve talked about is based on scarcity of knowledge. It’s either scarcity of knowledge or scarcity of capital. Those two things.”

You weren’t paying a lawyer for their time. You were paying for the vault.

The decade they spent unlocking information you couldn’t access yourself. The doctor, the accountant, the consultant, the analyst. Same model. Different vault.

The scarcity of knowledge was the entire business.

Pal: “What you’ve created is infinite knowledge. Knowledge is now worth zero. People can’t see it yet, but it’s going to be worth zero. This is like water.”

When something becomes infinite it stops being valuable. That’s not opinion. That’s how economics works.

Water is essential to survival and costs almost nothing because it’s everywhere.

Knowledge just became water.

The vault is open. The door is gone. Anyone with a prompt gets the same answer a decade of study used to produce.

Pal: “It’s going to break the entire economic model for good and for bad. It’s going to change our understanding of how society functions, what humans do. It’s going to change our understanding of what humans are.”

Read that last sentence again.

Not what humans do for work. What humans are.

The question of human identity has been tied to the scarcity of our minds for all of recorded history. We were the ones who knew things. We were the vault.

Remove that and the question of what we actually are has no answer yet.

Pal calls this the single greatest innovation in human history. The only comparison he reaches for is splitting the atom.

The atom gave us energy so concentrated it ended a war and rewired geopolitics in three days.

This is giving us intelligence so concentrated it’s ending the knowledge economy and nobody has fully processed what comes after.

The professionals who built careers on information retrieval are not losing jobs to cheaper labor.

They’re losing the foundational premise that made their expertise valuable. That’s a different problem.

Cheaper labor gets displaced. Displaced premises don’t come back.

What survives is judgment. The ability to ask the right question, synthesize the infinite, and hold liability for the result.

Not knowing. Deciding.

Most people still act like the scarcity exists. Still accumulating knowledge AI replicates instantly. Still building expertise behind barriers that no longer hold.

Optimizing for a world that’s already gone.

This didn’t gradually disrupt industries. It eliminated the foundation they were built on.

The knowledge worker was the dominant economic figure of the last century.

The vault is empty now.

[Pablo Grueso @PabloGrueso]

Foco, supervivencia y exponencialidad.
La metáfora del emprendedor.

[#metoo hospitales @Ptoazulsanidad]

El gen egoísta de la profesión médica. Nuevo artículo de opinión. #estatutomarco #vocación

[Marisquiño @omarisquino]

The Rock on Top 🪨🖤🐙 La bola de granito rosa de Porriño es la guinda del pastel, pero en versión OM ❤️‍🔥 Una pieza de la mano de Godoy Maceira que conecta la cultura urbana con el patrimonio de Galicia ⚪🔵

📆 7-10 Agosto
📍 Vigo

#Marisquiño #Skateboarding #ActionSports #Skate

[José R. Juanatey @JoseJuanatey]

Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | NEJM ejercicio como tratamiento para prolongar la vida en pacientes con cáncer! Si fuese un fármaco estaríamos todo el día hablando de él!! ⁦@secardiologia⁩ ⁦@SIAC_cardio⁩ https://t.co/PdbxqUsZeW

[Manel Valcarce @manelvalcarce]

✍ La salud y el bienestar, tanto físico como mental, son clave para la felicidad, según Ipsos. Un 25% destaca la importancia del bienestar mental y un 22% del bienestar físico vía Statista

#Salud #Bienestar #Felicidad #Ipsos #SaludMental #BienestarFísico

[FNEID @fneid_es]

En una entrevista con Gym Factory TV, Alberto García abordó los posibles efectos de una regulación que limite el ejercicio profesional de los titulados de Formación Profesional.

Entrevista completa: https://t.co/6xRw8HZVQK 

#FNEID #Fitness #EmpleoDeportivo #GestiónDeportiva

[Consejo COLEF @ConsejoCOLEF]

🫱🏻‍🫲🏼 Clausura del Ier Foro de Colaboración Público-Privada en los Servicios Deportivos y se convierte en permanente‼️

El proyecto subraya la necesidad de mejorar la contratación pública para garantizar servicios de calidad, condiciones laborales dignas y estabilidad.

+ℹ️👇🏻

[José Manuel @Joseamado68]

Todo suma para o plan plan 2M : lograr
2millons de galeg@s practicando deporte 💪

[Deporte Galego @deporte_galego]

☑️ Neste 2025 a @Xunta investirá 2 M€ para o desenvolvemento de actividades deportivas e núcleos de adestramento deportivo especializado

💪 Unha actuación para continuar fomentando e fortalecendo o deporte na nosa comunidade

[Deporte Galego @deporte_galego]

☑️ Neste 2025 a @Xunta investirá 2 M€ para o desenvolvemento de actividades deportivas e núcleos de adestramento deportivo especializado

💪 Unha actuación para continuar fomentando e fortalecendo o deporte na nosa comunidade

[Víctor San @victorsantana]

@arjona_manu posible relación, con lo que comentamos sobre cómo una dieta muy estricta o un entrenamiento excesivo pueden afectar al estado anímico desde lo fisiológico y no desde lo mental.

[EFE Deportes @EFEdeportes]

💰 11,5 M€ en 27 ediciones. El Plan Fundación Olímpica (PAO) de Andalucía ayuda a captar el talento y crecer a sus deportistas. Isabel Sánchez, desde la Junta de Andalucía, traza la hoja de ruta del PAO.

💼#EFESportBusiness
📩 https://t.co/DU3fkFkIs7
https://t.co/Vw79NDYsrf

[José Manuel @Joseamado68]

@david_suarezma @Cluster_deporte Las dinámicas “virtuosas” de las entidades (sean sociales o empresariales) siempre se producen en entornos:
- “propósito común compartido”
- “generosidad en las aportaciones”
- “sentimiento de pertenencia a un colectivo con un propósito en el que crees ”
🥰

[Iñigo San Millán @doctorinigo]

2/2 The link to our study https://t.co/CdH1APv68r and a simple depiction through these 2 pictures 👇

[José Manuel @Joseamado68]

@david_bonilla @cesarastudillo Y antes el Mitsubishi Pajero

[Iñigo San Millán @doctorinigo]

On aerobic glycolysis vs anaerobic glycolysis.

This terminology has existed since the beginning of times and ingrained in every physiology, biochemistry and medical textbook.

According to this terminology, aerobic glycolysis is the oxidation of glucose to pyruvate in cytosol then to Acetyl-CoA in mitochondria in the presence of oxygen. Anaerobic glycolysis is the reduction of pyruvate to lactate under “anaerobic conditions”.

However this terminology is wrong as lactate is the real end-product of “both” glycolysis. Over the last 50 years Dr. George Brooks has worked on this and proven it.

The ratio of lactate to pyruvate at rest is ~30-40 and at high intensity exercise is up to 500.
So, even during resting conditions, the production of lactate is significantly higher than the production of cytosolic pyruvate…Hence, glycolysis should be just that, glycolysis…

This wrong terminology has penetrated into so many fields in medicine and biology as well as exercise physiology and training leading to terms like “aerobic threshold” and “anaerobic threshold”. Simply, they don’t exist as they are portrayed, since both metabolic events are under fully aerobic conditions and also lactate is the main end-product over cytosolic pyruvate.
The pure anaerobic threshold is the change from glycolysis to ATP-PC system during sprinting where anaerobic conditions are the predominant.

In a world with so many training zones and philosophies, at least we should agree in the “modern” principles of muscle bioenergetics during exercise.
We should make an effort to move on and get rid of 50+ year old inaccurate concepts like “anaerobic threshold” and “aerobic threshold” 🙏