My cousin in the UK is moving house tomorrow, six people in the "chain". One of them this morning just sent an email saying he's Β£20,000 short and asking everyone else to jointly make up the difference or the entire deal folds.
The debate over a blocked Peckham regeneration scheme has pitted YIMBYs against local Labour politicians and raised questions about London's affordable housing crisis.
Piece with @Smyth_Chris@JBSteins https://t.co/6U7XQETdcm
In some very real sense, Ozempic was invented in 1990. Pfizer ran the human trials and just never published them.
They showed it lowered blood glucose in diabetics, slowed gastric emptying, and killed hunger; the same 3 things that make Ozempic work today.
The joint venture agreement said internal data stayed internal, and that was that. Pfizer killed the program in 1991. The reasoning, as far as I can tell, was that nobody would ever want an injectable diabetes drug besides insulin.
So, the license went back to the hospital in Boston that held the patents.
Novo picked it up in 1992 and spent the next two decades building liraglutide, then semaglutide.
It's insane that data sat in a filing cabinet for 30+ years.
I only know this because Jeffrey Flier, one of the Harvard scientists in the room, finally wrote it up. He's in his late 70s and didn't want the history to die with him.
This makes you wonder what else is in those filing cabinets.
Ozempic could've existed 27 years ago.
Striking stat from @Smyth_Chris story on decline in primary school enrolment: Islington will see more than 1/5th of its primary pupils disappear by 2029-30.
Wrote about what happens to closing schools last summer https://t.co/dGI39qQAz2
Was very fortunate to be able to work on the latest series of the FT's investigative podcast, on the Catholic group Opus Dei, w/ @antoniacundy
The series looks at Opus Dei's expansion across the United States - including its think tanks and DC networks.
https://t.co/L0bZkkCYPK
Wrote about how the Renters Rights Act is reshaping the UK's rental sector: a spike in evictions in the run-up to the bill, the implications for small-time landlords (and potential corporate consolidation) + a new tribunal pathways for renters.
https://t.co/ZlqoarQIc0
Inside the Jeff Koons bubble with @milesellingham@JeffKoons, the man who holds the record for the highest price paid at auction for work by a living artist unveils a shiny new Venus in Athens β and answers questions about balloon animals, porn stars and dinner with Jeffrey Epstein
https://t.co/4AQFnq3kyT
βDune, a crypto data platform, found that 58% of user wallets on Polymarket were in the red. Among those who wagered money on Polymarket, the median loss was -$94.β
https://t.co/CIYo9pyV28
Clavicular reveals his current daily drug protocol
"Adderall 30mg a day dosed 10, 10 and 10. Last dose is variable depending on whether I'm streaming or want to go to bed early. Selegiline which is an MAO-B inhibitor, basically blocks your body from breaking down dopamine, that's a transdermal patch. Pregabalin to block excitatory neurotransmitters so I'm less anxious and can handle crowded spaces. And Baclofen which is a GABA-B agonist similar to the receptor alcohol hits since I'm quitting drinking."
Enhanced Games make a pivot into peptides off the back off an RFK Jr. appearance on the Joe Rogan podcast.
Part of a new race for peptide commercialisation.
Story with @Temple_West and @Mikepeeljourno
https://t.co/ZjA6wKKgnG
The fact that mortgage rates have remained high has really disguised the massive inflation-adjusted repricing in London property. The real-terms price of flats isn't that far above the post-financial crisis lows any more.
Journalists want to be there at the precipice of history. For my first outing as a senior writer for @ObserverUK , I realised that ambition. I went to Crufts. The worlds greatest dog show.
Just under 2 million people - a staggering figure - are currently in prison in the US. What's being proposed here is locking up roughly 1.5 million _more_ people in facilities. Many downsides - and not a particularly efficient way of spending government funds.