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Chinese Journal of Natural Medicines
@JournalCJNM
CJNM is devoted to communicating among pharmaceutical and medicinal plant scientists to advance research in natural medicines and traditional Chinese medicines.
Washington, DC
Joined October 2023
309 Following
450 Followers
929 Posts
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Complement C3 drives kidney inflammation and fibrosis.
This CJNM study demonstrates that SPX-derived peptide AAQFFNR inhibits complement C3 activation, protects renal function, and attenuates fibrosis in nephropathy models. Peptidomics + molecular docking + in vivo validation highlight insect-derived peptides as a promising therapeutic avenue.
📖Mechanistic insight for natural reno-protective therapy
🔗 Read on ScienceDirect：https://t.co/d4fAVA7BAS
#Nephropathy #MantidisOotheca #BioactivePeptides #ComplementC3 #CJNM
🚀 🎉📈We’re proud to share that Chinese Journal of Natural Medicines (CJNM) has reached a 2025 Impact Factor of 7.5 (🎉+53% compared to the previous year）
It is ranked 3rd out of 48 journals in the WoS category "INTEGRATIVE & COMPLEMENTARY MEDICINE" and 27th out of 356 journals in "PHARMACOLOGY & PHARMACY", both of which fall within the Q1 quartile. The journal received a total of 1,293 citations in 2025.
This milestone reflects the vibrant contributions of our authors, reviewers, editors and readers—thank you!
#ImpactFactor #CJNM
Full article: https://t.co/U4FtHoodrC
Seven new sesquiterpenoids (penicipenoids A−G) from marine sponge‑derived Penicillium sp. 5975 feature unprecedented skeletons. 🧪
Penicipenoid A has a rare tricyclo[4.4.11,602,7]hendecane core; D contains an unusual furan; F is a norsesquiterpene. In transgenic zebrafish, compounds 1‑3 show antioxidant, and 5 potent anti‑inflammatory activity.
Structural elucidation via HR‑MS, NMR, X‑ray, and ECD. 🌊🐟
#MarineNaturalProducts #Sesquiterpenoids #Antioxidant #AntiInflammatory
![JournalCJNM's tweet photo. Seven new sesquiterpenoids (penicipenoids A−G) from marine sponge‑derived Penicillium sp. 5975 feature unprecedented skeletons. 🧪
Penicipenoid A has a rare tricyclo[4.4.11,602,7]hendecane core; D contains an unusual furan; F is a norsesquiterpene. In transgenic zebrafish, compounds 1‑3 show antioxidant, and 5 potent anti‑inflammatory activity.
Structural elucidation via HR‑MS, NMR, X‑ray, and ECD. 🌊🐟
#MarineNaturalProducts #Sesquiterpenoids #Antioxidant #AntiInflammatory](https://pbs.twimg.com/media/HK7x4hea8AA1puC.jpg)
Liver failure can harm the brain – but milk thistle derivative silibinin meglumine may help. 🌿🧠
In a study, it lowered toxic ammonia, reduced inflammation, and protected brain cells by fixing damaged mitochondria and stopping excessive self‑destruction (mitophagy). It targets a key “stress brake” protein (UCP2). This natural compound offers hope for hepatic encephalopathy patients. 💚
#LiverHealth #BrainProtection #NaturalTherapeutics
Could a compound found in citrus peels be a new weapon against lung cancer? 🍊
🛡️ Researchers have discovered that Nobiletin, a natural molecule from citrus, works brilliantly alongside modern cancer drugs to stop the growth of non-small cell lung cancer. By mimicking the body’s natural "cell-death" signals, Nobiletin helps trigger a dual attack—inducing both apoptosis and autophagy—to clear away tumor cells more effectively. This powerful combination not only boosts treatment impact but also helps bypass common drug resistance.
Dive into the science of how nature’s own molecules are being harnessed to create smarter, stronger therapies for a healthier future! ✨🚀
#LungCancerAwareness #NaturalHealing #CancerFighter #MedicalBreakthrough #HealthyLiving
Uncover the synergistic potential of Nobiletin in non-small cell lung cancer (NSCLC) therapy! 🔬
This study identifies Nobiletin, a natural citrus flavonoid, as a novel BH3 mimetic that enhances the efficacy of the HDAC inhibitor vorinostat. By down-regulating anti-apoptotic proteins (BCL-2, MCL-1) and modulating the TRKC/PI3K/AKT/mTOR signaling axis, the combination treatment effectively induces both apoptosis and autophagy in NSCLC cells. These findings highlight Nobiletin’s role in overcoming tumor resistance and provide a mechanistic basis for developing dual-targeting strategies in lung cancer management.
A significant step forward in natural product-based oncology research! 🧬📉
#CancerResearch #Oncology #Autophagy #Apoptosis #NaturalProducts
Read more: https://t.co/UQEsgHjSBa
Can silibinin meglumine (SM) treat hepatic encephalopathy (HE)? 🧠⚡
In TAA-induced HE mice, SM lowers serum ammonia, improves liver enzymes (ALT/AST/TBil), and reduces TNF/IL-6. SM directly targets UCP2 (validated by docking, CETSA, DARTS, MST) and modulates UCP2/PINK1/Drp1/MFN2/LC3B axis, alleviating oxidative stress and excessive mitophagy. A UCP2 inhibitor partially reverses SM’s effects.
SM offers a dual hepato‑neuroprotective strategy via mitochondrial quality control. 🔬🌿
#HepaticEncephalopathy #SilibininMeglumine #UCP2 #Mitophagy
Access the full research here: https://t.co/a0irdctdRa
Could a common ornamental plant hold the secret to soothing Rheumatoid Arthritis? 🛡️🌿
Murraya exotica, known for its fragrant blooms, is showing remarkable promise in protecting joints from the damage caused by chronic arthritis. This latest research reveals that its natural extract can significantly reduce joint swelling, bone erosion, and painful inflammation by blocking key "inflammatory switches" in the body. By calming the immune system’s overreaction and reducing oxidative stress, this traditional botanical is being transformed into a potential new therapy for joint health.
Discover how the power of nature is being harnessed to help millions regain their mobility and comfort! ✨🦴
#JointHealth #ArthritisRelief #NaturalHealing #RheumatoidArthritis #HealthyJoints
Discover how the synergy of Network Pharmacology (NP) and Artificial Intelligence (AI) is transforming our understanding of Ganoderma spp.! 🍄
This review highlights the transition from traditional use to precision herbal medicine by integrating complex compound-target-pathway-disease networks with advanced predictive modeling. AI enhances target prioritization and the analysis of large-scale pharmacological data, offering innovative strategies to decode the multi-component, multi-target nature of these prized fungi.
By strengthening the scientific foundation of Ganoderma-based therapeutics, this integrative approach paves the way for rational formulation and global acceptance of natural medicine in the modern era. 🔬🤖
#Ganoderma #NetworkPharmacology #ArtificialIntelligence #PrecisionMedicine #TCM
Read the full article here: https://t.co/WKw8lgbpcm
Investigate the anti-arthritic potential of Murraya exotica L. (ME) in this groundbreaking study! 🌿
Characterized via UPLC, ME extract—rich in meranzin hydrate and murrayone—demonstrates significant therapeutic benefits in collagen-induced arthritis (CIA) models. By inhibiting synovial hyperplasia, bone erosion, and oxidative stress, ME effectively modulates the NF-κB and AP-1 signaling pathways. Molecular docking and CETSA/DARTS assays confirm strong interactions between ME-derived compounds and NF-κB p65, preventing nuclear translocation and suppressing inflammatory responses.
These findings provide the first evidence for ME as a promising natural candidate for Rheumatoid Arthritis (RA) management, offering a multi-target approach to autoimmune joint destruction. 🔬🦴
#RheumatoidArthritis #MurrayaExotica #NaturalProducts #AutoimmuneDisease #Inflammation
Cinnamon is more than just a spice—it's a potent multi-target phytotherapy for diabetes. 🧪
This comprehensive review aligns perfectly with our focus on the mechanistic and clinical validation of traditional natural medicines.
#DiabetesResearch #Phytotherapy #NaturalMedicine #CJNM
Cinnamon as a multitarget anti-diabetic phytotherapy: Phytochemical profiling, mechanistic interaction, & clinical trials
✅️ This paper provides a comprehensive review of recent advances in the use of cinnamon & its bioactive compounds for diabetes treatment. It examines multi-target mechanisms of action & translational clinical studies, while also exploring cinnamon's synergistic potential in combination therapies and its role in mitigating diabetic complications
Highlights:
▶️ The anti-diabetic components of cinnamon were summarized.
▶️ The anti-diabetic mechanism of cinnamon was summarized in detail.
▶️ Human trials of cinnamon for diabetes management since 2016 were summarized.
▶️ The prospect of cinnamon in treating diabetes was discussed.
https://t.co/eTjqNnpeNY @HealthyFellow @_INPST @_atanas_ @drfherediaz @DHPSP
Could a compound found in citrus peels be a new weapon against lung cancer? 🍊
🛡️ Researchers have discovered that Nobiletin, a natural molecule from citrus, works brilliantly alongside modern cancer drugs to stop the growth of non-small cell lung cancer. By mimicking the body’s natural "cell-death" signals, Nobiletin helps trigger a dual attack—inducing both apoptosis and autophagy—to clear away tumor cells more effectively. This powerful combination not only boosts treatment impact but also helps bypass common drug resistance.
Dive into the science of how nature’s own molecules are being harnessed to create smarter, stronger therapies for a healthier future! ✨🚀
#LungCancerAwareness #NaturalHealing #CancerFighter #MedicalBreakthrough #HealthyLiving
A profound look at chronic pain as a systemic interoceptive dysregulation. 🧠
At CJNM, we are actively exploring how natural bioactive compounds can target neuroinflammation and metabolic pathways to restore this vital balance.
#ChronicPain #Neuroscience #NaturalMedicine
Neuroinflammation, Metabolic Dysfunction, & Chronic Stress Converge on the Insular Cortex in Chronic Pain
✅️ The evidence reviewed suggests that chronic pain may be understood not only as a disorder of nociceptive persistence, but also as a disturbance in the brain’s capacity to accurately interpret and regulate internal bodily states
HIGHLIGHTS:
▶️ Anthropogenic and lifestyles factors drive insular dysfunction via allostatic load
▶️ The insula integrates salience across metabolic, immune, and stress signals
▶️ Insular dysfunction impairs interoceptive predictive processing
▶️ Chronic pain reflects disrupted interoceptive integration
https://t.co/EdVzidKeSl
@HealthyFellow @tatiann69922625
Conceptual model of interoceptive dysregulation in chronic pain.
Schematic overview of the proposed framework linking anthropogenic & lifestyle-related exposures w/chronic pain. These factors converge on chronic stress, metabolic dysfunction, & neuroinflammatory processes, which collectively influence the insular cortex as a central hub of interoceptive processing.
Alterations in insular function may disrupt the integration of internal bodily signals, leading to reduced interoceptive accuracy & increased hypervigilance. This imbalance may bias salience attribution, promoting pain as a dominant perceptual signal. Over time, these processes are embedded within a feedback loop involving cumulative physiological burden (allostatic load), contributing to the persistence of chronic pain
What happens when ancient herbal wisdom meets modern Artificial Intelligence? ✨
Ganoderma (Lingzhi), a cornerstone of traditional medicine, is getting a high-tech upgrade! Researchers are now using AI and network pharmacology to map out exactly how these "mushrooms of immortality" work at a molecular level. This cutting-edge approach helps identify key bioactive compounds and therapeutic pathways, making Ganoderma treatments more precise and effective than ever before.
From ancient rituals to future-ready precision medicine, join us as we explore how technology is illuminating the path to a new era of natural health! 🍄🚀
#Lingzhi #AIinMedicine #NaturalHealth #FutureOfMedicine #Ganoderma #SmartHealth #ScienceInnovation
Read the full article here: https://t.co/BHpgsBDrI1
Uncover the synergistic potential of Nobiletin in non-small cell lung cancer (NSCLC) therapy! 🔬
This study identifies Nobiletin, a natural citrus flavonoid, as a novel BH3 mimetic that enhances the efficacy of the HDAC inhibitor vorinostat. By down-regulating anti-apoptotic proteins (BCL-2, MCL-1) and modulating the TRKC/PI3K/AKT/mTOR signaling axis, the combination treatment effectively induces both apoptosis and autophagy in NSCLC cells. These findings highlight Nobiletin’s role in overcoming tumor resistance and provide a mechanistic basis for developing dual-targeting strategies in lung cancer management.
A significant step forward in natural product-based oncology research! 🧬📉
#CancerResearch #Oncology #Autophagy #Apoptosis #NaturalProducts
Dive into the vast pharmaceutical potential of the ocean with this in-depth review of marine bioactive peptides! 🌊
As research intensifies, these marine-derived products are emerging as critical candidates for drug development due to their structural diversity and unique biological activities. This review systematically explores advanced extraction techniques—moving beyond enzymatic hydrolysis to microbial fermentation and gastrointestinal simulation—while highlighting the role of high-throughput technologies and bioinformatics in identifying peptides with potent immunoregulatory, antioxidant, and antitumor effects.
Despite challenges in large-scale acquisition, the integration of advanced chromatography and computational biology is paving the way for addressing global health challenges with marine-derived treasure troves. 🔬
#MarineBiology #BioactivePeptides #DrugDiscovery #MarineDrugs #Biomedicine
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