Jonathan Weissman's Lab

Jonathan S. Weissman's lab at the @WhiteheadInst/@MIT. Account run by lab members.

[Daniel Lewinsohn @dlewinsohn11]

I'm also excited to share the first application of MeRN to study metabolic regulation in mouse embryos (including mutants)! Nick Dias of the Smith Lab led this work with me, in collaboration with the @jswlab. Now on bioRxiv! 🧵 1/
https://t.co/0cRjFykJSF

[Jonathan Weissman's Lab @JswLab]

@LukeKoblan @WilliamNColgan @YaleMed @nir_yosef1 @WeizmannScience @ZhuangLab @HarvardCCB @Stanford Thank you to @czi @hhmi_science @WhiteheadInst @NIH for supporting this work.

[Jonathan Weissman's Lab @JswLab]

Thrilled to share that our work reconstructing a cell fate map of the mouse embryo is out now in @CellCellPress! https://t.co/AnAlTivwNp

[Jonathan Weissman's Lab @JswLab]

🍾 Huge congratulations to @LukeKoblan @WilliamNColgan and many thanks to our wonderful collaborators Zachary Smith @YaleMed and MPIMG, @nir_yosef1 @WeizmannScience, @ZhuangLab @HarvardCCB, and Kyle Loh @Stanford

[Luke Koblan @LukeKoblan]

This has been an incredible, collaborative effort co-led with @WilliamNColgan in the @JswLab and with Zach Smith’s group at Yale and the @maxplanckpress and his amazing group members @CAbiologist , Jason Hou, and Minming Wang and our other wonderful collaborators.

[William Colgan @WilliamNColgan]

A fantastic collaboration with @LukeKoblan! Excited to see what the developmental biology community can learn from these data. Check out our CELLxLINEAGE explorer: https://t.co/4BFCFA1OCA

[Jonathan Weissman's Lab @JswLab]

A discovery of a novel resilience factor from a genome-scale ORF screen. Led by @Y_Ryan_Lu in the lab - five+ years in the making.

[Yuancheng Ryan Lu @Y_Ryan_Lu]

1/ Excited to share our new preprint from a joint collaboration between @JswLab + @Bruce_Ksander!

Aging is marked by a progressive loss of resilience to stress. Can we systematically search the human ORFome for genes that make vulnerable cells more resilient?

Performing such a genome-scale ORF screen led us to NKX2-5—a heart transcription factor we engineered to restore vision, and improve health in aged mice.

A breakdown🧵
🔗 https://t.co/WVIO7JOx3p

[Jonathan Weissman's Lab @JswLab]

You can apply at: https://t.co/qtjevLq0zO

[Jonathan Weissman's Lab @JswLab]

We’re hiring a Technical Assistant I/II in the Weissman Lab @WhiteheadInst to work on in vivo functional genomics with multimodal readouts.

Our technicians have had incredible success going on to PhD & MD/PhD programs. Apply or send great candidates our way!

[Jonathan Weissman's Lab @JswLab]

Excited to share our new preprint led by
@YiChenNeumann with incredible collaborators @labs_mann, @BenGewurz, @StephenE92884, and @hopfnerlab
to characterize the function of thousands of viral microproteins from human-infecting viruses! https://t.co/iRXXkWES0N

[Yi Hua Chen-Neumann @YiChenNeumann]

Excited to share my PhD work, now on @bioRxiv! 🎓🦠Viruses are packed with small ORFs with unknown function. At @JswLab w/ collaborators, we built a pan-viral microprotein atlas that uncovered the oncogenic activity of BNLF2b, an EBV gene linked to cancer.
https://t.co/KYzeoMBvb5

[Yi Hua Chen-Neumann @YiChenNeumann]

Excited to share my PhD work, now on @bioRxiv! 🎓🦠Viruses are packed with small ORFs with unknown function. At @JswLab w/ collaborators, we built a pan-viral microprotein atlas that uncovered the oncogenic activity of BNLF2b, an EBV gene linked to cancer.
https://t.co/KYzeoMBvb5

[Jonathan Weissman's Lab @JswLab]

Impressive work from @JShendure & co. reconstructing an E13.5 lineage tree with DNA Typewriter. A great complement to our PEtracer lineage atlas spanning E7.5-E10.0 (https://t.co/HwuJc2y7ha). Excited to see what an integrated analysis of these datasets reveals!

[Jay Shendure @JShendure]

Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote
1/n

[Jonathan Weissman's Lab @JswLab]

Exciting work led by @AniaPuszynska !

[Ania Puszynska @AniaPuszynska]

Excited to see our work now published https://t.co/oa2wneGAIX!
Lysosomal dysfunction has long been considered a hallmark of aging, but we still know remarkably little about what actually changes inside lysosomes as organisms grow old. Using rapid lysosome isolation and metabolomics, we built the first atlas of lysosomal aging across tissues.

[Manuel Leonetti @LeonettiManuel]

📣 new preprint multimodal atlas. Imaging + scRNA, 57M cells. 🧬🔬

Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std?

The answer surprised us 🧵

https://t.co/RG0PZ1KTHW

[ZhuangLab @ZhuangLab]

What is the global structure of cell-state space—and how do perturbations drive transitions within it?

Excited to share our new preprint (https://t.co/ZTlAY4eaJf), a work in collaboration with @JswLab.

[Luke Koblan @LukeKoblan]

A few years in the making in the @JswLab with @WilliamNColgan, Zack Smith, and the rest of our fantastic team: Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis. Excited to hear everyone's thoughts!