🧬How can enhancers achieve tissue-specific activity? We use MPRAs of synthetic enhancers to derive interpretable rules on TFBS arrangement🚦and discover that negative synergies drive specificity in hematopoiesis. Shoutout to @robert_froemel &
@larsplus for leading this work🦹
PAPER ALERT! Excited to share my PhD work in the lab of @larsplus @CRGenomica. We screened minimalistic synthetic enhancers throughout myeloid differentiation. We uncovered widespread dual activator-repressor functions for individual TFs and TF pairs https://t.co/D3XlH99RH7 (1/n)
🩸VELTEN LAB @larsplus
🔬 We're exploring gene regulation and synthetic enhancers in hematopoiesis using high-throughput genetic screens.
Seeking a motivated student interested in gene regulation, data analysis, and the hematopoietic system. Programming experience in R/Python preferred. Excited to learn? Contact PI and Julia Ruehle to apply 👉🏾https://t.co/kGK586yJ2f
#Hematopoiesis #GeneRegulation
Shoutout to my fantastic PhD colleague @robert_froemel for his work on screening thousands of synthetic enhancers in differentiating primary cells. Glad to be part of it 😊
Extremely happy I was able to be part of the Biological Data Science Summer School in Uzhorod, Ukraine, to help out as a teaching assistant.
With speakers and teachers from Europe and US, and over 60 fantastic students from all over the country.
Excited to share our latest manuscript! We investigated cellular hierarchies in AML using clonally-resolved single-cell multi-omics. We found some similarities to healthy differentiation but observed differences particularly at the stem cell level https://t.co/m535JnJMyZ (1/n)