Kepa Berraondo

[Kepa Berraondo @KBerraondo]

@GroupLaakkonen @GustavoEgeaGuri Such long-term expression might be a problem if adverse effects arise due to the sustained blockade of TGF beta. An alternative is the use of mRNA-based strategies. In this case, repeated administration of the mRNA is required.

[Kepa Berraondo @KBerraondo]

@GroupLaakkonen @GustavoEgeaGuri A single injection of these drugs can induce therapeutic levels of the transgen-encoded protein for years.

[Kepa Berraondo @KBerraondo]

@GroupLaakkonen @GustavoEgeaGuri Circulating in high-density lipoproteins is important because they have long half-life and interact with all tissues that express SR-B1, including aorta.

[Kepa Berraondo @KBerraondo]

@GroupLaakkonen @GustavoEgeaGuri Another estrategy was required to attain the therapeutic effect in the aorta: the anti-TGF-beta peptide is produced as a fusion protein with apolipoprotein A-I. Thus, our active moiety circulates in high density lipoproteins.

[Kepa Berraondo @KBerraondo]

@GustavoEgeaGuri @GroupLaakkonen Interestingly, a reduction in the large elastic fiber ruptures were detected in treated animal in the advanced setting. Unfortunately, this effect did not translate into a functional improvement.