10Y at 4.52%, 30Y over 5% ๐ Bonds crashing, gold & silver taking a hitโฆ but honestly, this looks like a prime setup. Iโm keeping some $XAU/$XAG ready, if yields spike more, metals could pop
Bond yields broke out just as I predicted they would. Today's selloff in gold, and especially the $6.70 plunge in silver, is a great buying opportunity, as investors who expected bond yields to fall have no idea what higher yields portend for inflation and precious metals.
Gold down 2.2% this week and I keep coming back to the same thought.
Silver especially sits at a rare intersection: monetary asset, industrial input, and a nascent role in the clean energy buildout. The demand stack is more layered than it looks.
@derrick_dao@WhaleInsider Its also short term influence and worries about India increased tariffs on gold and silver. Still very bullish long term both
Silver at $83 is still 2x the 2024 average. A 5% drop on this tape is COMEX short-side unwind and CTA position trimming โ not a change in physical. Solar + EV demand runs >25% above the pre-2022 baseline. ~70% of supply comes as byproduct of copper, zinc and gold mines, so primary doesn't respond to silver prices.
INDIA'S GEMS & JEWELLERY EXPORTS FELL 9.07% YOY TO $2.45B IN APR 2026, PRESSURED BY WEAK DEMAND AND PRICE VOLATILITY. DIAMOND AND PLAIN GOLD SHIPMENTS SLUMPED, WHILE SILVER AND PLATINUM JEWELLERY ROSE.
@BIOTECHSCANNER I'm not like most investors I look at the money I put into biotech specifically cancer research biotech as if I was tidying in a church and I expect expect nothing back. This is purely the reason why I do it so someone beats cancer and this is the greatest reason for me to
$IOVA - FDA DESIGNATIONS ๐
Melanoma (C-144-01)
RMAT, Fast Track, Orphan Drug, Priority Review, Accelerated approval in the US.
Lung cancer (IOV-LUN-202)
Fast Track Designation
Available for registration application.
Cervical cancer (C-145-04)
Breakthrough Therapy Designation.
@BiotechFQ clean CRL plus a 50% rep expansion before launch tells you everything about how aqst is reading the timeline. they are building for ship, not stall.
$AQST Q1 results
The CRL did not identify any chemistry, manufacturing, or controls (CMC) deficiencies, and clinical results supporting comparability to auto-injectors were not questioned.
# sales representatives - increase of 50% to 75. https://t.co/KDI3FIMKLy
$IOVA - Absolutely love that they gave a tour of iCTC to these patients who were practically cured from their cancer. Mostly of these patients were on their way to hospice.
https://t.co/prEyrbM8Zt
@Finsee_main 66% revenue growth (despite the 1 time royalty from $zvra formerly kempharm). still great news and speaks to their historical capability to execute. make it make sense for the bears.
$AQST Q1 2026 earnings: Revenues Surge as Aquestive Buys Time for Anaphylm
Aquestive delivered a remarkably clean quarter while navigating the delay of its flagship Anaphylm product. Revenue skyrocketed 66% year-over-year to $14.4 million, driven by a massive jump in royalty payments. Crucially, the company slashed its net loss by 65% to $8.1 million. With a new $150 million debt facility securing its runway, Aquestive is preparing to increase its planned sales force by 50% and target a Q3 2026 NDA resubmission. The fundamental story remains stable: execute the FDA requests and prepare the balance sheet for a transformational launch.
Full article with charts - link in bio
๐ ๐๐ฎ๐ฅ๐ฅ ๐๐๐ฌ๐
โข ๐๐ฅ๐๐๐ซ ๐๐๐ ๐ฎ๐ฅ๐๐ญ๐จ๐ซ๐ฒ ๐๐๐ญ๐ก โ The FDA Type A meeting is complete, aligning on human factors and PK study designs without any new CMC or clinical comparability hurdles. The Q3 2026 resubmission target is locked in.
โข ๐๐จ๐ฒ๐๐ฅ๐ญ๐ฒ ๐๐ง๐ ๐ข๐ง๐ ๐ ๐ข๐ซ๐ข๐ง๐ โ License and royalty revenues exploded from $0.8M to $5.4M. This high-margin cash flow acts as a powerful bridge while Anaphylm waits for approval.
๐ป ๐๐๐๐ซ ๐๐๐ฌ๐
โข ๐๐ฑ๐ฉ๐๐ง๐๐๐ ๐๐๐ฎ๐ง๐๐ก ๐๐ฎ๐ซ๐ง โ Management increased the planned sales force from 50 to 75 reps. If FDA review stretches into 2027, this bloated cost structure will torch the newly acquired cash runway.
โข ๐๐ฑ๐๐๐ฎ๐ญ๐ข๐จ๐ง ๐๐ข๐ ๐ก๐ญ๐ซ๐จ๐ฉ๐ โ Two clinical studies must be completed flawlessly and rapidly to meet the Q3 2026 resubmission timeline. Any misstep pushes revenue generation out indefinitely.
โ๏ธ ๐๐๐ซ๐๐ข๐๐ญ: ๐ข
Bullish. Management is executing exactly what they promised after the CRL setback: securing cheap debt, shrinking the baseline cash burn, and advancing the FDA dialogue. The core asset remains highly valuable.
๐๐๐ฒ ๐๐ก๐๐ฆ๐๐ฌ
๐ข๐ข ๐๐๐๐๐ฅ๐๐ซ๐๐ญ๐ข๐ง๐ ๐๐ข๐๐๐ง๐ฌ๐ ๐๐ง๐ ๐๐จ๐ฒ๐๐ฅ๐ญ๐ฒ ๐๐๐ฏ๐๐ง๐ฎ๐ [NEW]
High-margin revenue is accelerating rapidly. License and royalty revenue surged to $5.4 million from $0.8 million a year ago, primarily driven by Zevra. This transforms the income statement, dramatically lowering the cash burn right when the company needs to fund new Anaphylm clinical trials.
๐ข ๐๐๐ฌ๐ ๐๐๐ง๐ฎ๐๐๐๐ญ๐ฎ๐ซ๐ข๐ง๐ ๐๐จ๐ฅ๐ฎ๐ฆ๐ ๐๐๐๐จ๐ฏ๐๐ซ๐ฒ
The legacy CDMO business is stable to accelerating. Manufacture and supply revenue rose 22% YoY to $8.8 million, driven by an increase in total doses shipped (33 million vs 27 million in Q1 2025). Strength in Suboxone and other partnerships ensures the lights stay on without eating into launch capital.
๐ข ๐๐๐ซ๐๐ง๐๐๐๐ซ๐ฌ๐ ๐๐ง๐ง๐จ๐ฏ๐๐ญ๐ข๐จ๐ง: ๐๐๐๐-๐๐๐ ๐๐ข๐จ๐ฆ๐๐ซ๐ค๐๐ซ ๐๐ข๐ฌ๐๐จ๐ฏ๐๐ซ๐ฒ [NEW]
Aquestive is pushing the AdrenaVerse platform forward. The Phase 1 trial for the AQST-108 topical gel found no systemic absorption issues and successfully identified a biomarker signal suppressing the TSLP cytokine (involving JAK1/JAK2 pathways). This specific innovation opens the door to massive dermatological markets like atopic dermatitis.
๐ด ๐๐๐ฅ๐๐ฌ ๐ ๐จ๐ซ๐๐ ๐๐ฑ๐ฉ๐๐ง๐ฌ๐ข๐จ๐ง ๐๐จ๐ง๐ญ๐ซ๐๐๐ข๐๐ญ๐ฌ ๐๐๐ฌ๐ก ๐๐๐ซ๐ซ๐๐ญ๐ข๐ฏ๐ [NEW]
Management highlights their new $150M Oaktree debt and 'well-capitalized' status for launch. However, in the same breath, they announced a 50% increase in the planned Anaphylm field force (from 50 to 75 sales reps). Pushing fixed commercial costs higher while the drug's approval is delayed until at least late 2026/early 2027 creates a significant contradiction that threatens the cash runway if revenues don't materialize instantly upon launch.
โช ๐๐๐ ๐ฎ๐ฅ๐๐ญ๐จ๐ซ๐ฒ ๐๐ฑ๐๐๐ฎ๐ญ๐ข๐จ๐ง ๐๐ข๐ฌ๐ค ๐๐๐ฆ๐๐ข๐ง๐ฌ ๐๐ข๐ ๐ก
The path forward requires new human factors validation and a new PK study. While the Type A FDA meeting provided clarity, any patient dropouts, logistical delays, or slightly off-target PK data will shatter the Q3 2026 resubmission timeline. The risk profile is stable, but absolute execution is required.
โช ๐๐ฎ๐๐จ๐ฑ๐จ๐ง๐ ๐๐ฎ๐ง๐ฌ๐๐ญ ๐๐ฅ๐ฐ๐๐ฒ๐ฌ ๐๐จ๐จ๐ฆ๐ข๐ง๐
While Q1 saw a bump in Suboxone revenues, the long-term trend for this legacy asset is a gradual, terminal decline. Aquestive must continue outrunning this attrition with newer products like Ondif, Sympazan, and Emylif.
๐ข ๐๐ฆ๐ฆ๐ฎ๐ง๐ข๐ญ๐ฒ ๐ญ๐จ ๐๐๐๐ซ๐จ ๐๐๐ซ๐ข๐๐ ๐๐ก๐จ๐๐ค๐ฌ
In a volatile geopolitical environment, Aquestive confirmed its U. S.-domiciled intellectual property and U. S.-based manufacturing leave its supply chain completely unaffected by proposed and implemented government tariffs. This provides exceptional margin visibility compared to peers heavily reliant on Asian or European API sourcing.
๐๐ญ๐ก๐๐ซ ๐๐๐๐ฌ
๐๐ฉ๐๐ซ๐๐ญ๐ข๐ง๐ ๐๐ฑ๐ฉ๐๐ง๐ฌ๐๐ฌ (๐๐&๐): $11.0 million
Decelerating aggressively. SG&A dropped 42% from $19.1 million in 25Q1. This was largely due to the non-repeat of a $4.3M Anaphylm PDUFA fee, alongside $3.4M in lower legal fees and $2.0M less in commercial spending. The company is successfully clamping down on costs during the regulatory delay.
๐๐๐ฌ๐ก ๐๐ง๐ ๐๐ช๐ฎ๐ข๐ฏ๐๐ฅ๐๐ง๐ญ๐ฌ: $110.7 million
Stable position. Down slightly from $121.1 million at year-end 2025, but robust enough to weather the Anaphylm delay. The new $150M Oaktree debt facility saves $45M in near-term principal payments, pushing maturities out to 2031 and unlocking optionality.
๐๐ฎ๐ข๐๐๐ง๐๐
๐ ๐๐๐ ๐๐จ๐ญ๐๐ฅ ๐๐๐ฏ๐๐ง๐ฎ๐: $46 - $50 million
Stable. Guidance implies an accelerating run rate to hit the $48M midpoint. Q1 delivered $14.4M, meaning the company is currently pacing ahead of its own full-year implied quarterly average ($12M). Achievement is highly likely.
๐ ๐๐๐ ๐๐จ๐ง-๐๐๐๐ ๐๐๐ฃ๐ฎ๐ฌ๐ญ๐๐ ๐๐๐๐๐๐ ๐๐จ๐ฌ๐ฌ: $30 - $35 million
Stable. The maintained guidance midpoint of -$32.5M indicates management expects spending to ramp back up in the second half of the year to support the new Anaphylm clinical trials and expanded sales force preparations.
๐๐๐ฒ ๐๐ฎ๐๐ฌ๐ญ๐ข๐จ๐ง๐ฌ
๐๐๐ฅ๐๐ฌ ๐ ๐จ๐ซ๐๐ ๐๐๐
What specific market data drove the decision to increase the Anaphylm launch field force by 50% from 50 to 75 reps, and how does this alter your break-even timeline post-approval?
๐๐๐๐-๐๐๐ ๐๐ญ๐ซ๐๐ญ๐๐ ๐ข๐ ๐๐ข๐ฏ๐จ๐ญ
The AQST-108 update mentioned utilizing an atopic dermatitis study design. Does this represent a permanent shift away from alopecia areata as the lead indication, or are you pursuing both in parallel?
๐๐๐๐๐ฅ๐๐ซ๐๐ญ๐๐ ๐๐๐ฏ๐ข๐๐ฐ ๐๐จ๐ง๐๐ข๐๐๐ง๐๐
You plan to request an accelerated FDA review upon Anaphylm's resubmission in Q3. Given the historical strictness of this division, what specific precedents give you confidence this request might be granted?
$IOVA ASCO Annual Meeting (May 29 - June 2, 2026): This is the world's largest and most important congress for cancer research, where Iovance traditionally shares updates on its pipeline, including next-generation treatments such as IOV-4001.
$iova Every commercial infusion not OOS (R&D expense) or patient drop off (COS expense) hugely benefits the bottom line.
Said differently, the reductions in R&D are likely from better manufacturing and patient selection, not just refinement in trial and general R&D expenditure.
$AQST at current valuations we are getting for FREE: libervant, aqst-108, and if you studied the stock at all, anaphylm crushing the prescriptions. This stock still priced liked a pre commercial risk on venture