Kyle S Smith

Senior bioinformatic scientist at St. Jude Children's Research Hospital

[Kyle S Smith @KSSKyleSmith]

Many pediatric cancers are fundamentally developmental disorders. With our recent publication we have discovered the origins of medulloblastoma within the developing cerebellum. #teamscience #stjude
https://t.co/xf7feR0iD9

[CENOS St Jude @SJCENOS]

The Northcott lab conducted an extensive re-analysis of a single-cell transcriptional atlas of human cerebellar development originally published in 2022. During this process, we identified significant concerns related to data integrity and interpretation,

[Kyle S Smith @KSSKyleSmith]

@SciPyTip Isn't scipy.sparse.sparsetools deprecated?

[St. Jude Research @StJudeResearch]

Where does medulloblastoma come from? St. Jude scientists have helped figure it out. https://t.co/TcYYjktlgO
@drpaulnorthcott @nature #childhoodcancer #braintumor #CCAM #CancerResearch

[Kyle S Smith @KSSKyleSmith]

These findings set the foundation to better model and hopefully treat these tumors going forward. So proud to be a part of this all-star team with Laure Bihannic and @B_gudenas headed by @drpaulnorthcott and @neurodevKathy

[Kyle S Smith @KSSKyleSmith]

Many pediatric cancers are fundamentally developmental disorders. With our recent publication we have discovered the origins of medulloblastoma within the developing cerebellum. #teamscience #stjude
https://t.co/xf7feR0iD9

[Kyle S Smith @KSSKyleSmith]

These cells are located in a region of the cerebellum known as the Rhombic Lip, which give rise to the glutamatergic neurons. Overlapping MRIs of many Group 3 and 4 medulloblastoma tumors revealed that these tumors are fully encapsulated within this region.

[St. Jude Research @StJudeResearch]

St. Jude scientists have discovered the developmental origins for Group 3 and Group 4 medulloblastoma which may help improve research models and potential therapeutics. https://t.co/YxW7LFyQ8k @nature @drpaulnorthcott #childhoodcancer #CCAM

[Brian Gudenas @B_gudenas]

1/5 Our new paper resolving the developmental origins of Group-3 Medulloblastoma is out @Nature

Previously the cellular origins of Group3-MB were unknown despite multiple cross-species efforts comparing MB tumors to mouse cerebellar single-cell atlases.
https://t.co/7RpPowpO7d

[Memphis Police Dept @MEM_PoliceDept]

UPDATE: the suspect is still at large. If you do not have to be out, stay indoors until this is resolved.

[SPIN | Society of Pediatric Neuroimaging @spinacademics]

As we bid a final goodbye today we ll fondly remember Prof. Zoltan Patay for his immeasurable contributions to #pedineurorad
@drmankad
@StJudeResearch @The_ASPNR @ESNRad @zguroztekin @drpaulnorthcott @TYPoussaintMD @draash @hakimaalhashimi @LorenzoPinelli @nihaal08 @MirskyDavid

[Kyle S Smith @KSSKyleSmith]

@fabian_theis Unipolar Brush Cells

[Kyle S Smith @KSSKyleSmith]

@lab_ogden @cshperspectives For software developers it is common to have a small rubber duck to talk to when debugging a program. Sounds like this might work well for complaining about reviewers as well

[Kyle S Smith @KSSKyleSmith]

@CraigHorbinski @NeurosurgeryNM @Lurieneurosurg @BrainTumorInst @NU_Pathology @neuropathology @NeuroOnc @TheUSCAP Medulloblastoma, (Group 4, subtype 8...just playing the odds on this one)

[Mike Dyer Lab @mikedyerlab]

Excited to share our latest pre-print building a single-nucleus atlas of pediatric rhabdomyosarcoma. We report heterogeneity within 18 patient tumors, and 18 xenografts from those same patient tissues, and show treatment selects for mesoderm-like cells #sarcoma @StJudeResearch

[Kyle S Smith @KSSKyleSmith]

https://t.co/Un2cHZeBtl

Excited to have this one out, and to be part of the great clinical work being done at St. Jude.

[Kyle S Smith @KSSKyleSmith]

https://t.co/uNwjGenjxE

[Kyle S Smith @KSSKyleSmith]

Its going to be a crazy night! Rocking some scrabble, maybe a movie, bed by 11 @erikdauster #gangster

[Kyle S Smith @KSSKyleSmith]

@erikdauster just put blanket away #StorageOttomanFTW