Kenn Samala

Internal Medicine-Medical Oncology. @pghoncology 🇵🇭 Thoracic Oncology Fellowship at Cross Cancer Institute. @crosscancer50 🇨🇦

@PSO1964 Vice-President 2025

[Kenn Samala @KSamalaMD]

✅️Potential Impact:

• faster TAT
• avoid a portion of rapid tests
• inc tissue availability fot NGS
• dec need for re biopsies
Ultimately leads to ➡️ improve cancer care

#ESMOAI25

[Kenn Samala @KSamalaMD]

How can we use AI to develop precision biomarkers by Gabriele Campanella

• Computational biomarker : less exhaustive (tissue) and shorter turn around time ⏩️ an ideal test indeed

#ESMOAI25

[Kenn Samala @KSamalaMD]

• role of AI in drug development is huge ➡️ high potential esp in different phases of clinical trial implementation (but might still be far to date)

"The future is in science of science"

@marinagarassino

#ESMOAI25

[Kenn Samala @KSamalaMD]

Role of AI in predicting drug activity by Marina Garassino

✅️ 80-90% Phase I success rates for AI designed drugs

#ESMOAI25

[Kenn Samala @KSamalaMD]

•Clinical trials are moving so fast, but knowledge cannot keep up

• another challenge : less no. Of patients eligible for targeted therapy trials

#ESMOAI25

[Kenn Samala @KSamalaMD]

AI and Medical Education Summary
✅️ AI tutors offer opportunities and personalize learning
✅️ #GenAI can inc efficiency in preparing teaching materials
✅️ newer models are more trustworthy but critical review is stil a MUST
#ESMOAI25

[Kenn Samala @KSamalaMD]

Use of generative AI for teaching: How are we educationg doctors of the future? By Ramona Woitek

Utility of AI in medical education:
• generation of clinical vignettes ➡️ but it is not perfect, still need to check for errors (spelling, etc)
#ESMOAI25

[Kenn Samala @KSamalaMD]

✔️In summary
AI literacy roadmap for Oncologists

Start with awarenes and foundational knowledge. Thankful to @myESMO for this inaugural conference 🧬🤖

#ESMOAI25

[Kenn Samala @KSamalaMD]

AI literacy for Oncologists by Anita Grigoriadis

Initial concerns of clinicians re: AI
• trust issues that include privacy concerns and AI being a "black box"

#ESMOAI25

[Kenn Samala @KSamalaMD]

Goal: convert black box to "glass box" ➡️ unmasking the uncertainties of AI for clinicians
#ESMOAI25

[Kenn Samala @KSamalaMD]

In summary:

What doctors should know about AI:

• apps & agents
• data and AI platform
• infrastructure

#ESMOAI25

[Kenn Samala @KSamalaMD]

What medical doctors should know about AI by Joost Huiskens

Challenge: more than 95% of health data is unstructured multimodal data

Microsoft is now working of tapping multiple agents in AI

Ex #MedImageParse

#ESMOAI25

[Kenn Samala @KSamalaMD]

Clear indication in automization of molecular tumor boards ➡️ further democratization of health care
#ESMOAI25

[Kenn Samala @KSamalaMD]

Conclusion:
• absence of DeepGrade high clusters constitutes an independent prognostic marker ➡️ identifying low-risk patients
• study highlights that spatial distribution of AI-markers requires stronger attention (prospective studies underway)
#ESMOAI25

[Kenn Samala @KSamalaMD]

Identification of a very low risk subgroup in breast cancer using a combination of spatial representation and AI-derived prognostic markers by Constance Boissin

#ESMOAI25

[Kenn Samala @KSamalaMD]

• tumor heterogeneity is known to be involved in increased proliferation of the tumors
• intermediate risk pts: ER+/HER2- (training set)- 12 year survival:
❗️ high risk patients: 93%
✅️ low risk patients: 97.2% (p <0.001)

#ESMOAI25

[Kenn Samala @KSamalaMD]

In conclusion
- little experience so far in oncology beyond image-based AI
- AI has the potential to facilitate and amplify human interactions
- help & guide patients and communicate on recommendations
- follow the recently published ELCAP guidelines

#ESMOAI25

[Kenn Samala @KSamalaMD]

How to use AI to balance patient and physician perspectives by Suzette Delaloge

#ESMOAI25

[Kenn Samala @KSamalaMD]

❗️The downside of AI in HCP-Patient Interactions

- shift attention away from the patient
- undermines clinical intuition and trust
- create a 'data power imbalance'
- could accelerate burnout instead of relieving it
- erodes moral dimension of medicine

#ESMOAI25