Kylie Lange

Statistician working in nutrition and diabetes clinical research; PhD student researching partially clustered trials

[Kylie Lange @K_Lange_]

📢Publication Alert! A new paper from my PhD is now online at Statistics in Medicine, sharing a simulation study on the performance of mixed effects models and GEEs for partially clustered trials. With @LisaYelland, Tom Sullivan & @JessKasza
https://t.co/GUHWeIdhnF
Summary🧵1/5

[Colin Begg @ColinBBegg]

Kylie Lange and colleagues outline a sample size calculator for clinical trials in which some participants are independent and others are clustered, such as multiple births. @K_Lange_ @UniofAdelaide @sahmriAU @austrim_cre @SCTorg

[Kylie Lange @K_Lange_]

@austrim_cre @LisaYelland My gratitude to @austrim_cre for the scholarship support and for providing such a valuable network with which to share and improve my ideas.

[SAHMRI @sahmriAU]

Help SAHMRI create healthier futures by applying to join our team!

Current vacancies:
🔢 Statistician
💻 Lead, Business Transformation
📊 Bioinformatician

Learn more ➡ https://t.co/FRbwhzPX30

[Kylie Lange @K_Lange_]

@DogICUma In addition to Shiny CRT already mentioned (which covers various clustered designs) there is also this one specific to cluster randomised designs and includes binary outcomes: https://t.co/t50gbdI8XN

[Kylie Lange @K_Lange_]

Some great work from @KristyRobledo looking at how multiple births are accounted for in neonatal trials (spoiler: not well!) - partial clustering in action!

[Kristy Robledo @KristyRobledo]

We should do better in accounting for multiple births in neonatal randomised trials: a methodological systematic review #newpaper @TrialsCentre
https://t.co/hhO6pCwjc1

[Kylie Lange @K_Lange_]

But not always! Mixed models and exchangeable GEEs did have some problems for some randomisation methods when the ICC was high. Check out the paper for what to consider when designing and analysing these trials! (5/5)
https://t.co/GUHWeIdhnF
@austrim_cre @sahmriAU @UniofAdelaide

[Kylie Lange @K_Lange_]

📢Publication Alert! A new paper from my PhD is now online at Statistics in Medicine, sharing a simulation study on the performance of mixed effects models and GEEs for partially clustered trials. With @LisaYelland, Tom Sullivan & @JessKasza
https://t.co/GUHWeIdhnF
Summary🧵1/5

[Kylie Lange @K_Lange_]

to compare the performance of GEEs and mixed models in estimating the treatment effect on a continuous outcome. We found that the power formulas for exchangeable GEEs are approximately accurate for mixed effects models. And in many settings, both methods perform well. (4/5)

[AusTriM @austrim_cre]

#Biostatistics #PhD opportunity in cluster trials @Monash_SPHPM with @JessKasza

📗📗📘📘
📘📗📗📘
📕📘📗📗
https://t.co/Zj8HYbaWmu

[Kylie Lange @K_Lange_]

@LSChapple @ICS_updates @__EVSmith @msummo2 Love the enthusiasm! 😁👏

[A/Prof Lee-anne Chapple @LSChapple]

The excitement of poster presentation at #SOA24 @ICS_updates 😂☺️

Great work, led by @__EVSmith along with @msummo2 @K_Lange_

[Kylie Lange @K_Lange_]

Just over one week to go, but there's still time to register! #ATMC23

[AusTriM @austrim_cre]

DAY 2

[Kylie Lange @K_Lange_]

This program looks fantastic - join us!

[AusTriM @austrim_cre]

The full program for the Australian Trials Methodology Conference 2023 is now online.

Check out some of our invited speakers

DAY 1

Full details:
https://t.co/8ER2FEsTp7

Tickets still available - attend in person or online!

[Kylie Lange @K_Lange_]

@Prof_KL_Jones @CRENutrition @AdelaideSPH Thanks Karen 🙂

[Kylie Lange @K_Lange_]

@CRENutrition @AdelaideSPH Thanks for the support!🙂

[AusTriM @austrim_cre]

We're getting pretty excited to see all our invited speakers - just over a month to go!

Contributed sessions will be announced shortly.

Have you got your tickets yet? 🎫 Join us in Melbourne or online!

https://t.co/LLPaduNkhd

[Kylie Lange @K_Lange_]

Many thanks to @austrim_cre for the travel support, and supervisors @LisaYelland,Tom Sullivan and @JessKasza.

[Kylie Lange @K_Lange_]

A late update, but I had a great time at #ISCB44 #ISCB2023 last week in Milan. I was able to share some my PhD research with a poster presentation and catch other @austrim_cre presentations from Ehsan Rezaei and Kelsey Grantham. I've come home with a head full of new ideas!