Kadence Bio

Developing innovative therapeutics that address critical unmet needs in sexual and mental health.

[Kadence Bio @KadenceBio]

Our CMO Dr. Gruss won best abstract in Male Sexual Function at the 2026 World Meeting on Sexual Medicine 🏆

Congrats Hans-Juergen and the team for the successful debut of our Phase 1 results!

#SexualMedicine #MensHealth #KadenceBio

[Kadence Bio @KadenceBio]

🌱 Nature has been running the world’s longest drug discovery program.

In this @Telegraph article, our CEO shares why building on what nature already offers can be a powerful starting point for modern drug development.

Read the article by @SimeonTegel 👇
https://t.co/4nwDOdqSHK

[Kadence Bio @KadenceBio]

🚀 Phase 2a is full steam ahead!
We’ve enrolled the first participant in our Phase 2a #clinicaltrial evaluating KH-001 for #prematureejaculation. A major milestone made possible by our team, partners, and the individuals who take part in this research.
#KadenceBio #SexualHealth

[Ayuh Ventures @AyuhVentures]

Most know how unsexy problems ruin lives quietly. Like, premature ejaculation is huge, under treated, and systemically downplayed. No FDA approved meds today, none. So we backed John Boghossian & his team at @KadenceBio a few years ago because fixing real life problems beats everything else.

Let’s talk about a category everyone giggles about, quietly googles in incognito, and then pretends doesn’t exist at the doctor’s office🤦🏼‍♂️. Premature ejaculation, yup. The punchline that isn’t funny anymore when it’s your relationship, your anxiety, your partner’s frustration. This isn’t niche at all, current estimates range from “at least 1 in 20 men” to “a big chunk of men depending on medical definition,” and Kadence’s own analysis pegs the global affected population at 100M+ men, plus their partners. That’s not a meme, far from it. That’s a market unfortunately and a public health problem hiding, growing in plain sight.

Here’s the crazy part, there is still no FDA approved medication for premature ejaculation in the U.S. Read that again. Doctors reach for off label SSRIs, tricyclics, topical numbing sprays, workarounds with awful side effects, and zero on label clarity. Dapoxetine, built specifically for PE, is approved abroad but not in the U.S. That regulatory vacuum is a big reason the problem still lingers.

The system we live in also downplays it because stigma is cheap and silence costs nothing. Men often don’t bring it up; physicians often don’t ask; and partners shoulder the fallout. The research is blunt, PE is linked to anxiety, depression, lower or no self esteem, and relationship strain and partners who have PE report lower relationship and sexual satisfaction. So the quiet suffering scales.

Now layer in the incentives. Regulators (rightly) want high safety bars for a non life threatening condition. Big companies prefer categories with cleaner narratives and historic wins. ED got Viagra and a spicy ending. PE got off label hacks and awkward silence, facts. Dapoxetine helped, but real world drop offs and side effects kept it from becoming the poster child. The result? ‘Unsexy’ aka, investors ducked the homework narrative.

At Ayuh, we fund reality. A few years ago we backed John & his team at Kadence Bio because they’re building the first credible on demand pathway to an FDA approved PE therapy. Their lead, KH-001, completed Phase I; Phase II is planned. The design goal is simple, fast onset, strong effect, better tolerability, taken when needed.

Stigma makes serious problems look small. Data makes them obvious. And building turns obvious into inevitable. We’ve said for years that brain health is infrastructure; sexual health sits squarely inside that. That’s why we partnered with Kadence on a problem most investors label “awkward.” Awkward doesn’t scare us.

https://t.co/edJkCxq2Y6

[Kadence Bio @KadenceBio]

Talking about sexual health shouldn’t be taboo. At Kadence Bio, we’re working to empower men and couples to bridge the intimacy gap.
Our CEO John Boghossian breaks it down on The Meaning of Men podcast.
🎧 Listen: https://t.co/jFKRNSTnFA
#MensMentalHealth #IntimacyGap

[Kadence Bio @KadenceBio]

Kadence Bio is delighted to welcome @AmyPearlman1 to our Scientific Advisory Board. Dr. Pearlman is a board-certified urologist specializing in sexual health, hormone optimization, and genital reconstruction.

[Kadence Bio @KadenceBio]

Our Premature Ejaculation in the Media article explores how Sex and the City tackled PE, spotlighting both the humor and the stigma. We also highlight @RenaMalikMD's YouTube breakdown, where she debunks myths and shares real solutions. 💬✨
🔗 Read more: https://t.co/5RjxA5iWji

[Kadence Bio @KadenceBio]

Excited to share that Kadence Bio was recently featured in an interview by the Science Entrepreneur Club, a UK network of founders, investors, and academics in the biosciences. Thank you @science_eclub! https://t.co/g0fZGlvVP7

[Kadence Bio @KadenceBio]

Kadence Bio has been selected for the Grow London Global (@growldnbusiness) program, which aims to help startups reach their global expansion goals. To kick it off, our President will be heading to Japan next week on a trade mission to explore new opportunities and partnerships.

[Kadence Bio @KadenceBio]

Human enhancement is a growing trend, spanning physical, cognitive, and emotional improvements. Pharmaceutical drugs are often more widely used for lifestyle than clinical applications. Discover why this enhancement trend matters and our role in it... https://t.co/afMkkRAlAh

[Kadence Bio @KadenceBio]

Kanna Health is now Kadence Bio! Our new name better reflects our mission to improve sexual and mental wellbeing. KH-001 is in Phase 1 trials for premature ejaculation, and we're committed to advancing science for millions. Learn more about our journey at https://t.co/6Lay51MDLj.