Karreth Lab

The Karreth Lab: non-mutational drivers, melanoma progression, mouse models at the Moffitt Cancer Center. Account maintained by Florian. Tweets are his views.

[Karreth Lab @KarrethLab]

@bradylabupenn @ASBMB Congratulations Donita!! 🥳👏

[Melanoma Research Foundation @CureMelanoma]

A special thanks to Board Chair, Doug Brodman and his wife, Terry, for hosting their fifth fundraiser in Naples, Florida. Since its inception, this event has raised more than $300,000 to support young melanoma investigators—fueling breakthroughs from the discovery of a promising immune cell linked to improved patient outcomes to the development of a clinical trial enhancing TIL therapy for advanced melanoma.

Florian Karreth, PhD (@KarrethLab), MRF research grant recipient and researcher from @MoffittNews shared updates on the impact of basic science research and the profound impact that early funding of innovative science has on long term outcomes for melanoma patients.

[Karreth Lab @KarrethLab]

We also detected disseminated UM cells in the liver, making this a great model to study UM dormancy and metastasis

[Karreth Lab @KarrethLab]

Very excited that our new mouse model of #uveal #melanoma is now published at @CR_AACR. This model recapitulates the genetics and biology of human UM progression and will be a powerful tool for preclinical UM research.

[Cancer Research @CR_AACR]

Now online: A Multi-Step Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma https://t.co/VRcLKxRoHk

[Karreth Lab @KarrethLab]

Using this model, we identified two main UM cell states, melanocytic and neural crest-like, that may be associated with growth vs metastasis.

[Inna Smalley 🇺🇦 @InnaSmalley]

🚨🚨🚨Only 3 days left to apply for this incredible opportunity and to be considered for a nomination for the highly prestigious USF Presidential Doctoral Fellowship. #graduateschool #cancerresearch #phd

[Karreth Lab @KarrethLab]

Lead by Xiaonan Xu, our paper describing Fra1 as a driver of #melanoma #metastasis is now published in Oncogene
https://t.co/0JGaTQebzt

[Karreth Lab @KarrethLab]

Join our PhD program at Moffitt Cancer Center. We provide a world-class education in cancer biology, offer exquisite research infrastructure, and have fantastic labs and a wonderfully collaborative environment. And we are growing, i.e., offers will not be rescinded!

[Moffitt Cancer Center @MoffittNews]

Advance your career in #CancerResearch with the Moffitt Cancer PhD program! Application deadline: December 1, 2025

Are you passionate about fighting cancer? Our program prepares future scientists with a rigorous curriculum and offers four unique majors:
• Cancer Biology
• Cancer Chemical Biology
• Cancer Immunology & Immunotherapy
• Integrated Mathematical Oncology

Why Moffitt?
• Access to top research facilities
• Collaborate with world-leading scientists
• Hands-on experience in cutting-edge research
• Supportive environment for innovation
• Unmatched translational environment, turning discoveries into cures

Start your journey to make a difference in cancer care and innovation.

Learn more and apply now: https://t.co/qc33S8WvUe

[Peter Forsyth @PeterForsyth27]

Researchers at Moffitt Cancer Center have been awarded a $22.4 million grant from the U.S. Department of War to lead groundbreaking studies and clinical trials for leptomeningeal disease. @moffittnews @moffittresearch https://t.co/t0OTzN5l1x

[Karreth Lab @KarrethLab]

From the biology of melanocytes to pigmentation conditions and melanoma - we have it all! Join us in Tampa in March 2026 (great time to escape the cold) for the Annual Meeting of the @PASPCR1

[Karreth Lab @KarrethLab]

Interested in antisense #RNA and their contributions to #melanoma formation? Check out our latest paper: CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma: Cell Reports https://t.co/WLprdVH9SH

[Karreth Lab @KarrethLab]

This was fun to write and will be a useful resource for the melanoma field

[Gennie Parkman @GennieParkman]

Very proud to share our new review summarizing advances in understanding PTEN regulation and highlights its multifaceted role in suppressing melanomagenesis. Thank you to the best co-authors, @KarrethLab, @HolmenSheri, and Xiaonan Xu! https://t.co/FkUcocXE65

[Karreth Lab @KarrethLab]

Well deserved recognition for @NicolMecozzi who also was recently awarded a @theNCI F99 grant

[NicolMecozzi @NicolMecozzi]

Grateful for it, thank you! @CancerBiol_PhD @USouthFlorida @KarrethLab

[Karreth Lab @KarrethLab]

Wonderful news for the lab. Congrats @NicolMecozzi

[NicolMecozzi @NicolMecozzi]

Very happy and grateful for being awarded the F99/K00 award to continue studying circRNAs in melanoma metastasis 🥳
@KarrethLab @CancerBiol_PhD @theNCI @USouthFlorida

[Karreth Lab @KarrethLab]

Another preprint from our group, this one describing how the transcription factor FRA1 promoted #melanoma metastasis

[bioRxiv Cancer Bio @biorxiv_cancer]

FRA1 drives melanoma metastasis through an actionable transcriptional network https://t.co/10i73ML3CP #biorxiv_cancer

[Gomes Lab @lab_gomes]

Had a great time today touring the future Moffitt Discovery & Innovation Center! Excited for this new chapter for our Basic Science Division @MoffittNews lead by the amazing @LabElsaFlores

[Karreth Lab @KarrethLab]

@VitoRebecca1 thanks, Vito!

[Karreth Lab @KarrethLab]

Preprint alert: check out our new genetically engineered mouse model of uveal melanoma, which recapitulates many aspects of the human disease including phenotypic plasticity

[bioRxiv Cancer Bio @biorxiv_cancer]

A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanoma https://t.co/lJj509uW7T #biorxiv_cancer

[Moffitt Cancer Center @MoffittNews]

Live from #AACR25: Kaizhen Wang (@Kaizhen20) from the @KarrethLab discusses how MYBL2 drives melanoma through a surprising mechanism, non-canonical RNA binding. This newly uncovered function reveals how MYBL2 reshapes gene regulation and promotes tumor growth, offering fresh insight into melanoma progression.

Key insights:

•MYBL2 is pregulated and plays an oncogenic role in melanoma while represents a melanoma vulnerability

• MYBL2 binds RNA in melanoma but not in melanocytes, and it promotes melanoma growth through its RNA binding function.

• RNA binding of MYBL2 enhances its association with chromatin and drives a transcriptional program which associated with poor patient outcomes.

• Distinct melanoma RNA background is the main determinant to enable MYBL2 RNA binding in melanoma cells

Read more: https://t.co/AxabiQbkdd
#MoffittAACR25

[Moffitt Cancer Center @MoffittNews]

While at #AACR25, Kaizhen Wang (@Kaizhen20) from the @KarrethLab shares new insights on melanoma progression, revealing how non-canonical RNA binding by the MYBL2 transcription factor plays a key role in driving the disease.

Read more: https://t.co/ioPT8POVrf
#MoffittAACR25