Karreth Lab

The Karreth Lab: non-mutational drivers, melanoma progression, mouse models at the Moffitt Cancer Center. Account maintained by Florian. Tweets are his views.

[Karreth Lab @KarrethLab]

Check out our latest uveal melanoma paper: Allele‐Specific GNAQ Q209 Mutations Reveal Context‐Dependent Oncogenic Programs in Uveal Melanoma - Pigment Cell & Melanoma Research - Wiley Online Library https://t.co/0v9clxTEwc

[Society For Melanoma Research @SocietyMelanoma]

Save the Date for the 2027 SMR Congress in Boston, MA – registration and abstract submissions open September 9, 2026!

Visit the Congress website here: https://t.co/RryhOeJ0DY

[Karreth Lab @KarrethLab]

Our #uveal #melanoma mouse model paper is now in print at Cancer Research @CR_AACR. We hope this will be a resource to propel research in the UM field forward. Also check out the companion zebrafish UM paper by Colin Kenny's lab in the same issue!

[Cancer Research @CR_AACR]

Read the article featured on the cover of the August 1 issue: ➡️ A Multistep Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma https://t.co/R1euhtpFyV @KarrethLab #OpenAccess

[Karreth Lab @KarrethLab]

Check out our lab's latest preprint on a circRNA that promotes melanoma metastasis through cytoskeletal remodeling. Led by PhD student @NicolMecozzi

circPMS1-mediated LIM protein scaffolding promotes cytoskeletal remodeling and melanoma metastasis https://t.co/AIBBsOQdk8

[richard white @whitefishlab]

A fantastic new #zebrafish model of uveal #melanoma from the lab of @TheKennyLab. This demonstrates the power of modeling rare but difficult to treat cancers, opening up new avenues to understand the biology and find new treatments. It has been really nice seeing this story evolve and congrats on this beautiful work: https://t.co/HZSaXjb2Mn

[Karreth Lab @KarrethLab]

@bradylabupenn @ASBMB Congratulations Donita!! 🥳👏

[Melanoma Research Foundation @CureMelanoma]

A special thanks to Board Chair, Doug Brodman and his wife, Terry, for hosting their fifth fundraiser in Naples, Florida. Since its inception, this event has raised more than $300,000 to support young melanoma investigators—fueling breakthroughs from the discovery of a promising immune cell linked to improved patient outcomes to the development of a clinical trial enhancing TIL therapy for advanced melanoma.

Florian Karreth, PhD (@KarrethLab), MRF research grant recipient and researcher from @MoffittNews shared updates on the impact of basic science research and the profound impact that early funding of innovative science has on long term outcomes for melanoma patients.

[Karreth Lab @KarrethLab]

We also detected disseminated UM cells in the liver, making this a great model to study UM dormancy and metastasis

[Karreth Lab @KarrethLab]

Very excited that our new mouse model of #uveal #melanoma is now published at @CR_AACR. This model recapitulates the genetics and biology of human UM progression and will be a powerful tool for preclinical UM research.

[Cancer Research @CR_AACR]

Now online: A Multi-Step Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma https://t.co/VRcLKxRoHk

[Karreth Lab @KarrethLab]

Using this model, we identified two main UM cell states, melanocytic and neural crest-like, that may be associated with growth vs metastasis.

[Inna Smalley 🇺🇦 @InnaSmalley]

🚨🚨🚨Only 3 days left to apply for this incredible opportunity and to be considered for a nomination for the highly prestigious USF Presidential Doctoral Fellowship. #graduateschool #cancerresearch #phd

[Karreth Lab @KarrethLab]

Lead by Xiaonan Xu, our paper describing Fra1 as a driver of #melanoma #metastasis is now published in Oncogene
https://t.co/0JGaTQebzt

[Karreth Lab @KarrethLab]

Join our PhD program at Moffitt Cancer Center. We provide a world-class education in cancer biology, offer exquisite research infrastructure, and have fantastic labs and a wonderfully collaborative environment. And we are growing, i.e., offers will not be rescinded!

[Moffitt Cancer Center @MoffittNews]

Advance your career in #CancerResearch with the Moffitt Cancer PhD program! Application deadline: December 1, 2025

Are you passionate about fighting cancer? Our program prepares future scientists with a rigorous curriculum and offers four unique majors:
• Cancer Biology
• Cancer Chemical Biology
• Cancer Immunology & Immunotherapy
• Integrated Mathematical Oncology

Why Moffitt?
• Access to top research facilities
• Collaborate with world-leading scientists
• Hands-on experience in cutting-edge research
• Supportive environment for innovation
• Unmatched translational environment, turning discoveries into cures

Start your journey to make a difference in cancer care and innovation.

Learn more and apply now: https://t.co/qc33S8WvUe

[Peter Forsyth @PeterForsyth27]

Researchers at Moffitt Cancer Center have been awarded a $22.4 million grant from the U.S. Department of War to lead groundbreaking studies and clinical trials for leptomeningeal disease. @moffittnews @moffittresearch https://t.co/t0OTzN5l1x

[Karreth Lab @KarrethLab]

From the biology of melanocytes to pigmentation conditions and melanoma - we have it all! Join us in Tampa in March 2026 (great time to escape the cold) for the Annual Meeting of the @PASPCR1

[Karreth Lab @KarrethLab]

Interested in antisense #RNA and their contributions to #melanoma formation? Check out our latest paper: CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma: Cell Reports https://t.co/WLprdVH9SH

[Karreth Lab @KarrethLab]

This was fun to write and will be a useful resource for the melanoma field

[Gennie Parkman @GennieParkman]

Very proud to share our new review summarizing advances in understanding PTEN regulation and highlights its multifaceted role in suppressing melanomagenesis. Thank you to the best co-authors, @KarrethLab, @HolmenSheri, and Xiaonan Xu! https://t.co/FkUcocXE65

[Karreth Lab @KarrethLab]

Well deserved recognition for @NicolMecozzi who also was recently awarded a @theNCI F99 grant

[NicolMecozzi @NicolMecozzi]

Grateful for it, thank you! @CancerBiol_PhD @USouthFlorida @KarrethLab

[Karreth Lab @KarrethLab]

Wonderful news for the lab. Congrats @NicolMecozzi

[NicolMecozzi @NicolMecozzi]

Very happy and grateful for being awarded the F99/K00 award to continue studying circRNAs in melanoma metastasis 🥳
@KarrethLab @CancerBiol_PhD @theNCI @USouthFlorida

[Karreth Lab @KarrethLab]

Another preprint from our group, this one describing how the transcription factor FRA1 promoted #melanoma metastasis

[bioRxiv Cancer Bio @biorxiv_cancer]

FRA1 drives melanoma metastasis through an actionable transcriptional network https://t.co/10i73ML3CP #biorxiv_cancer