Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages - Thygesen - European Journal of Immunology - Wiley Online Library https://t.co/yvuqobgORd
Delighted to contribute to this work with Kate Stacey, Sara Thygensen and co. Read this 👇for the tips and tricks (and unexpected issues) of labelling active caspase-1 within cells! #inflammasome#caspase#pyroptosis
Curious on how to label CASP1 within a living cell? Check out our recent work on active CASP1 labelling and the importance of GSDMD @IMBatUQ@UQ_SCMB thanks to Kate Stacey & Sara Thygesen for bringing us along on this cool project #CASPASES 🤩 https://t.co/dMxOx5kNbV
Ever wondered how NLRP12 can drive autoinflammation? 👀
In our latest work, we show that NLRP12 is an endogenous inhibitor of NLRP3 inflammasome formation, but disease-causing NLRP12 mutants lose this capacity 🤯
A terrific article on how to set up a productive lab, with a positive lab culture that encourages the growth and scientific independence of its members. A must-read for all current or aspiring PIs! https://t.co/ptotAPNoGe