Biomedical scientist working on inflammation, metabolism, microbiota, cardiovascular diseases and cancer, views are my own and do not represent my employer.
Great time to start tweeting. Happy to share our paper “Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma” finally published in Cancer Discovery @CD_AACR. 1/1 https://t.co/46imoHUWK9
A new @CSCancerCare study suggests targeting a newly identified immune checkpoint pathway could lead to a better understanding of hepatocellular carcinoma. @KatyaKoltsova https://t.co/LAKr9EAyN7
We thank all our multiple collaborators for help with our work (@SGrivennikov and many others), and Reviewers and Editors at Cancer Discovery, especially @ElizSMcKenna for handling the manuscript. (end of the thread). 1/7
We hope that this discovery of a novel IL-27-dependent mechanism controlling anti-cancer cytotoxic immune response will pave the road for new treatment options for HCC and look forward to further study mechanisms how IL-27R pathway operates in cancer 1/6