Keith O’Shaughnessy

PhD Candidate in Organic (Carb) Synthesis & Crystallography in @UCC • @SSPCentre & @Researchirel Funded • Thriving to be a Specialist in Carbohydrate Chemistry

[Baran Lab @BaranLabReads]

🚨RADICAL RETHINK: STEREORETENTIVE CROSS COUPLING UNLOCKED🚨 Today in @ChemRxiv (https://t.co/zGZFCsK7aK) the first method for stereoretentive radical cross-coupling is disclosed. No fancy ligands or redox needed—just a Ni-diazene twist. 120 years after Gomberg, a new chapter begins.

Quick summary:
Since Gomberg discovered free radicals over 120 years ago and Kochi pioneered radical cross-coupling in the 1970s, this field has surged with interest for linking C(sp3) fragments. Unlike traditional polar methods (e.g., Suzuki), radical cross-coupling excels with saturated systems, offering mild conditions and chemoselectivity to build complex molecules from common fragments. Until now, enantiospecific radical cross-coupling was deemed impossible due to rapid racemization, but today that changes with readily available sulfonylhydrazides and a simple Ni-catalyst. This stereoretentive approach, enabled by a unique Ni-diazene transition state and driven by loss of N2, skips chiral ligands and redox steps, opening new possibilities for synthesis.

[Keith O’Shaughnessy @Keith_OS_97]

*PLEASE REPOST*

I’m currently finishing my PhD thesis in Synthetic Carbohydrate Chemistry & X-ray Crystallography. I am experienced in silyl protection, regioselective synthesis & complex structural elucidation.

I am looking for a postdoctoral position in related areas

[Jessica Sacher, PhD @JessicaSacher]

👀 Searching pubmed from inside my google sheet… winning!

[Organic Discussions @orgdisc]

Big thank you to @dJon_es for his wonderful talk on ‘Complexity generating dimerisation reactions’. It was a wonderful way to conclude Organic Discussions for 2023/2024! Thank you to all our speakers from the last year! Hopefully we’ll see some new and familiar faces next year!

[Keith O’Shaughnessy @Keith_OS_97]

Really enjoyed presenting a broad overview on glycotherapeutics today to some academic staff and researchers at @UCC @UCCResearch @uccchemistry today

[Organic Discussions @orgdisc]

A huge thanks to all who joined us for Organic Discussions this morning!

Insightful talks from @Keith_OS_97 on “Carbohydrate Based Drugs – An Insight to Glycotherapeutics” and Muireann on “Artificial Intelligence and Chemistry”

Our next session will take place on 11/04/2024!

[Organic Discussions @orgdisc]

Big thank you to @EliLillyandCo and @RoseOMahony for hosting Organic Discussions this morning! The site tour and talks from various employees were fantastic and gave everyone a great insight into the company. All of the postgrads that attended extend their gratitude! 🧪👩‍🔬👨‍🔬

[Organic Discussions @orgdisc]

Very successful start to Organic Discussions!

Wonderful talks from Amy, Emily and Emma on “The life and work of Dorothy Hodgkin”, “Aldehydes and Ketones as Flavouring Agents” and “Myth Busters: Organic Discussions Edition”

Our next session will take place on 16/11/2023!

[PWO UCC @PWO_UCC]

PhD researchers and even post-docs showing up in solidarity in front of Cork City Hall today to protest for better PhD pay and conditions 🙌🏼 #PGRsDeserveBetter #ResearchIsWork @PWO_Ireland

[PWO Ireland @PWO_Ireland]

#PGRsDeserveBetter

[PWO Ireland @PWO_Ireland]

This time last year government announced a pitiful €500 increase to stipends as a cost of living measure. On budget day.

This year @SimonHarrisTD says we should wait til Thursday to find out what we might get. Clearly not enough of a priority to feature in #Budget2024 statement

[PWO Ireland @PWO_Ireland]

We are disgusted to have been overlooked in #Budget2024 despite assurances from @dfheris that IRC/SFI stipends would go up.

We are struggling. We are the backbone of Irish research & higher edu. We are undervalued by the state & our universities.

We are fighting back - join us

[Keith O’Shaughnessy @Keith_OS_97]

@mcglackengroup @MarkPower96 @EurJOC @dJon_es @Katrina92Mackey Congrats @MarkPower96 & @mcglackengroup excellent work!

[Organic Discussions @orgdisc]

We're delighted to have the series of Organic Discussions for this semester culminate in an excellent site tour of ThermoFisher, Cork. Thanks to @thermofisher for this great opportunity for our postgrads and thanks to everyone who came along for the day. 🧪👩‍🔬👨‍🔬

[Keith O’Shaughnessy @Keith_OS_97]

@sbcsgalway

I keep trying to submit an abstract for the colloquium, however, the past few days I keep getting an error and I’m worried as the deadline is tomorrow.

See image below.

Thanks

[Keith O’Shaughnessy @Keith_OS_97]

I wish you could thumbs up an email.

Like I’m constantly torn between feeling rude for not replying or just sending a simple ‘thanks’ - which I feel is a waste of everybody’s time…

Just me?

[McGlacken Group @mcglackengroup]

This ⬇️ needed to be done, and now. Thank you to @SimonHarrisTD for initiating this. Hopefully it progresses with pace.
https://t.co/ZWTIr4sIcW

[Broccoli @shockingkeith]

I just signed this petition to @SimonHarrisTD to implement a minimum stipend of €28k for all PhD researchers to match the stipends of new proposed PhD research positions. Will you join me? #FairPayForPhDResearchers https://t.co/vnPjne93xJ via @UpliftIRL

[Keith O’Shaughnessy @Keith_OS_97]

@MichealMartinTD

[Broccoli @shockingkeith]

CORK CITY COUNCIL IS A FUCKING JOKE! Do we really live in a country where people who reside in the city, who work, and pay all of their taxes, no matter how extortionate they may be, are NOT entitled to a residential parking permit … BUT YET, are in-fact a resident of the city..

[Keith O’Shaughnessy @Keith_OS_97]

@ZGroupUL @CGD_ACS @Shasha__Jin @BernalNews @SSPCentre @ChemicalSciUL Congrats Shasha!

[Keith O’Shaughnessy @Keith_OS_97]

@hidear_3 Fierce, creative, confident