Kelly Chibale

Professor at @UCT_News; Neville Isdell Chair; Founder and Director of H3D research centre; Editor-In-Chief at ACS Medicinal Chemistry Letters.

[Kelly Chibale @Kelly_Chibale]

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#Afropessimism – a term that I often use to emphasize a critical & often ignored issue. It is sad that people don’t trust African scientific #innovation. I always say this & I repeat – as Africans, we must take pride in what is #locallyproduced & support #localproducers.

[BLANCO-MEDI @MJBlanco_medi]

Announcing Call for Papers for Special Issue on Allosteric Modulators in Drug Discovery. https://t.co/a2F7F25fFh

[ACS Publications Bio & Med Chem Content @ACSBioMed]

Don't forget to register for our upcoming webinar,
where winners of the 2026 Portoghese Lectureship Award will be discussing 'Emerging Medicinal Chemistry Approaches to Targeting Disease Pathways’.

📅 June 3, 12:00PM EDT

Register to attend: https://t.co/I35PhHMZEj

[ACS Publications Bio & Med Chem Content @ACSBioMed]

📢 Call for Abstracts: ACS150 JACS Symposium Series: University of Cape Town - Molecules to Medicine: Advancing Health Innovation in Africa!

📍 @UCT_news
📅 10-11 September

Submit your abstract before 10 June 2026. 

🔗 Apply today:  https://t.co/vLxqy7IkOq

[Kelly Chibale @Kelly_Chibale]

My latest essay reflects on how AI can strengthen African drug discovery and development ecosystems, from research and clinical trials to scientific capacity and locally relevant innovation.

https://t.co/Htiydp3xBN

#KellyChibale #AI #DrugDiscovery #AfricaScience #GlobalHealth

[Kelly Chibale @Kelly_Chibale]

It also reminded me that behind every medicine are years of research, collaboration, investment and volunteers who participate in clinical trials for the benefit of others.

[Kelly Chibale @Kelly_Chibale]

On #AfricaDay, I reflect on how surviving malaria as a child in Zambia shaped my life’s work in science and drug discovery.

Read more: https://t.co/5DmVlC1y3M

#KellyChibale #AfricaScience #GlobalHealth #MalariaResearch

[Kelly Chibale @Kelly_Chibale]

Scientists are designing smarter cancer drugs that target tumour cells while sparing healthy ones. A new class of molecules developed by Ipatova et al. showed activity against breast cancer cells with less harm to normal cells: https://t.co/W5slVG6PIl @ACSPublications

[Kelly Chibale @Kelly_Chibale]

Researchers have discovered a promising new way to treat pain without opioids. By targeting a specific “pain signal” channel (NaV1.8), Dialer et al. developed compounds that are more selective, longer-lasting and potentially safer: https://t.co/v4wzwguUBY @ACSPublications

[Kelly Chibale @Kelly_Chibale]

Scientists are getting a clearer picture of how diabetes and weight-loss drugs work. By watching receptors on cells in real time, they found that drugs “grab on” in two ways, helping to explain why some treatments work better than others: https://t.co/TGJrs4IskY @ACSPublications

[National Academy of Sciences @theNASciences]

Congratulations Kelly Chibale of @UCT_news, newly inducted NAS international member! #NAS163 #NASmember #chemistry #biology #pharmacology

[Kelly Chibale @Kelly_Chibale]

Identification of Natural-Product Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate Pathway https://t.co/mxHGtn7gUy @ACSPublications

#KellyChibale #AntibioticDiscovery #DrugDiscovery #MedicinalChemistry #AntimicrobialResistance #InfectiousDiseases #GlobalHealth

[Kelly Chibale @Kelly_Chibale]

Design, Synthesis, and Characterization of Prodrugs of Sulfonamide TLR4 Signaling Inhibitor TAK-242 (Resatorvid)

#DrugDevelopment #MedicinalChemistry #DrugDesign #ProdrugStrategy #InflammationResearch #Immunology #Resatorvid #Pharmacokinetics #DrugRelease #ChemicalBiology

[Kelly Chibale @Kelly_Chibale]

Discovery of a Colon-Targeted Prodrug as an Escherichia coli Biofilm Inhibitor for Treating Inflammatory Bowel Disease

https://t.co/JrE5pHf7x9 @ACSPublications

#MedicinalChemistry #DrugDiscovery #ProdrugDesign #IBDResearch #InflammatoryBowelDisease #MicrobiomeScience #Biofilms

[Kelly Chibale @Kelly_Chibale]

Isoindolines and Isoindoline-1,3-diones as Nonpeptide ACE Inhibitors: An In Silico and In Vitro Modeling Approach
https://t.co/cu58ylaWbC @ACSBioMed
#KellyChibale #MedicinalChemistry #Hypertension #CardiovascularResearch #ACEInhibitors #DrugDiscovery #ComputationalChemistry

[Kelly Chibale @Kelly_Chibale]

Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition–Associated Toxicity
https://t.co/ejIUH0mRCw @ACSBioMed
#KellyChibale #MedicinalChemistry #CancerResearch #MitochondrialBiology #OncologyResearch #DrugDiscovery

[Kelly Chibale @Kelly_Chibale]

Maltose-Conjugated Thiosemicarbazones from Substituted Benzaldehydes: Synthesis and Inhibitory Activity against Gram-(+) and Gram-(−) Bacteria
https://t.co/UFUG9xe9qx @ACSBioMed
#KellyChibale #AntimicrobialResistance #AntibioticDiscovery #InfectiousDiseases #DrugDiscovery

[Kelly Chibale @Kelly_Chibale]

Now an Honorary Fellow of the #RoyalSocietyofChemistry, its highest accolade. Encouraging to see recognition of science that combines excellence, leadership and societal impact. Read more: https://t.co/rEBJQoRKwL #KellyChibale #HonoraryFellow #ChemicalSciences #H3D #GlobalScience

[Schmidt Sciences @schmidtsciences]

Congratulations to Schmidt Sciences' AI2050 Senior Fellow @Kelly_Chibale on being named an Honorary Fellow of the @RoySocChem.

Dr. Chibale was one of seven world-renowned scientists recognized with the RSC's top accolade this year.
https://t.co/obsPlU9DQN

[Kelly Chibale @Kelly_Chibale]

Design, Synthesis, and Structure–Activity Relationship Studies of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as Potent Casein Kinase 1α (CK1α) Inhibitors @ACSBioMed
https://t.co/8V3qdJzwbz

#KellyChibale #CancerResearch #Leukaemia #TargetedTherapy #MedicinalChemistry #DrugDiscovery

[Kelly Chibale @Kelly_Chibale]

Characterization of the Formation of the Acyl Glucuronide Metabolite of 7-Carboxy-Cannabidiol in Human Liver, Kidney, and Intestinal Microsomes and In Vivo in Mice https://t.co/SL5wx5PvSE @ACSBioMed

#KellyChibale #DrugMetabolism #LiverToxicity #MedicinalChemistry #DrugSafety