Kelly Chibale

Professor at @UCT_News; Neville Isdell Chair; Founder and Director of H3D research centre; Editor-In-Chief at ACS Medicinal Chemistry Letters.

[Kelly Chibale @Kelly_Chibale]

1/2
#Afropessimism – a term that I often use to emphasize a critical & often ignored issue. It is sad that people don’t trust African scientific #innovation. I always say this & I repeat – as Africans, we must take pride in what is #locallyproduced & support #localproducers.

[Kelly Chibale @Kelly_Chibale]

2024 Top-Read Article in #ACSMedChemLett: Balanced Permeability Index: A Multiparameter Index for Improved In Vitro Permeability
Can one simple metric help guide permeability optimisation? https://t.co/sRCSaEUeX7 @ACSPublications #KellyChibale

[Kelly Chibale @Kelly_Chibale]

2024 Top-Read Article in #ACSMedChemLett: Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists
Exploring new serotonergic chemical space: https://t.co/oI4QYQfQHj @ACSPublications #KellyChibale

[Kelly Chibale @Kelly_Chibale]

2024 Top-Read Article in #ACSMedChemLett: Heteroaryl Glutarimides and Dihydrouracils as Cereblon Ligand Scaffolds for Molecular Glue Degrader Discovery
Expanding the molecular glue toolbox: https://t.co/LMayp6Xarq @ACSPublications #KellyChibale

[Kelly Chibale @Kelly_Chibale]

2024 Top-Read Article in #ACSMedChemLett: Chiral Switches of Tramadol Hydrochloride, a Potential Psychedelic Drug - Past and Future
https://t.co/YtzoTrxJkh @ACSBioMed

[ACS Publications Bio & Med Chem Content @ACSBioMed]

Our editors are catalysts for scientific progress as active researchers at top institutions. With expertise and global reach, they champion original research that shapes the future.

Join a community committed to advancing science and submit today: https://t.co/hxU1R1CniR

[ACS Publications Bio & Med Chem Content @ACSBioMed]

In the July Issue of #ACSMedChemLett Elena De Vita describes three must read articles.

https://t.co/ZeAxMI5Cot

[Kelly Chibale @Kelly_Chibale]

In #ACSMedChemLett, Kim et al. report a modified version of an existing drug (nitazoxanide) that shows promise against hepatitis B. 1 compound worked better than the original & showed good oral absorption, stability & efficacy in animal studies: https://t.co/5YXWhcZFbV @ACSBioMed

[Kelly Chibale @Kelly_Chibale]

Clofibric acid has been repurposed as a new “guiding tag” for a cutting-edge drug strategy that destroys harmful proteins, opening a new route for designing smarter cancer and disease treatments: https://t.co/RIz5LWzP0q #ACSMedChemLett @ACSBioMed

[ACS Publications Bio & Med Chem Content @ACSBioMed]

The June Issue of #ACSMedChemLett is out today! Sara Goldstein describes three must read articles this month In this Issue:

https://t.co/RWyEAQgPBb

[Kelly Chibale @Kelly_Chibale]

#ACSMedChemLett reports a greener, simpler way to make a new molecules that may fight bacteria. In early tests, bacteria did not develop resistance to one compound after many repeated exposures. @ACSBioMed https://t.co/O14AszyXLh

[ACS Publications Bio & Med Chem Content @ACSBioMed]

📢 Call for Abstracts: ACS150 JACS Symposium Series: University of Cape Town - Molecules to Medicine: Advancing Health Innovation in Africa!

📍 @UCT_news
📅 10-11 September

Submit your abstract before 10 June 2026. 

🔗 Apply today:  https://t.co/R3umonuh1L

[BLANCO-MEDI @MJBlanco_medi]

Announcing Call for Papers for Special Issue on Allosteric Modulators in Drug Discovery. https://t.co/a2F7F25fFh

[ACS Publications Bio & Med Chem Content @ACSBioMed]

Don't forget to register for our upcoming webinar,
where winners of the 2026 Portoghese Lectureship Award will be discussing 'Emerging Medicinal Chemistry Approaches to Targeting Disease Pathways’.

📅 June 3, 12:00PM EDT

Register to attend: https://t.co/I35PhHMZEj

[ACS Publications Bio & Med Chem Content @ACSBioMed]

📢 Call for Abstracts: ACS150 JACS Symposium Series: University of Cape Town - Molecules to Medicine: Advancing Health Innovation in Africa!

📍 @UCT_news
📅 10-11 September

Submit your abstract before 10 June 2026. 

🔗 Apply today:  https://t.co/vLxqy7IkOq

[Kelly Chibale @Kelly_Chibale]

My latest essay reflects on how AI can strengthen African drug discovery and development ecosystems, from research and clinical trials to scientific capacity and locally relevant innovation.

https://t.co/Htiydp3xBN

#KellyChibale #AI #DrugDiscovery #AfricaScience #GlobalHealth

[Kelly Chibale @Kelly_Chibale]

It also reminded me that behind every medicine are years of research, collaboration, investment and volunteers who participate in clinical trials for the benefit of others.

[Kelly Chibale @Kelly_Chibale]

On #AfricaDay, I reflect on how surviving malaria as a child in Zambia shaped my life’s work in science and drug discovery.

Read more: https://t.co/5DmVlC1y3M

#KellyChibale #AfricaScience #GlobalHealth #MalariaResearch

[Kelly Chibale @Kelly_Chibale]

Scientists are designing smarter cancer drugs that target tumour cells while sparing healthy ones. A new class of molecules developed by Ipatova et al. showed activity against breast cancer cells with less harm to normal cells: https://t.co/W5slVG6PIl @ACSPublications

[Kelly Chibale @Kelly_Chibale]

Researchers have discovered a promising new way to treat pain without opioids. By targeting a specific “pain signal” channel (NaV1.8), Dialer et al. developed compounds that are more selective, longer-lasting and potentially safer: https://t.co/v4wzwguUBY @ACSPublications

[Kelly Chibale @Kelly_Chibale]

Scientists are getting a clearer picture of how diabetes and weight-loss drugs work. By watching receptors on cells in real time, they found that drugs “grab on” in two ways, helping to explain why some treatments work better than others: https://t.co/TGJrs4IskY @ACSPublications