Excited to share our latest work published in @Nature, by grad student @mirazul302, currently on the job market. We uncovered clonal dynamics relating normal to tumor cells using natural and synthetic genetic changes. #SingleCell#DevBio#CRISPR#CRC#HTAN https://t.co/pxsT0HTgkT
Location, location, location—in Inflammatory bowel disease (#IBD)
https://t.co/3j8esSx7QY
Paige N. Spencer @Paige_N_Spencer, Monica E. Brown @moni_e_brown, Ken S. Lau @KenLauLab & team @VUMChealth determine how chronic inflammatory disease can manifest in a region-specific fashion, providing a unique model of #Crohn’s disease that reveals #Chlamydia and genetic risk as a trigging combination for Crohn’s disease-like inflammation in the proximal colon.
The image shows the host-pathobiont interface in the inflamed murine proximal colon, where intracellular Chlamydia muridarum (MOMP; green) in epithelial cells induces goblet cell-specific expression of indoleamine 2,3-dioxygenase 1 (IDO1; magenta); nuclei (blue). Image credit: Monica Brown, Paige Spencer, and William Kim.
Why does Crohn’s disease affect different regions of the GI tract? @Paige_N_Spencer tackled this in our latest study (in press @jclinicalinvest), uncovering region-specific responses that drive inflammation in the PROXIMAL colon to a pathobiont. 🔬🧬 https://t.co/ErShrL79On
Vanderbilt Symposium on AI, Spatial & Systems Biology 2025. Thank you all for coming out on the weekend! @VUBasicSciences. Key note: Dr. Jonathan Liu from Stanford on hybrid open top light sheet microscopy!
Excited to speak this weekend at the Vanderbilt Symposium on #AI, #Spatial & Systems Biology 2025—hosted by @KenLauLab and @tae_hwang at @VanderbiltU’s Center for Computational Systems Biology. 🌟A stellar speaker lineup!
Agenda: https://t.co/b7G8ayz1Vh Onsite full—join virtually
Congratulations to @K_Harsim from @KenLauLab for winning the Poster Prize at the Beatson International Cancer Conference 2025!
Thanks to @MolOncology for sponsoring this prize
#BICC2025
Thank you to @CRUK_SI and @DrPipDunne for a wonderful experience in Scotland for #BICC2025. Congratz to @K_Harsim for receiving the outstanding poster award!