Kerrin Small

Professor at King's College London

[Kerrin Small @kerrin_small]

Our paper on longitudinal multi-omics in an aging population is out at @ScienceMagazine

Led by @Julia_Moustafa , we profiled gene expression and metabolomics at 3 timepoints in 335 individuals over 6-8 years to investigate molecular aging trajectories
https://t.co/OuhxyCPCdm

[Kerrin Small @kerrin_small]

Very excited to share that our manuscript on cis-eQTL analysis of adipose tissue gene expression in 2,344 samples is now out in Nature Genetics
https://t.co/tTeAeBxivn

See thread from lead author @SarahBrotman below

[Sarah Brotman @SarahBrotman]

I’m excited to share that this manuscript is now published in Nature Genetics! 🧪🧬 🖥️

https://t.co/2uhGwcc57o

The AdipoExpress data can be accessed here: https://t.co/INRD9jcCsC

An interactive browser of the colocalization results can be accessed here: https://t.co/ODzXYlOjsF

[Inigo Martincorena @imartincorena]

Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n https://t.co/KBjrDfrxlj

[Matthew Neville @MDC_Neville]

Excited to share our new preprint in which we address:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/15]

https://t.co/gK0eGqXo4g

[Raheleh Rahbari @R_Rahbari]

II'm excited to finally share our study on the mutational landscape and selection dynamics in sperm, now live on medRxiv: https://t.co/S5VzzvOrA1. We explored how positive selection impacts mutation rates, especially with age. Here’s a quick thread on our findings! 🧵👇

[Alan Hodgkinson @alanjhodgkinson]

Several group leader positions available in Dept. of Medical and Molecular Genetics at King's College London (from lecturer to professor) - an exciting opportunity to join a thriving human genetics community and build something brilliant! https://t.co/bAf7O6v3Ea

[Sarah Brotman @SarahBrotman]

I am excited to share our preprint describing a collaborative effort to identify conditionally distinct signals in the largest adipose eQTL dataset to date (AdipoExpress)! @kerrin_small, @klmohlke, Laura Scott, @Julia_Moustafa, @mikelove, and others. 1/8

https://t.co/av0IuBR11p

[Kerrin Small @kerrin_small]

Our paper in collaboration with @MinaRyten and led by Karishma D’Sa
https://t.co/VG4knihmnf

[Nicole Rockweiler @nonfiniteloop]

Excited to share a local maximum of my grad school roller coaster ride: our paper “The origins and functional effects of postzygotic mutations throughout the human life span” is now published in @sciencemagazine: https://t.co/IfQYZMQ4tX. 1/4

[Kerrin Small @kerrin_small]

Our paper led by @anto_zito investigating variation in escape from X-inactivation across tissues, individuals and twin pairs is now published in @PlosGenetics https://t.co/LznvEzuSc3

Many thanks to @A_L_Roberts @_alesssia @Julia_Moustafa @MarioFalchi @TwinsUKres

[Kerrin Small @kerrin_small]

Our paper led by @A_L_Roberts on skewed X chromosome inactivation and its relationship with molecular and cellular measures of aging, cardiovascular disease risk, and cancer diagnoses is online at @elife
https://t.co/UFHU9DMZ7A

[School of Life Course & Population Health Sciences @lifecourse_KCL]

We're recruiting a Chair in Population Health Sciences & HoD of Population Health Sciences.

Population Health is a major new strategic priority for King’s & we're looking for an innovative & committed leader.

Deadline: 14 July 🗓️
Apply 👇

https://t.co/wQdI8Ym1cR

[Kerrin Small @kerrin_small]

Our paper investigating ACE2 gene expression in adipose tissue across three cohorts is now online at @IntJObesity

Work led by @Julia_Moustafa in collaboration with Anne Jackson, Li Guan, @SarahBrotman @klmohlke Laura Scott and others

https://t.co/kTRWaTPoEI

[Kerrin Small @kerrin_small]

@ceclindgren @girlscientist Thank you!!!

[Antonino Zito @anto_zito]

We conducted a transcriptomic survey to study properties of escape from X-inactivation across tissues and cells in female twins. @A_L_Roberts @_alesssia @Julia_Moustafa @MarioFalchi @kerrin_small @TwinsUKres
https://t.co/XRBLkSHgNy

[Prof Angelica Ronald @Gelironald]

**New!** London Genetics Network
- online launch meeting 4th Dec 2020
- early career poster prize
- great speaker line up
- all London human geneticists welcome
- forum to discuss network's remit
Register here: https://t.co/8ObBQajtXS PLEASE RT

[Jordana Bell @jordanatbell]

Recruiting for a 4-year BBSRC-funded PhD studentship in computational genomics of human skin ageing at @KingsCollegeLon in collaboration with Unilever; co-supervised by @kerrin_small and David Gunn.

UK/EU fees covered. Deadline 15 Oct 2020.

https://t.co/1BWwGPc5cV

[Kerrin Small @kerrin_small]

Heritability of adipose ACE2 expression levels was 30% in TwinsUK. Despite this heritability and our meta-analysis sample size, we did not identify cis- or trans-eQTLs for adipose ACE2 expression 4/4

[Kerrin Small @kerrin_small]

Our preprint “ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition”, with @Julia_Moustafa Anne Jackson, Li Guan @SarahBrotman @klmohlke Laura Scott @TwinsUKres 1/4

[medRxiv @medrxivpreprint]

ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition https://t.co/MT69kcESzF #medRxiv

[Kerrin Small @kerrin_small]

Adipose ACE2 expression was associated with the estimated cell type content of biopsies; positively correlated with proportion of microvascular endothelial cells (known to express ACE2 in other cardiovascular tissues) and negatively correlated with proportion of macrophages 3/4