@dr_demetre Thank you for your dedication and integrity. Your letter should alarm every Republican Congress member who has watched the unfolding disaster in meek, cowering silence. Does anyone in Washington care? So far the answer is no.
My resignation letter from CDC.
Dear Dr. Houry,
I am writing to formally resign from my position as Director of the National Center for Immunization and Respiratory Diseases at the Centers for Disease Control and Prevention (CDC), effective August 28, 2025, close of business.  I am happy to stay on for two weeks to provide transition, if requested.
This decision has not come easily, as I deeply value the work that the CDC does in safeguarding public health and am proud of my contributions to that critical mission. However, after much contemplation and reflection on recent developments and perspectives brought to light by Secretary Robert F. Kennedy Jr., I find that the views he and his staff have shared challenge my ability to continue in my current role at the agency and in the service of the health of the American people. Enough is enough.
While I hold immense respect for the institution and my colleagues, I believe that it is imperative to align my professional responsibilities to my system of ethics and my understanding of the science of infectious disease, immunology, and my promise to serve the American people.  This step is necessary to ensure that I can contribute effectively in a capacity that allows me to remain true to my principles.
I am unable to serve in an environment that treats CDC as a tool to generate policies and materials that do not reflect scientific reality and are designed to hurt rather than to improve the publicâs health.  The recent change in the adult and childrenâs immunization schedule threaten the lives of the youngest Americans and pregnant people.  The data analyses that supported this decision have never been shared with CDC despite my respectful requests to HHS and other leadership.  This lack of meaningful engagement was further compounded by a âfrequently asked questionsâ document written to support the Secretaryâs directive that was circulated by HHS without input from CDC subject matter experts and that cited studies that did not support the conclusions that were attributed to these authors.  Having worked in local and national public health for years, I have never experienced such radical non-transparency, nor have I seen such unskilled manipulation of data to achieve a political end rather than the good of the American people.
It is untenable to serve in an organization that is not afforded the opportunity to discuss decisions of scientific and public health importance released under the moniker of CDC.  The lack of communication by HHS and other CDC political leadership that culminates in social media posts announcing major policy changes without prior notice demonstrate a disregard of normal communication channels and common sense.  Having to retrofit analyses and policy actions to match inadequately thought-out announcements in poorly scripted videos or page long X posts should not be how organizations responsible for the health of people should function.  Some examples include the announcement of the change in the COVID-19 recommendations for children and pregnant people, the firing of scientists from ACIP by X post and an op-ed rather than direct communication with these valuable experts, the announcement of new ACIP members by X before onboarding and vetting have completed, and the release of term of reference for an ACIP workgroup that ignored all feedback from career staff at CDC.
The recent term of reference for the COVID vaccine work group created by this ACIP puts people of dubious intent and more dubious scientific rigor in charge of recommending vaccine policy to a director hamstrung and sidelined by an authoritarian leader.  Their desire to please a political base will result in death and disability of vulnerable children and adults.  Their base should be the people they serve not a political voting bloc.
I have always been first to challenge scientific and public health dogma in my career and was excited by the opportunity to do so again.  I was optimistic that there would be an opportunity to brief the Secretary about key topics such as measles, avian influenza, and the highly coordinated approach to the respiratory virus season.  Such briefings would allow exchange of ideas and a shared path to support the vision of âMaking America Healthy Again.â  We are seven months into the new administration, and no CDC subject matter expert from my Center has ever briefed the Secretary.  I am not sure who the Secretary is listening to, but it is quite certainly not to us.  Unvetted and conflicted outside organizations seem to be the sources HHS use over the gold standard science of CDC and other reputable sources.  At a hearing, Secretary Kennedy said that Americans should not take medical advice from him.  To the contrary, an appropriately briefed and inquisitive Secretary should be a source of health information for the people he serves. As it stands now, I must agree with him, that he should not be considered a source of accurate information.
The intentional eroding of trust in low-risk vaccines favoring natural infection and unproven remedies will bring us to a pre-vaccine era where only the strong will survive and many if not all will suffer.  I believe in nutrition and exercise.  I believe in making our food supply healthier, and I also believe in using vaccines to prevent death and disability.  Eugenics plays prominently in the rhetoric being generated and is derivative of a legacy that good medicine and science should continue to shun.
The recent shooting at CDC is not why I am resigning.  My grandfather, who I am named after, stood up to fascist forces in Greece and lost his life doing so.  I am resigning to make him and his legacy proud.   I am resigning because of the cowardice of a leader that cannot admit that HIS and his minionsâ words over decades created an environment where violence like this can occur.  I reject his and his colleaguesâ thoughts and prayers, and advise they direct those to people that they have not actively harmed.
For decades, I have been a trusted voice for the LGBTQ community when it comes to critical health topics.  I must also cite the recklessness of the administration in their efforts to erase transgender populations, cease critical domestic and international HIV programming, and terminate key research to support equity as part of my decision.
Public health is not merely about the health of the individual, but it is about the health of the community, the nation, the world. The nationâs health security is at risk and is in the hands of people focusing on ideological self-interest.
I want to express my heartfelt gratitude for the opportunities for growth, learning, and collaboration that I have been afforded during my time at the CDC. It has been a privilege to work alongside such dedicated professionals who are committed to improving the health and well-being of communities across the nation even when under attack from within both physically and psychologically.
Thank you once again for the support and guidance I have received from you and previous CDC leadership throughout my tenure. I wish the CDC continued success in its vital mission and that HHS reverse its dangerous course to dismantle public health as a practice and as an institution.  If they continue the current path, they risk our personal well-being and the security of the United States.
Sincerely,
Demetre C. Daskalakis MD MPH (he/his/him)
This is the big one: Kennedy is firing the entire #ACIP in a move he says is needed to restore confidence in vaccines.
"It scares me to think of whatâs ahead,â Mike Osterholm of CIDRAP told me. https://t.co/pgHkEM38LB
I havenât been on here in years but Iâll be in Boston next week for #SER2025 and want to know who else will be attendingâ anyone want to meet up for chat, coffee or lunch one day?
**Job Opportunity**
We are recruiting two teaching-focused Clinical Assistant Professors of epidemiology at @PHGSU. Reach out to me if you have any questions. Please RT.
https://t.co/lCBndHSMf6
@PHealthAngel@noelTbrewer Thanks so much for chiming in. It looks like we have overlapping interests (my K01 is also going to focus on intersectional stigma and discrimination, resilience and HIV outcomes). It would be great to connect at some point!
I'm submitting a K01 application to a mechanism which requires a Community Advisory Board as part of the project. Does anyone have experience with this? Should I describe the plan in the Research Strategy section? Somewhere else?
@A_Tweets_Stuff Python is great too, but itâs much less common in public health. I personally think itâs not going to catch on and momentum seems to be more toward R.
@A_Tweets_Stuff If you want to work in public health, R is the best language to pick up from free online courses. SAS is traditionally better (and what CDC uses and most schools teach) but a lot of CDC teams and schools are drifting to R so I think itâs the future.
Another year, another batch of MPH applications to review - and I'm still hating @SOPHASApp for asking recommenders to rate applicants on "intellectual ability" with letters of recommendation. I can't imagine this scale isn't influenced by racism, sexism and classism.
public health has an incredible capacity to write about death & illness without it being painful to read, or about resilience & community without it being joyous, celebratory, or at least making the reader smile.
if i could give public health students one piece of advice:
Whatâs something that scared you this week?
Iâll go first. My son went missing from his bedroom around 9:30 one night. We eventually found him in the backyard, completely unbothered by the dark, playing with the dog. Apparently he quietly crawled through the dog door to escape.
Given recent reports of mpox resurgence. We share this review highlighting special considerations when caring for people with HIV presenting with mpox https://t.co/zVVQi7fq2W @vcantosl @colleenfkelley@CarlosdelRio7 @DocWoc71 @Armstrws @JColasantiMD