KevinPomaski

Dad, Partner of @nicerinlynch Quantum, Triathlete, Unmanned solutions, Lidar and 3DReality. #FormerIntel #NJHC #Drones #Boats #Ironman #Marathonswimmer

[KevinPomaski @KevinPomaski]

Wanting to Believe in SS-31… But Human Trial Data Derails the Hype Train.. 🧵🍿

SS-31 (Elamipretide/Forzinity) is heavily hyped for mitochondrial support, energy, and healing. It now has FDA accelerated approval for one rare condition.
But what do the actual published human trials show on real dosing and efficacy?
Here’s the metadata breakdown (no hype, just the data).

1/7

[KevinPomaski @KevinPomaski]

@rorynotsorry @brentlajeunesse Come visit SW Florida!

[KevinPomaski @KevinPomaski]

@d0tslash Deserves the community’s attention!
All parents support you!!

#Righteous

[KevinPomaski @KevinPomaski]

I am 100% for all research and compounds that support healthy living! #LongPeptides
My goal is just honesty and transparency with information. Ai scrapes every post and there needs to be factual accuracy and not just cherry picking.

Can mastic gum supplementing antibiotic treatment be more effective, the data shows YES.
Solo, the data does not support that.

Also OP post is a sales pitch post.

Fact: Human (in vivo) evidence as monotherapy is weak or negative.

Bebb et al. (2003) : 9 patients with H. pylori infection, no ulcers). Participants took 1 g mastic gum four times daily for 14 days. No effect on H. pylori status by urea breath test (UBT) — all remained positive with no significant change in δ values.
OP cited Dabos et al. (2010):
30-38% eradication in N=52 after 5 weeks. That is significantly below antibiotic triple or quadruple protocols.

Stay researching and trying what may work. Just not with blinders and rose colored glasses.

“Correction: A 1999 correction (NEJM 1999;340:576) fixed a typo in the opening sentence — the referenced ulcer treatment dose was 1 g/day (not 1 mg/day)”

[Healthy Alfred 🌴🥥 @HealthyAlfred]

mastic gum ELIMINATED a stomach cancer trigger in 14 days.

I didn’t believe it either.

H. PYLORI.

38% complete eradication. mastic gum alone. 14 days. (19879118)

but that was just one bacteria.

→ P. gingivalis — 9/10 Alzheimer’s brains. killed. (16822220)

→ F. nucleatum — INSIDE colorectal tumors. killed. (Koychev 2017)

→ S. mutans — rotting your teeth. killed. (16343417)

→ Candida — brain fog, sugar cravings. killed. (8808717)

five pathogens. zero harm to good bacteria. no antibiotic can do that.

and it doesn’t just kill:

→ heartburn — 25/32 improved (19961914)

→ Crohn’s — 7/10 remission in 4 weeks (17278198)

a tree resin did what $7,000/month Humira does. for $1/day.

one island. Chios, Greece. 3,000 years. zero resistance. published in NEJM.

I take it EVERY day.

do what you want with this information.

🧵 where I get mine in the comments ↓

[KevinPomaski @KevinPomaski]

@ROIMindset Great job!!
Any plans for longer distances or focused on that sub 20’?

[Nichole Lynch, MSN, APRN, FNP-C @NicErinLynch]

@rorynotsorry You’re absolutely correct. This is why we need more providers to be educated in this area. I own a family practice, but I focus on women, peri/menopause. It’s complex but very needed, for bone, heart, brain and quality of life. Women need estradiol, progesterone AND testosterone

[KevinPomaski @KevinPomaski]

@I_Research_Pept 🛫 🇹🇷 👨🏼‍🦲👨🏼‍🦰🛬

[KevinPomaski @KevinPomaski]

@rorynotsorry @NicErinLynch I’m sure a lot of people could benefit from your sharing about how underserved the female population is and what providers like you are doing to change that!

[KevinPomaski @KevinPomaski]

@rorynotsorry LOL!!
“Cravings to eat like a bag of shit….
Shot time!! “ - Rory

[KevinPomaski @KevinPomaski]

I think we can both agree that “healthy” in this conversation is definitely not Barts kids and people that are doing well with panels and lifestyle. The issue there is that SS-31 targets aged, diseased or stressed mitochondria. Healthier person, way harder to “see” effectiveness.

I disagree with even the Anecdata statements. If you have objective data sets, please send over the link.
There are many ways to have full evaluations and prove efficacy, unfortunately, they are not available.
If you have actual muscle tissue biopsy, serum levels, PK and a few others.
I’d love to read them.

[KevinPomaski @KevinPomaski]

Wanting to Believe in SS-31… But Human Trial Data Derails the Hype Train.. 🧵🍿

SS-31 (Elamipretide/Forzinity) is heavily hyped for mitochondrial support, energy, and healing. It now has FDA accelerated approval for one rare condition.
But what do the actual published human trials show on real dosing and efficacy?
Here’s the metadata breakdown (no hype, just the data).

1/7

[KevinPomaski @KevinPomaski]

@peptidepirate just read you mention of SS-31.
Take a read at thread.

[KevinPomaski @KevinPomaski]

@RegenRandy I’d love to believe that “healthy” individuals would see benefit from any compound.
Reading data from trials, SS-31 would still require significant dosing for an impact on non-inflicted people.

[KevinPomaski @KevinPomaski]

Sources & Further Reading (all publicly available):
• FDA Accelerated Approval (Forzinity): https://t.co/TCabjXIPMZ
• FDA Label: https://t.co/U3PqnijIl1
• MMPOWER-3 (PMM Phase 3, failed primary endpoints): https://t.co/wCLDQGAnVT
• TAZPOWER / Barth Syndrome long-term data: Search https://t.co/DS7qe8luIz NCT03098797
• ReCLAIM-2 (AMD Phase 2): https://t.co/vETiKjm8WV
• Early dose-escalation & other trials: PubMed / https://t.co/DS7qe8luIz searches for “elamipretide”
7/7

[KevinPomaski @KevinPomaski]

Data > narrative. Always.

Full details and sources in the original research summary. Links in 7/7

What’s your take — still running based on mechanism, or does the trial record shift things for you?

#SS31 #Elamipretide #Peptides #ClinicalTrials #Mitochondria

6/7

[KevinPomaski @KevinPomaski]

The 40 mg Daily SC Standard (used in later trials + approval)
Most Phase 2/3 work standardized on 40 mg subcutaneous once daily.

For an 8-week example course:
• Total dose = 2,240 mg
• At typical trial concentration (~40 mg/mL) → 56 mL total volume (≈1 mL/day)

Scale to full Phase 3 lengths (12–24 weeks) and the commitment becomes substantial.

3/7

[KevinPomaski @KevinPomaski]

Early IV Dosing Conversions (from published Phase 1/2 trials)

These were the weight-based IV rates used in early human studies. Converted for real-world examples.

2/7

[KevinPomaski @KevinPomaski]

@KrisRChase Gender affirming care…
Cool.

[KevinPomaski @KevinPomaski]

@KrisRChase @999TeddyB Thanks for pointing this out.

The increase in RHR impacts for individuals is almost the same as for unfit ones.
We have seen, including ourselves, similar increase percentages.