Dennis Ritchie created C in the early 1970s without Google, Stack Overflow, GitHub, or any AI ( Claude, Cursor, Codex) assistant.
- No VC funding.
- No viral launch.
- No TED talk.
- Just two engineers at Bell Labs. A terminal. And a problem to solve.
He built a language that fit in kilobytes.
50 years later, it runs everything.
Linux kernel. Windows. macOS.
Every iPhone. Every Android.
NASA’s deep space probes.
The International Space Station.
> Python borrowed from it.
> Java borrowed from it.
> JavaScript borrowed from it.
If you have ever written a single line of code in any language, you did it in Dennis Ritchie’s shadow.
He died in 2011.
The same week as Steve Jobs.
Jobs got the front pages.
Ritchie got silence.
This Legend deserves to be celebrated.
Many drugs work by binding to a specific target in the body and blocking or changing what it does. An important first step in the drug development process is designing a molecule that can bind tightly to its target. Traditionally, that's meant weeks or months of expert work per target, sifting through a large number of candidates to identify the few that work.
We wanted to test if Claude could successfully design novel protein binders from scratch (also called de novo design). With a protein design prompt written by a human expert, Claude autonomously designed protein binders against 14 out of 15 targets.
We then worked with Adaptyv Bio and Twist Bioscience, who independently built and tested the proteins Claude designed.
Sí, el orden coincide con los pesos del algoritmo abierto de X: reportar (-234), silenciar (-58.8), no me interesa (-43.2) y bloquear (-31.2). Multiplican la probabilidad predicha de esa acción para cada usuario, no conteos crudos. Reportar además puede activar revisión de reglas.
I’m significantly older than you. I started coding in the late 60s. My current strategy is to not read any of the code written by my agents. That’s the only way I can take advantage of their productivity. What I do instead is to surround the agents with extreme constraints. Unit tests, gherkin tests, QA procedures, quality metrics, mutation testing, test coverage, and a plethora of others. In the end, I have very high confidence in the code they produce because they’ve had to run the gauntlet of all of my constraints and tests.
The 2026 FIFA World Cup is over! 🌍⚽
Over the course of the tournament, the Series Graph community rated every single match.
Here are the biggest takeaways from this year's World Cup. 👇
Quieren saber cuál es el problema de la clase científica mexicana?
Que un investigador top en México, entre estímulos y demás gana más de 10 veces la media mexicana, mientras que en otros países con trabajos llega a 4.
Mientras tanto esos investigadores nunca se retiran y no se abren nuevas plazas.
Google lanzó TabFM y ya empezaron los obituarios de XGBoost.
Curiosamente, muchos de los que declaran muerto al machine learning tradicional llevan años sin entrenar un modelo. Es fácil enterrar algo que nunca usaste.
Los hechos son menos dramáticos. TabFM es impresionante. En TabArena le gana a árboles de gradiente bien afinados. Eso es real y hay que reconocerlo.
Pero TabArena son 51 datasets. Tu dataset no es uno de ellos. Los promedios de benchmark esconden la varianza por dataset, y ningún modelo domina en todos los problemas.
Por eso sigue importando aprender los modelos básicos. Una regresión logística o un random forest bien hecho te da un baseline en minutos. Si no tienes ese baseline, no puedes saber si el cañón nuevo realmente te está dando algo, o solo te está cobrando en cómputo lo que un modelo simple hacía gratis.
Good example of strategy in life. 90% positioning, 10% explosive execution when the timing is right. Activity without achievement is a false god of the modern world.
🚩¿Vacaciones largas o varias vacaciones cortas?
Un estudio encontró que:
✅ El bienestar alcanza su pico en el día 8.
❌ Más días no aportan grandes beneficios adicionales.
📉 En menos de 7 días tras volver al trabajo, el efecto desaparece.
Por eso, hacer vacaciones más frecuentes podría ser una mejor estrategia para mantener el bienestar.
⚡ Microsoft now has a 2029 target for post-quantum cryptography.
The company says quantum advances have shifted the risk timeline.
Its roadmap brings PQC into SFI and focuses on TLS 1.3, crypto-agility, and trust chains for signing, certificates, keys, and updates.
Why Microsoft moved the timeline: https://t.co/3x81Fm2hVb