Kleger Lab

We are a team of scientists and physicians 🇩🇪🇦🇹🇫🇷🇮🇳🇺🇸 passionately working on #stemcells #organoids #cancer #pancreaticcancer @UniKlinikUlm. Est. 2009

[Kleger Lab @KlegerLab]

Visit the @Klegerlab under https://t.co/nzENsMZuwY and consider striving your career with us ! looking forward to receive your applications for PhD and/or postdoc !

[Kleger Lab @KlegerLab]

As #SarahMerz moves on to a postdoc with #DiegoBalboa at the #UniversityofHelsinki, we are excited to announce that we are recruiting the next generation of PhD students to join our successful team at #IMOS! 🌟 Let’s continue pushing the boundaries of diabetes research together!

[Kleger Lab @KlegerLab]

A special thanks to #MaureenGannon for summarizing both our studies in a fantastic preview article in #CellReports titled “CUTting through the distance - A disease-relevant long-range ONECUT1 enhancer.” https://t.co/liB8z9Q7aT Your support is invaluable!

[Kleger Lab @KlegerLab]

We also explored in vitro therapeutic options for affected patients and linked a low-frequency variant to type 2 diabetes. Excitingly, the #DanweiHuangfuLab utilized CRISPRi screening during pancreatic differentiation, confirming our findings regarding the same enhancer.Congrats!

[Kleger Lab @KlegerLab]

Here, we identified a disease-causing deletion upstream of OC1 in compound heterozygosity with an OC1 mutation in an affected individual, while investigating its functional role as a cis-acting enhancer influencing OC1 expression during pancreatic development.

[Kleger Lab @KlegerLab]

Building on this foundation, we're excited to announce our latest publication in #CellReports! Brilliant #SarahMerz completed her PhD with her second first authorship under the guidance of #SandraHeller, alongside #CecileJulier and me (https://t.co/D4M7ZP5YjU).

[Kleger Lab @KlegerLab]

We then discovered that OC1 coding mutations are associated with various forms of diabetes as modeled via pluripotent stem cell differentiation, details in #NatureMedicine (https://t.co/F17AtWVuJH).

[Kleger Lab @KlegerLab]

Our journey began with characterizing the regulatory patterns of ONECUT1 (OC1) during pancreatic lineage commitment, published in #CommunicationsBiology (https://t.co/F3cWVOUCiK).

[Kleger Lab @KlegerLab]

🚀 I am thrilled to add another piece to the “ONECUT1 diabetes” puzzle, again with joint forces between the #JulierLab at #INSERM and the collaborative efforts #IvanCosta, the Institutes of #HumanGenetics and #TransfusionMedicine at #UlmUniversity, and other collaborators!

[Kleger Lab @KlegerLab]

@gscn_office @uni_ulm Well deserved, great job Meike - group leader in the @klegerlab and vice-head of #IMOS !

[GSCN @gscn_office]

Freier Eintritt zur Podiumsdiskussion "Stammzellen - die Alleskönner" mit Wissenschaftler*innen zu Themen von Alterung bis Krebs. Wie ist der Stand der Forschung bei Zelltherapien? Am 15.9. in der vh Ulm. Info: https://t.co/S6HjQgttxJ @stadtulm @KlegerLab #stammzellen

[Kleger Lab @KlegerLab]

Our commenting summary just published in Cell Stem Cell https://t.co/H8oRcZ9hs1

[Kleger Lab @KlegerLab]

@CellStemCell It was a pleasure to comment on this important paper from the Wang lab. Cell Stem Cell https://t.co/aYtWpLJFdv

[Kleger Lab @KlegerLab]

Great work by the Wang lab: there is much heterogeneity in our beloved pancreas, congrats
Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis: Cell Stem Cell https://t.co/aYtWpLJFdv

[Kleger Lab @KlegerLab]

Congrats to work by the Wang lab, there is so much heterogeneity in our beloved pancreas!

Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis: Cell Stem Cell https://t.co/aYtWpLJFdv

[Kleger Lab @KlegerLab]

#klegerlab at https://t.co/nzENsMZuwY is hiring again...looking forward to get your applications

[Costa Lab - @costalab.bsky.social @vanvanka123]

@DKG_Berlin @UniklinikEssen @UniklinikUlm @chr_reinhardt @KlegerLab @KlegerLab Congrats Alex!

[Kleger Lab @KlegerLab]

Deeply honored to receive the prestigious https://t.co/K2fNg4e9Bh from @DKG_Berlin in the experimental category together with @chr_reinhardt for our work at https://t.co/nzENsN02mw Thanks to the entire @klegerlab @uni_ulm @UniklinikUlm and our friends and collaborators

[Kleger Lab @KlegerLab]

@r_gross_ Well deserved